Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethane, 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)-
RTECS #
KJ3675000CAS #
72-43-5Updated
December 2013Molecular Weight
345.66Molecular Formula
C16H15Cl3O2Synonyms
1,1'-(2,2,2-Trichloroethylidene)bis(4-methoxybenzene)1,1,1-Trichlor-2,2-bis(4-methoxy-phenyl)-aethan (German)
1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane
1,1,1-Trichloro-2,2-bis(p-anisyl)ethane
1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane
1,1,1-Trichloro-2,2-di(4-methoxyphenyl)ethane
1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane
2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane
2,2-Bis(4-methoxyphenyl)-1,1,1-trichloroethane
2,2-Bis(p-anisyl)-1,1,1-trichloroethane
2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane
2,2-Di-(p-methoxyphenyl)-1,1,1-trichloroethane
2,2-Di-p-anisyl-1,1,1-trichloroethane
4,4-(2,2,2-Trichloroethylidene)dianisole
Benzene, 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxy-
Di(p-methoxyphenyl)-trichloromethyl methane
Dianisyltrichlorethane
Dimethoxy-DDT
DMDT
ENT 1,716
Ethane, 2,2-bis(p-anisyl)-1,1,1-trichloro-
Higalmetox
Marlate
Methoxcide
Methoxychlor
Methoxychlor (ACGIH:OSHA)
Methoxychlor 2 EC
Methoxychlor technical
Methoxy-DDT
Metoksychlor (Polish)
Metox
Mezox K
Moxie
NCI-C00497
OMS 466
p,p'-Dimethoxydiphenyltrichloroethane
p,p'-Dwumetoksydwufenylotrojchloroetan (Polish)
p,p'-Methoxychlor
RCRA waste number U247
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | oral/mouse | 6 mg/kg/50D- intermittent | FOMOAJ 35,361,1976 |
| Cytogenetic Analysis | intraperitoneal/hamster | 50 mg/kg | ARTODN 58,152,1986 |
| DNA Damage | liver/rat | 150 µmol/L | EMMUEG 24,181,1994 |
| micronucleus test | subcutaneous/mouse | 49.5 mg/kg/3D- intermittent | REPTED 17,79,2003 |
| morphological transform | embryo/hamster | 10 mg/L | MUREAV 356,85,1996 |
| morphological transform | fibroblast/mouse | 2 mg/L | JJIND8 67,1303,1981 |
| mutation in microorganisms | lymphocyte/mouse | 10 mg/L (+enzymatic activation step) | EMMUEG 12(Suppl 13),103,1988 |
| sperm morphology | oral/rat | 28 gm/kg/10W-continuous | PSEBAA 176,187,1984 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | 800 mg/kg (1D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | REPTED 11,703,1997 |
| intraperitoneal/mouse | 320 mg/kg (20D prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes | TXAPA9 240,1,2009 |
| oral/rat | 280 mg/kg (7D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male | TOXID9 78,188,2004 |
| oral/rat | 1400 mg/kg (7D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive: Other effects on male | TOXID9 78,188,2004 |
| oral/rat | 216 mg/kg (15-22D preg/10D after birth) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects | ARTODN 78,232,2004 |
| oral/rat | 46.5 mg/kg (7D preg-77D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects | TOXID9 60,29,2001 |
| oral/rat | 1720 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Urogenital system | TOXID9 66,299,2002 |
| oral/mouse | 0.14 mg/kg (11-17D pregnant) | Reproductive: Other effects on female Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical | NETEEC 24,55,2002 |
| oral/rat | 2458 mg/kg (7-22D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOLED5 135,199,2002 |
| oral/rat | 3072 mg/kg (7-22D preg/4-7D after birth) | Reproductive: Specific developmental abnormalities: Endocrine system | TOLED5 135,199,2002 |
| oral/rat | 1760 mg/kg (1-22D preg/22D after birth) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects | TOSCF2 66,91,2002 |
| oral/rat | 1760 mg/kg (1-22D preg/22D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects | ETOPFR 18,161,2004 |
| oral/rat | 330 mg/kg (7-21D preg/51D after birth) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | TXCYAC 207,271,2005 |
| oral/mouse | 2000 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system | HBPTO* 1,733,2001 |
| oral/rat | 210 mg/kg (14-20D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | ENVRAL 18,437,1979 |
| oral/mouse | 140 µg/kg (11-17D pregnant) | Reproductive: Maternal effects: Postpartum Reproductive: Other effects on female Reproductive: Effects on newborn: Behavioral | NETEEC 24,55,2002 |
| oral/rat | 1720 mg/kg (1-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | TXCYAC 172,205,2002 |
| oral/rat | 216 mg/kg (15-21D preg/10D after birth) | Reproductive: Specific developmental abnormalities: Endocrine system | TOXID9 72,77,2003 |
| oral/rat | 1080 mg/kg (15-21D preg/10D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system | TOXID9 72,77,2003 |
| oral/rat | 1 gm/kg (11-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system | TOXID9 90,82,2006 |
