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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-(dibutylamino)-

RTECS #

KK3850000

CAS #

102-81-8

Updated

September 201

Molecular Weight

173.34

Molecular Formula

C10H23NO

Synonyms

2-Dibutylaminoethanol
2-Di-n-butylaminoethanol
2-N-Dibutylaminoethanol
2-N-Dibutylaminoethanol (ACGIH)
beta-n-Dibutylaminoethyl alcohol
BU2AE
DBAE
N,N-Dibutylethanolamine
N,N-Dibutyl-N-(2-hydroxyethyl)amine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test severeUCDS** 11/29/1963
skin /rabbit 5 mg/24H severe85JCAE -,695,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 120 mg/kgCardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea		TXAPA9 8,344,1966
intraperitoneal/mouse lethal dose (50 percent kill): 52 mg/kgRCRVAB 38,975,1969
intraperitoneal/rat lethal dose (50 percent kill): 144 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 12,486,1968
oral/rat lethal dose (50 percent kill): 1070 mg/kgAMIHBC 10,61,1954
skin/rabbit lethal dose (50 percent kill): 1680 µL/kgAMIHBC 10,61,1954

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 70 ppm/6H/5D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		AIHAAP 30,46,1969
oral/rat lowest published toxic dose: 7 gm/kg/5W- continuousKidney, Ureter, and Bladder: Changes in bladder weightAIHAAP 30,46,1969

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (14 mg/m3) (skin)DTLVS* 3,74,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (14 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (3.5 mg/m3);KZW 1 ppm (7 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (3.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (3.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (3.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (14 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (3.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (14 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 ppm (3.5 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (14 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (14 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 ppm (3.5 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (14 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3.5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2-N-DIBUTYLAMINOETHANOL-air10H time-weighted average 2 ppm (Sk)NIOSH* DHHS #95-121,1995

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007

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