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Registry of Toxic Effects of Chemical Substances (RTECS)

Diphenylamine

RTECS #

JJ7800000

CAS #

122-39-4

Updated

September 201

Molecular Weight

169.24

Molecular Formula

C12H11N

Synonyms

Aniline, N-phenyl-
Anilinobenzene
Benzenamine, N-phenyl- (9CI)
Benzene, (phenylamino)-
Benzene, anilino-
Big Dipper
C.I. 10355
Deccoscald 282
DFA
Difenylamin (Czech)
Diphenylamine (ACGIH:OSHA)
N,N-Diphenylamine
Naugalube 428L
N-Fenylanilin (Czech)
No-Scald
No-Scald DPA 283
N-Phenylaniline
N-Phenylbenzenamine
Scaldip
Shield DPA

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 7500 mg/kg (17-22D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemPEREBL 4,448,1970
oral/rat 12645 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)		HPV386 -,-,2001
unreported route/mammal (species unspecified) 131 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FEREAC 64,25845,1999
unreported route/mammal (species unspecified) 448 mg/kg (multigenerations)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)FEREAC 64,25845,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lethal dose (50 percent kill): 300 mg/kgHPV386 -,-,2001
oral/mammal (species unspecified) lethal dose (50 percent kill): 3200 mg/kgLung, Thorax, or Respiration: CyanosisGISAAA 40(10),114,1975
oral/mouse lethal dose (50 percent kill): 1230 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia		STGNBT -,104,1999
oral/mouse lethal dose (50 percent kill): 1750 mg/kgHPV386 -,-,2001
oral/rat lethal dose (50 percent kill): 1120 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia		STGNBT -,104,1999
oral/rat lethal dose (50 percent kill): 1165 mg/kgHPV386 -,-,2001
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgHPV386 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/gerbil lowest published toxic dose: 150 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV386 -,-,2001
intraperitoneal/hamster lowest published toxic dose: 1200 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes		HPV386 -,-,2001
intraperitoneal/hamster lowest published toxic dose: 2400 mg/kg/3D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen		HPV386 -,-,2001
intraperitoneal/hamster lowest published toxic dose: 1200 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)VTPHAK 27,171,1990
intraperitoneal/rat lowest published toxic dose: 1200 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV386 -,-,2001
oral/Dog lowest published toxic dose: 553680 mg/kg/96W- intermittentBlood: Normocytic anemia

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		HPV386 -,-,2001
oral/hamster lowest published toxic dose: 1200 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)HPV386 -,-,2001
oral/hamster lowest published toxic dose: 1800 mg/kg/3D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		HPV386 -,-,2001
oral/hamster lowest published toxic dose: 1200 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VTPHAK 27,171,1990
oral/mouse lowest published toxic dose: 1750 mg/kg/10D- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		STGNBT -,104,1999
oral/mouse lowest published toxic dose: 24080 mg/kg/80W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV386 -,-,2001
oral/mouse lowest published toxic dose: 80080 mg/kg/80W- intermittentBlood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV386 -,-,2001
oral/mouse lowest published toxic dose: 399840 mg/kg/80W- intermittentLiver: Other changes

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV386 -,-,2001
oral/mouse lowest published toxic dose: 2800 mg/kg/2D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV386 -,-,2001
oral/rat lowest published toxic dose: 25 mg/kg/30D- intermittentGastrointestinal: Alteration in gastric secretion

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria		STGNBT -,104,1999
oral/rat lowest published toxic dose: 309 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes		STGNBT -,104,1999
oral/rat lowest published toxic dose: 213120 mg/kg/640D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Interstitial nephritis		HPV386 -,-,2001
oral/rat lowest published toxic dose: 426880 mg/kg/640D- intermittentBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Interstitial nephritis		HPV386 -,-,2001
oral/rat lowest published toxic dose: 221711 mg/kg/19W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)HPV386 -,-,2001
oral/rat lowest published toxic dose: 20010 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen		HPV386 -,-,2001
oral/rat lowest published toxic dose: 4732 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Renal function tests depressed		HPV386 -,-,2001
oral/rat lowest published toxic dose: 1800 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Other changesHPV386 -,-,2001
oral/rat lowest published toxic dose: 2400 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Other changes		HPV386 -,-,2001
oral/rat lowest published toxic dose: 4662 mg/kg/14D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Changes in spleen weight		HPV386 -,-,2001
skin/rabbit lowest published toxic dose: 21000 mg/kg/21D- intermittentGastrointestinal: Other changesFEREAC 71,70703,2006
unreported route/rat lowest published toxic dose: 2082 mg/kg/3D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia		HPV386 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEVHPAZ 15,121,1976
TOXICOLOGY REVIEWCMSHAF 53,809,2003
TOXICOLOGY REVIEWFEREAC 71,70703,2006
TOXICOLOGY REVIEWHTOPA* 1,595,2002

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,177,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3DTLVS* 3,95,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.7 ppm (5 mg/m3);KZW 1.4 ppm (10 mg/m3), inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 5 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 4 mg/m3;short term exposure limit 12 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.7 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIPHENYLAMINE-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 27615; Number of Industries 97; Total Number of Facilities 10880; Number of Occupations 78; Total Number of Employees Exposed 155673; Total Number of Female Employees Exposed 20837
National Occupational Hazard Survey 1974Hazard Code 27615; Number of Industries 71; Total Number of Facilities 3217; Number of Occupations 55; Total Number of Employees Exposed 50967

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #78

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