| oral/rat | 1720 mg/kg (1-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 90,238,2006 |
| oral/rat | 50 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTPTR* NTR-MG96004 |
| oral/rat | 0.5 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | NTPTR* NTR-MG96004 |
| oral/rat | 0.055 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | NTPTR* NTR-MG96004 |
| oral/rat | 5 mg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Endocrine system | NTPTR* NTR-MG96004 |
| oral/mammal (species unspecified) | 100 mg/kg (1D preg-28D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical | NETEEC 28,103,2006 |
| oral/rat | 39 mg/kg (7D preg-64D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | TXCYAC 211,207,2005 |
| oral/rat | 216 mg/kg (15D preg-10D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic | TXAPA9 208,127,2005 |
| oral/rat | 40 mg/kg (multigeneration) | Reproductive: Effects on newborn: Physical | TOSCF2 91,93,2006 |
| oral/rat | 1.3 gm/kg (3W male/ 3W pre-3W after birth) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | JTPAE7 17,165,2004 |
| oral/rat | 638 mg/kg (3W male/ 3W pre-3W after birth) | Reproductive: Specific developmental abnormalities: Urogenital system | JTPAE7 18,89,2005 |
| oral/rat | 1.9 gm/kg (3W male/ 3W pre-3W after birth) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Homeostasis Reproductive: Other developmental abnormalities | JTPAE7 18,89,2005 |
| oral/rat | 6.4 gm/kg (3W male/ 3W pre-3W after birth) | Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system | JTPAE7 18,89,2005 |
| oral/rat | 6.4 gm/kg (3W male/ 3W pre-3W after birth) | Reproductive: Specific developmental abnormalities: Homeostasis Reproductive: Other developmental abnormalities | JTPAE7 18,89,2005 |
| oral/rat | 100 mg/kg (1D prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Other effects on female | TOXID9 -,234,2008 |
| oral/mouse | 640 mg/kg (20D prior to copulation) | Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 -,283,2008 |
| oral/rat | 340 µg/kg (5-21D pregnant) | Reproductive: Effects on newborn: Behavioral | NETEEC 31,203,2009 |
| oral/rat | 66 gm/kg (33D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | JPETAB 138,126,1962 |
| oral/rat | 2 gm/kg (6-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 45,435,1978 |
| oral/rat | 2 gm/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | TXAPA9 45,435,1978 |
| oral/rat | 4250 mg/kg (42D pre-21D after birth) | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Delayed effects | JAFCAU 22,969,1974 |
| oral/rat | 10625 mg/kg (42D pre-21D after birth) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | JAFCAU 22,969,1974 |
| oral/mouse | 1 gm/kg (20D pregnant) | Reproductive: Maternal effects: Ovaries, fallopian tubes | REPTED 5,139,1991 |
| oral/mouse | 900 mg/kg (6-8D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina | REPTED 6,431,1992 |
| oral/mouse | 2 gm/kg (6-15D pregnant) | Reproductive: Maternal effects: Parturition | REPTED 6,431,1992 |
| oral/mouse | 3 gm/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | REPTED 6,431,1992 |
| oral/rabbit | 330 mg/kg (6-27D pregnant) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Musculoskeletal system | CGANE7 39,190,1999 |
| oral/rat | 9800 mg/kg (multigeneration) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | TOXID9 15,164,1995 |
| oral/rat | 50400 mg/kg (multigeneration) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | TOXID9 15,164,1995 |
| oral/rat | 12600 mg/kg (multigeneration) | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | TOXID9 15,164,1995 |
| oral/rat | 1600 mg/kg (1-8D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | TXAPA9 97,454,1989 |
| oral/rat | 600 mg/kg (1-3D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TXAPA9 97,454,1989 |
| oral/rat | 1000 mg/kg (4-8D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | TXAPA9 97,454,1989 |
| oral/rat | 2150 mg/kg (0-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system | HBPTO* 2,1340,2001 |
| oral/rat | 18 gm/kg (14D prior to copulation/0-22D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | HBPTO* 2,1340,2001 |
| oral/rat | 2000 mg/kg (6-15D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | HBPTO* 2,1340,2001 |
| oral/rat | 400 mg/kg (1-2D pregnant) | Reproductive: Other effects to embryo or fetus | TXAPA9 102,110,1990 |
| oral/rat | 300 mg/kg (1-3D pregnant) | Reproductive: Other effects to embryo or fetus | TXAPA9 102,110,1990 |
| oral/rat | 10.8 gm/kg (43D male/43D pre-1D after birth) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | FAATDF 12,92,1989 |
| oral/rat | 11.2 gm/kg (43D male/43D pre-5D after birth) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | FAATDF 12,92,1989 |
