Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethanol, 2-ethoxy-, acetate
RTECS #
KK8225000CAS #
111-15-9Updated
September 201Molecular Weight
132.18Molecular Formula
C6H12O3Synonyms
2-Aethoxy-aethylacetat (German)2-Ethoxyethanol acetate
2-Ethoxyethanol, ester with acetic acid
2-Ethoxyethyl acetate
2-Ethoxyethyl acetate (ACGIH:OSHA)
2-Ethoxy-ethylacetaat (Dutch)
2-Ethoxyethylacetate
2-Ethoxyethyle, acetate de (French)
2-Ethoxyethylester kyseliny octove (Czech)
2-Etossietil-acetato (Italian)
Acetate de cellosolve (French)
Acetate de l'ether monoethylique de l'ethylene-glycol (French)
Acetate d'ethylglycol (French)
Acetato di cellosolve (Italian)
Acetic acid, 2-ethoxyethyl ester
Aethylenglykolaetheracetat (German)
beta-Ethoxyethyl acetate
Cellosolve acetate
Cellosolve acetate (OSHA)
Celosolvacetat (Czech)
CSAC
EGEEA
Ektasolve EE acetate solvent
Ethoxy acetate
Ethoxyethyl acetate
Ethyl cellosolve acetaat (Dutch)
Ethylene glycol ethyl ether acetate
Ethylene glycol monoethyl ether acetate
Ethylglycol acetate
Ethylglykolacetat (German)
Glycol ether EE acetate
Glycol monoethyl ether acetate
Octan etoksyetylu (Polish)
Oxytol acetate
Poly-Solv EE acetate
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 40 mg | moderate | UCDS** 1/13/1967 |
| skin /rabbit | 490 mg open irritation test | mild | UCDS** 1/13/1967 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rabbit | 200 ppm/6H (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Respiratory system Reproductive: Specific developmental abnormalities: Urogenital system | UCRR** 09OCT1984 |
| inhalation/rabbit | 200 ppm/6H (6-18D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | UCRR** 09OCT1984 |
| inhalation/rabbit | 100 ppm/6H (6-18D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | UCRR** 09OCT1984 |
| inhalation/rabbit | 100 ppm/6H (6-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system | EVHPAZ 57,33,1984 |
| inhalation/rabbit | 450 ppm/6H (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** OTS0544004 |
| inhalation/rat | 600 ppm/7H (7-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | EPASR* 8EHQ-0682-0450 |
| inhalation/rat | 200 ppm/6H (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Respiratory system | FAATDF 10,20,1988 |
| inhalation/rat | 300 ppm/6H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Urogenital system | UCRR** 09OCT1984 |
| inhalation/rat | 50 mg/kg/4H (1-19D pregnant) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FAVUAI 21,30,1989 |
| inhalation/rat | 50 ppm/6H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | UCRR** 09OCT1984 |
| oral/mouse | 25 gm/kg (25D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | SAIGBL 21,29,1979 |
| oral/mouse | 100 gm/kg (25D male) | Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | SAIGBL 21,29,1979 |
| oral/mouse | 0.93 gm/kg (multigenerations) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB86139565 |
| oral/mouse | 1.86 gm/kg (multigenerations) | Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) | NTIS** #PB86139565 |
| oral/mouse | 1.86 gm/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Hepatobiliary system | NTIS** #PB86139565 |
| oral/mouse | 441 gm/kg (21W prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | NTIS** #PB86139565 |
| oral/mouse | 65.1 gm/kg (7D male/7D prior to copulation/21D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NTIS** #PB86139565 |
| skin/rat | 70 gm/kg (7-16D pregnant) | Reproductive: Maternal effects: Uterus, cervix, vagina Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | EVHPAZ 57,69,1984 |
| skin/rat | 70 gm/kg (7-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | EVHPAZ 57,69,1984 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rabbit | lethal concentration (50 percent kill): >2000 ppm/4H | Kidney, Ureter, and Bladder: Hematuria | TXAPA9 51,117,1979 |
| inhalation/rat | lethal concentration (50 percent kill): 12100 mg/m3/8H | AIHAAP 20,364,1959 | |
| inhalation/rat | lethal concentration (50 percent kill): >1500 ppm/8H | IJTOFN 21,9,2002 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 1420 mg/kg | SCCUR* -,2,1961 | |
| oral/guinea pig | lethal dose (50 percent kill): 1910 mg/kg | Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/guinea pig | lethal dose (50 percent kill): 1910 mg/kg | Behavioral: General anesthetic | IJTOFN 21,9,2002 |
| oral/rabbit | lethal dose (50 percent kill): 1950 mg/kg | EPASR* 8EHQ-0682-0450 | |
| oral/rat | lethal dose (50 percent kill): 2700 mg/kg | GISAAA 53(10),78,1988 | |
| oral/rat | lethal dose (50 percent kill): 2900 mg/kg | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Kidney, Ureter, and Bladder: Hematuria | IJTOFN 21,9,2002 |
| skin/guinea pig | lethal dose (50 percent kill): >19460 mg/kg | EPASR* 8EHQ-0682-0450 | |
| skin/rabbit | lethal dose (50 percent kill): 10500 µL/kg | UCDS** 1/13/1967 | |
| subcutaneous/mouse | lowest published lethal dose: 5 gm/kg | JPETAB 42,355,1931 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 84 gm/kg/4W- continuous | Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB86139565 |
| oral/mouse | lowest published toxic dose: 441 gm/kg/21W- continuous | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** #PB86139565 |
| oral/rat | lowest published toxic dose: 7560 mg/kg/2W- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases | ARTODN 73,229,1999 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | IJTOFN 21,9,2002 | |
| TOXICOLOGY REVIEW | CRTXB2 30,307,2000 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 100 ppm (540 mg/m3) (skin) | DTLVS* 3,101,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 5 ppm (27 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (27 mg/m3);KZW 20 ppm (108 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (27 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (27 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 2 ppm (11 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (27 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 2 ppm (11 mg/m3), skin, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 27 mg/m3, short term exposure limit 108 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (27 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 5 ppm (27 mg/m3), skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (27 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 50 ppm (270 mg/m3);short term exposure limit 100 ppm (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 5 ppm (27 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (27 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (27 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 100 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 10 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 5 ppm (30 mg/m3);short term exposure limit 10 ppm (50 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (11 mg/m3), KZG-week 16 ppm (88 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 27 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 100 ppm (540 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 100 ppm (540 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 10 ppm (55 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 100 ppm (540 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 100 ppm (540 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 100 ppm (540 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 100 ppm (540 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGEEA-air | 10H time-weighted average 0.5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code M4063; Number of Industries 149; Total Number of Facilities 16901; Number of Occupations 103; Total Number of Employees Exposed 265104; Total Number of Female Employees Exposed 51020 | |
| National Occupational Hazard Survey 1974 | Hazard Code M4063; Number of Industries 228; Total Number of Facilities 38895; Number of Occupations 127; Total Number of Employees Exposed 321063 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division