| oral/rat | 12.6 gm/kg (6W prior to copulation) | Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Physical | JAFCAU 22,969,1974 |
| oral/rat | 23.8 gm/kg (73D pre-25D after birth) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | FAATDF 12,92,1989 |
| oral/rat | 5.4 gm/kg (43D male/43D pre-1D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FAATDF 12,92,1989 |
| oral/rat | 6.6 gm/kg (43D male/43D pre-25D after birth) | Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system | FAATDF 12,92,1989 |
| oral/rat | 6.6 gm/kg (43D male/43D pre-25D after birth) | Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Delayed effects | FAATDF 12,92,1989 |
| oral/rat | 4250 mg/kg (6W pre-21D after birth) | Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | JAFCAU 22,969,1974 |
| oral/rat | 50 mg/kg (multigenerations) | Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | JAFCAU 22,969,1974 |
| oral/rat | 7300 mg/kg (73D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | FAATDF 12,92,1989 |
| oral/rat | 8000 mg/kg (6W prior to copulation/22D pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) | JAFCAU 22,969,1974 |
| oral/rat | 8600 mg/kg (43D male/43D prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | FAATDF 12,92,1989 |
| oral/rat | 8750 mg/kg (5W prior to copulation) | Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) | JAFCAU 22,969,1974 |
| oral/rat | 9500 mg/kg (73D pre-1D after birth) | Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FAATDF 12,92,1989 |
| subcutaneous/mouse | 99 mg/kg (5-7D pregnant) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Behavioral | NETEEC 24,29,2002 |
| subcutaneous/mouse | 0.7 µg/kg (12-18D pregnant) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects | TXAPA9 183,10,2002 |
| subcutaneous/mouse | 99 mg/kg (5-7D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Behavioral | NETEEC 24,29,2002 |
| subcutaneous/mouse | 49.5 mg/kg (2-4D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | REPTED 17,79,2003 |
| subcutaneous/mouse | 99 mg/kg (2-4D pregnant) | Reproductive: Effects on fertility: Other measures of fertility | REPTED 17,79,2003 |
| subcutaneous/mouse | 99 mg/kg (5-7D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | REPTED 13,405,1999 |
| subcutaneous/mouse | 500.1 mg/kg (2-4D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Physical | REPTED 18,103,2004 |
| subcutaneous/mouse | 500.1 mg/kg (2-4D pregnant) | Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Physical | REPTED 18,103,2004 |
| subcutaneous/mouse | 500.1 mg/kg (2-4D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | REPTED 21,154,2006 |
| subcutaneous/domestic animal | 300 mg/kg (30-90D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Endocrine system | TXAPA9 247,98,2010 |
| unreported route/mouse | 64 mg/kg (1D prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 78,73,2004 |
| unreported route/mouse | 640 mg/kg (20D prior to copulation) | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 78,73,2004 |
| unreported route/rat | 2100 mg/kg (7D preg-7D after birth) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | HBPTO* 1,734,2001 |
| unreported route/rat | 50 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Physical | HBPTO* 1,734,2001 |
| unreported route/rat | 5800 mg/kg (15-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | HBPTO* 1,741,2001 |
| unreported route/rat | 1450 mg/kg (15-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | HBPTO* 1,741,2001 |
| unreported route/rat | 725 mg/kg (15-22D preg/21D after birth) | Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Physical | HBPTO* 1,741,2001 |
| unreported route/rat | 1600 mg/kg (1-8D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | HBPTO* 1,733,2001 |
| unreported route/mammal (species unspecified) | 1000 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | HBPTO* 1,733,2001 |
| unreported route/rat | 7 gm/kg (70D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | AHEMA5 9,89,1980 |
| unreported route/rat | 2100 mg/kg (21D prior to copulation) | Reproductive: Maternal effects: Oogenesis | AHEMA5 9,89,1980 |
| unreported route/rat | 9100 mg/kg (70D male/21D prior to copulation) | Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) | AHEMA5 9,89,1980 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/Dog | lowest published toxic dose: 383 gm/kg/3Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | EVHPAZ 36,205,1980 |
| oral/mouse | lowest published toxic dose: 56700 mg/kg/90W- continuous | Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Reproductive: Tumorigenic effects: Testicular tumors | JCROD7 93,173,1979 |
| oral/mouse | toxic dose: 62622 mg/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors | EVHPAZ 36,205,1980 |
| oral/mouse | lowest published toxic dose: 65.7 gm/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Testicular tumors | HBPTO* 2,1339,2001 |
| oral/rat | lowest published toxic dose: 73 gm/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria | HBPTO* 2,1339,2001 |
| oral/rat | toxic dose: 80 gm/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Reproductive: Tumorigenic effects: Ovarian tumors | LIFSAK 24,1367,1979 |
| oral/rat | toxic dose: 72800 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | EVHPAZ 36,205,1980 |
| oral/rat | toxic dose: 87360 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors | EVHPAZ 36,205,1980 |
| oral/rat | toxic dose: 10920 mg/kg/1Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease | AIPTAK 83,491,1950 |
| oral/rat | toxic dose: 45500 mg/kg/1Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease | AIPTAK 83,491,1950 |
| oral/rat | lowest published toxic dose: 18200 mg/kg/2Y- continuous | Tumorigenic: Carcinogenic by RTECS criteria Reproductive: Tumorigenic effects: Prostate tumors | EVHPAZ 36,205,1980 |
| oral/rat | toxic dose: 41 gm/kg/2Y- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Multiple effects Lung, Thorax, or Respiration: Other changes | TXAPA9 11,88,1967 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/hamster | lethal dose (50 percent kill): 500 mg/kg | ARTODN 58,152,1986 | |
| intraperitoneal/rat | lowest published toxic dose: 50 mg/kg | Endocrine: Estrogenic Related to Chronic Data: Changes in uterine weight | TXAPA9 14,358,1969 |
| oral/duck | lethal dose (50 percent kill): >2 gm/kg | PEMNDP 9,574,1991 | |
| oral/hamster | lethal dose (50 percent kill): 2000 mg/kg | HBPTO* 2,1337,2001 | |
| oral/human | lowest published lethal dose: 6430 mg/kg | PCOC** -,705,1966 | |
| oral/mouse | lethal dose (50 percent kill): 5000 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Urine volume increased | VCVGK* -,297,1994 |
| oral/mouse | lethal dose (50 percent kill): 510 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: Ataxia | GISAAA 58(1),44,1993 |
| oral/mouse | lethal dose (50 percent kill): 1850 mg/kg | HBPTO* 2,1337,2001 | |
| oral/rabbit | lethal dose (50 percent kill): >6 gm/kg | SPEADM 78-1,16,1978 | |
| oral/rat | lethal dose (50 percent kill): 5000 mg/kg | HBPTO* 2,1337,2001 | |
| oral/rat | lethal dose (50 percent kill): 5000 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Kidney, Ureter, and Bladder: Urine volume increased | VCVGK* -,297,1994 |
| oral/rat | lowest published toxic dose: 100 mg/kg | Endocrine: Other changes | TOXID9 -,234,2008 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Metabolism (intermediary): Other proteins | ARTODN 82,833,2008 |
| oral/rat | lethal dose (50 percent kill): 1855 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Behavioral: Ataxia | GISAAA 58(1),44,1993 |
| oral/rat | lowest published toxic dose: 4000 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | REPTED 6,491,1992 |
| skin/human | lowest published toxic dose: 2414 mg/kg | Behavioral: Somnolence (general depressed activity) | PCOC** -,705,1966 |
| skin/rabbit | lethal dose (50 percent kill): >6 gm/kg | WRPCA2 3,28,1964 | |
| skin/rat | lethal dose (50 percent kill): >6 gm/kg | CMEP** -,1,1956 | |
| subcutaneous/rat | lowest published toxic dose: 95 mg/kg | Endocrine: Estrogenic | JAFCAU 18,1108,1970 |
| unreported route/mammal (species unspecified) | lowest published toxic dose: 4000 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | HBPTO* 1,733,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lowest published toxic dose: 353 mg/kg/10D- intermittent | Related to Chronic Data: Changes in ovarian weight | BIREBV 42,573,1990 |
| intraperitoneal/mouse | lowest published toxic dose: 1777 mg/kg/10D- intermittent | Endocrine: Other changes | BIREBV 42,573,1990 |
| intraperitoneal/mouse | lowest published toxic dose: 178 mg/kg/10D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Uterus, cervix, vagina | BIREBV 42,573,1990 |
| intraperitoneal/mouse | lowest published toxic dose: 378 mg/kg/14D- intermittent | Endocrine: Effect on menstrual cycle Reproductive: Maternal effects: Ovaries, fallopian tubes Related to Chronic Data: Changes in ovarian weight | REPTED 9,379,1995 |
| intraperitoneal/mouse | lowest published toxic dose: 640 mg/kg/20D- intermittent | Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Ovaries, fallopian tubes | TOSCF2 68,473,2002 |
| intraperitoneal/mouse | lowest published toxic dose: 80 mg/kg/2W- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 60,383,2001 |
| intraperitoneal/mouse | lowest published toxic dose: 320 mg/kg/20D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TXAPA9 216,436,2006 |
| intraperitoneal/mouse | lowest published toxic dose: 320 mg/kg/20D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | NRTXDN 30,274,2009 |
| intraperitoneal/mouse | lowest published toxic dose: 1280 mg/kg/20D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NRTXDN 30,274,2009 |
| intraperitoneal/rat | lowest published toxic dose: 600 mg/kg/3D- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | TOLED5 144,93,2003 |
| intraperitoneal/rat | lowest published toxic dose: 1500 mg/kg/3D- intermittent | Liver: Changes in liver weight | TOLED5 144,93,2003 |
| intraperitoneal/rat | lowest published toxic dose: 600 mg/kg/3D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | TOLED5 144,93,2003 |
| oral/Dog | lowest published toxic dose: 365000 mg/kg/26W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,298,1994 |
| oral/Dog | lowest published toxic dose: 112000 mg/kg/8W- continuous | Eye: Other eye effects Behavioral: Tetany Kidney, Ureter, and Bladder: Other changes | VCVGK* -,298,1994 |
| oral/Dog | lowest published toxic dose: 168 gm/kg/24W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1338,2001 |
| oral/Dog | lowest published toxic dose: 84 gm/kg/6W- continuous | Behavioral: Convulsions or effect on seizure threshold | HBPTO* 2,1338,2001 |
| oral/Dog | lowest published toxic dose: 126 gm/kg/9W- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HBPTO* 2,1338,2001 |
| oral/mammal (species unspecified) | lowest published toxic dose: 7000 mg/kg/70D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | HBPTO* 1,733,2001 |
| oral/monkey | lowest published toxic dose: 4550 mg/kg/26W- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of operant conditioning | NETEEC 26,799,2004 |
| oral/monkey | lowest published toxic dose: 18250 mg/kg/1Y- intermittent | Behavioral: Alteration of operant conditioning Behavioral: Change in psychophysiological tests | NETEEC 24,87,2002 |
| oral/monkey | lowest published toxic dose: 18250 mg/kg/1Y- intermittent | Eye: Other eye effects Behavioral: Change in psychophysiological tests | NETEEC 24,87,2002 |
| oral/monkey | lowest published toxic dose: 6100 mg/kg/122D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 60,300,2001 |
| oral/mouse | lowest published toxic dose: 975 mg/kg/39D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | TOLED5 142,61,2003 |
| oral/mouse | lowest published toxic dose: 640 mg/kg/20D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | TOXID9 44,441,2005 |
| oral/mouse | lowest published toxic dose: 80 mg/kg/10D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 72,26,2003 |
| oral/mouse | lowest published toxic dose: 4000 mg/kg/4W- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | REPTED 6,93,1992 |
| oral/mouse | lowest published toxic dose: 2000 mg/kg/10D- intermittent | Reproductive: Maternal effects: Parturition | HBPTO* 1,733,2001 |
| oral/rabbit | lowest published toxic dose: 0.8 gm/kg/4D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Interstitial nephritis | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 5400 mg/kg/18D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Behavioral: Tremor | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 101.25 gm/kg/45D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HBPTO* 2,1337,2001 |
| oral/rat | lowest published toxic dose: 87.6 gm/kg/2Y- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1338,2001 |
| oral/rat | lowest published toxic dose: 76 gm/kg/760D- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male | HBPTO* 2,1340,2001 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/14D- continuous | Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Other effects on female | HBPTO* 2,1340,2001 |
| oral/rat | lowest published toxic dose: 500 mg/kg/10D- intermittent | Reproductive: Other effects on female Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HBPTO* 2,1340,2001 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/14D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Other proteins | JPETAB 294,308,2000 |
| oral/rat | lowest published toxic dose: 14 gm/kg/28D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Menstrual cycle changes or disorders Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 2.8 gm/kg/28D- intermittent | Reproductive: Maternal effects: Uterus, cervix, vagina Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 560 mg/kg/28D- intermittent | Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 14 gm/kg/28D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Lipids including transport | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 2.8 gm/kg/28D- intermittent | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 560 mg/kg/28D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 2.8 gm/kg/28D- intermittent | Liver: Other changes Endocrine: Adrenal cortex hyperplasia | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 14 gm/kg/28D- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | ARTODN 75,513,2001 |
| oral/rat | lowest published toxic dose: 700 mg/kg/14D- intermittent | Reproductive: Maternal effects: Uterus, cervix, vagina | TOSCF2 54,154,2000 |
| oral/rat | lowest published toxic dose: 1250 mg/kg/25D- intermittent | Reproductive: Maternal effects: Menstrual cycle changes or disorders | TOSCF2 54,154,2000 |
| oral/rat | lowest published toxic dose: 266 mg/kg/19W- intermittent | Liver: Other changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | GISAAA 53(10),82,1988 |
| oral/rat | lowest published toxic dose: 602 mg/kg/43W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 58(1),44,1993 |
| oral/rat | lowest published toxic dose: 20000 mg/kg/5D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | REPTED 6,491,1992 |
| oral/rat | lowest published toxic dose: 20000 mg/kg/4D- intermittent | Related to Chronic Data: Changes in prostate weight | REPTED 6,491,1992 |
| oral/rat | lowest published toxic dose: 800 mg/kg/8D- intermittent | Endocrine: Other changes | TXAPA9 97,454,1989 |
| oral/rat | lowest published toxic dose: 1600 mg/kg/8D- intermittent | Related to Chronic Data: Changes in uterine weight | TXAPA9 97,454,1989 |
| oral/rat | lowest published toxic dose: 1500 mg/kg/3D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 97,454,1989 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/5D- intermittent | Endocrine: Other changes | TXAPA9 97,454,1989 |
| oral/rat | lowest published toxic dose: 2500 mg/kg/5D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in uterine weight | TXAPA9 97,454,1989 |
| oral/rat | lowest published toxic dose: 600 gm/kg/10D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 30 gm/kg/10D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Behavioral: Food intake (animal) | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 13500 mg/kg/45D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 405 gm/kg/45D- continuous | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Liver: Changes in liver weight | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 405 gm/kg/45D- continuous | Related to Chronic Data: Changes in testicular weight | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 90 gm/kg/30D- continuous | Related to Chronic Data: Changes in testicular weight Behavioral: Food intake (animal) Reproductive: Paternal effects: Testes, epididymis, sperm duct | JPETAB 99,140,1950 |
| oral/rat | lowest published toxic dose: 21 gm/kg/7D- continuous | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TICEL* 13,369,1981 |
| oral/rat | lowest published toxic dose: 2000 mg/kg/10D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 72,132,2003 |
| oral/rat | lowest published toxic dose: 750 mg/kg/3D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TXAPA9 193,66,2003 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/7D- intermittent | Endocrine: Estrogenic Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Related to Chronic Data: Changes in testicular weight | TOXID9 44,112,2005 |
| oral/rat | lowest published toxic dose: 1075.2 mg/kg/7D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOLED5 135,199,2002 |
| oral/rat | lowest published toxic dose: 27960 mg/kg/60D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight | VCVGK* -,298,1994 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/6W- continuous | Related to Chronic Data: Changes in uterine weight Liver: Changes in liver weight Liver: Other changes | JAFCAU 22,969,1974 |
| oral/rat | lowest published toxic dose: 5250 mg/kg/6W- continuous | Related to Chronic Data: Changes in ovarian weight | JAFCAU 22,969,1974 |
| oral/rat | lowest published toxic dose: 8750 mg/kg/5W- continuous | Endocrine: Effect on menstrual cycle | JAFCAU 22,969,1974 |
| oral/rat | lowest published toxic dose: 4200 mg/kg/12W- continuous | Related to Chronic Data: Changes in ovarian weight Liver: Other changes | JAFCAU 22,969,1974 |
| oral/rat | lowest published toxic dose: 1600 mg/kg/8D- intermittent | Reproductive: Maternal effects: Uterus, cervix, vagina | TXAPA9 90,330,1987 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/56D- intermittent | Endocrine: Change in gonadotropins | TXAPA9 86,474,1986 |
| oral/rat | lowest published toxic dose: 2800 mg/kg/56D- intermittent | Endocrine: Other changes | TXAPA9 86,474,1986 |
| oral/rat | lowest published toxic dose: 1225 mg/kg/7W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/6W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 3500 mg/kg/5W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 700 mg/kg/1W- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 125 mg/kg/5D- intermittent | Endocrine: Effect on menstrual cycle Reproductive: Maternal effects: Uterus, cervix, vagina | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 200 mg/kg/4D- intermittent | Endocrine: Effect on menstrual cycle Reproductive: Maternal effects: Uterus, cervix, vagina | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 600 mg/kg/3D- intermittent | Endocrine: Effect on menstrual cycle Reproductive: Maternal effects: Uterus, cervix, vagina | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 6900 mg/kg/69D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 11900 mg/kg/119D- intermittent | Endocrine: Changes in pituitary weight Endocrine: Changes in adrenal weight Related to Chronic Data: Changes in ovarian weight | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 23800 mg/kg/119D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 2300 mg/kg/23D- intermittent | Reproductive: Other effects on male | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 3100 mg/kg/62D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 1550 mg/kg/62D- intermittent | Endocrine: Change in gonadotropins Endocrine: Other changes | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 5600 mg/kg/56D- intermittent | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 11200 mg/kg/56D- intermittent | Endocrine: Changes in pituitary weight Related to Chronic Data: Changes in testicular weight | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 7500 mg/kg/75D- intermittent | Endocrine: Androgenic Endocrine: Changes in pituitary weight Related to Chronic Data: Changes in testicular weight | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 15000 mg/kg/75D- intermittent | Blood: Other changes | FAATDF 12,92,1989 |
| oral/rat | lowest published toxic dose: 1720 mg/kg/42D- intermittent | Behavioral: Food intake (animal) | TXCYAC 172,205,2002 |
| oral/rat | lowest published toxic dose: 280 mg/kg/7D- intermittent | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | TOXID9 78,188,2004 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/7D- intermittent | Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other | TOXID9 78,188,2004 |
| oral/rat | lowest published toxic dose: 32.5 mg/kg/65D- continuous | Blood: Changes in spleen | TOXID9 60,29,2001 |
| oral/rat | lowest published toxic dose: 200 mg/kg/4D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport | ARTODN 76,692,2002 |
| oral/rat | lowest published toxic dose: 350 mg/kg/7D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in prostate weight | ARTODN 76,692,2002 |
| oral/rat | lowest published toxic dose: 69 mg/kg/3D- intermittent | Related to Chronic Data: Changes in uterine weight | TXAPA9 218,280,2007 |
| oral/rat | lowest published toxic dose: 250 mg/kg/20D- intermittent | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Maternal effects: Menstrual cycle changes or disorders | NTPTR* RACB-20103 |
| oral/rat | lowest published toxic dose: 1000 mg/kg/20D- intermittent | Liver: Changes in liver weight Endocrine: Changes in pituitary weight Related to Chronic Data: Changes in ovarian weight | NTPTR* RACB-20103 |
| oral/rat | lowest published toxic dose: 3600 mg/kg/72D- intermittent | Immunological Including Allergic: Increase in cellular immune response Immunological Including Allergic: Decrease in cellular immune response | NTPTR* MG96004 |
| oral/rat | lowest published toxic dose: 280 mg/kg/7D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | REPTED 21,148,2006 |
| oral/rat | lowest published toxic dose: 1400 mg/kg/7D- intermittent | Endocrine: Other changes Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | REPTED 21,148,2006 |
| subcutaneous/mouse | lowest published toxic dose: 500.1 mg/kg/3D- intermittent | Reproductive: Effects on fertility: Other measures of fertility | REPTED 18,103,2004 |
| subcutaneous/mouse | lowest published toxic dose: 150 mg/kg/3D- intermittent | Related to Chronic Data: Changes in uterine weight Endocrine: Estrogenic | EVHPAZ 104,1296,1996 |
| subcutaneous/rat | lowest published toxic dose: 750 mg/kg/30D- intermittent | Brain and Coverings: Recordings from specific areas of CNS | TXAPA9 197,319,2004 |
| subcutaneous/rat | lowest published toxic dose: 750 mg/kg/30D- intermittent | Endocrine: Change in LH Endocrine: Androgenic Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | FCTOD7 46,1570,2008 |
| unreported route/mammal (species unspecified) | lowest published toxic dose: 8000 mg/kg/4D- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | HBPTO* 1,733,2001 |
| unreported route/mouse | lowest published toxic dose: 640 mg/kg/20D- intermittent | Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | TOXID9 78,73,2004 |
| unreported route/mouse | lowest published toxic dose: 1280 mg/kg/20D- intermittent | Reproductive: Maternal effects: Ovaries, fallopian tubes | TOXID9 90,80,2006 |
| unreported route/mouse | lowest published toxic dose: 80 mg/kg/10D- intermittent | Reproductive: Maternal effects: Oogenesis Reproductive: Maternal effects: Uterus, cervix, vagina | TOXID9 66,377,2002 |
| unreported route/mouse | lowest published toxic dose: 320 mg/kg/10D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 66,377,2002 |
| unreported route/rat | lowest published toxic dose: 60000 mg/kg/300D- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | HBPTO* 1,733,2001 |
| unreported route/rat | lowest published toxic dose: 1600 mg/kg/8D- continuous | Reproductive: Maternal effects: Uterus, cervix, vagina Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | HBPTO* 1,733,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 10 mg/m3 | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 20,259,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 20,259,1979 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | TOLED5 127,101,2002 | |
| TOXICOLOGY REVIEW | RREVAH 56,107,1975 | |
| TOXICOLOGY REVIEW | CTOXAO 13,231,1978 | |
| TOXICOLOGY REVIEW | REPTED 22,164,2006 | |
| TOXICOLOGY REVIEW | MUREAV 616,7,2007 | |
| TOXICOLOGY REVIEW | ENTOX* -,258,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,61,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | REPTED 23,337,2007 | |
| TOXICOLOGY REVIEW | REPTED 23,374,2007 | |
| TOXICOLOGY REVIEW | REPTED 23,297,2007 | |
| TOXICOLOGY REVIEW | REPTED 25,316,2007 | |
| TOXICOLOGY REVIEW | MUREAV 543,251,2003 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | FCTOD7 46,813,2008 | |
| TOXICOLOGY REVIEW | FESTAS 90,911,2008 | |
| TOXICOLOGY REVIEW | REPTED 31,337,2011 | |
| TOXICOLOGY REVIEW | NBREV* 23,1011,1999 | |
| TOXICOLOGY REVIEW | MUREAV 727,62,2011 | |
| TOXICOLOGY REVIEW | REPTED 31,363,2011 | |
| TOXICOLOGY REVIEW | MUREAV 726,91,2011 | |
| TOXICOLOGY REVIEW | REPTED 33,269,2012 | |
| TOXICOLOGY REVIEW | REPTED 38,1,2013 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,132,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 10 mg/m3 | DTLVS* 3,152,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 10 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 15 mg/m3, inhal, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 10 mg/m3, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 mg/m3, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 10 mg/m3, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 15 mg/m3, inhal, 2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 mg/m3, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 10 mg/m3, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 10 mg/m3, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 10 mg/m3, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 10 mg/m3, JUL2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 10 mg/m3, inhal, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 15 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 10 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 15 mg/m3, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 15 mg/m3 | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 15 mg/m3, total dust | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOXYCHLOR-air | Carcinogen (0.07 mg/m3 LOQ) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 46210; Number of Industries 2; Total Number of Facilities 504; Number of Occupations 2; Total Number of Employees Exposed 3417 | |
| National Occupational Hazard Survey 1974 | Hazard Code 46210; Number of Industries 2; Total Number of Facilities 248; Number of Occupations 2; Total Number of Employees Exposed 638 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100202/AS) | |
| EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9 | |
| EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; SHE-clonal assay | |
| EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo | |
| EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion | |
| EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis | |
| EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3 | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat | NCITR* NCI-TR-35,1978 |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division