Registry of Toxic Effects of Chemical Substances (RTECS)
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Ethanol, 2-chloro-
RTECS #
KK0875000CAS #
107-07-3Updated
September 201Molecular Weight
80.52Molecular Formula
C2H5ClOSynonyms
2-Chloorethanol (Dutch)2-Chloraethanol (German)
2-Chlorethanol (German)
2-Chloroethanol
2-Chloroethanol (OSHA)
2-Chloroethyl alcohol
2-Cloroetanolo (Italian)
2-Monochloroethanol
Aethylenechlorhydrin (German)
beta-Chloroethyl alcohol
Chloroethanol
Chloroethylowy alkohol (Polish)
delta-Chloroethanol
Ethyleen-chloorhydrine (Dutch)
Ethylene chlorhydrin
Ethylene chlorohydrin
Ethylene chlorohydrin (ACGIH:OSHA)
Ethylene glycol, chlorohydrin
Glicol monocloridrina (Italian)
Glycol chlorohydrin
Glycol monochlorohydrin
Glycolmonochloorhydrine (Dutch)
Glycomonochlorhydrin
Monochlorhydrine du glycol (French)
NCI-C50135
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 2 mg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 33 mg | moderate | TXAPA9 16,382,1970 |
| eye /rabbit | 9 mg/6H | moderate | BUYRAI 31,25,1977 |
| skin /rabbit | 200 mg/2H | mild | TXAPA9 16,382,1970 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | inhalation/rat | 1 mg/m3 | GISAAA 36(11),9,1971 |
| Cytogenetic Analysis | oral/mouse | 500 µg/kg | GISAAA 43(8),13,1978 |
| Cytogenetic Analysis | ovary/hamster | 980 mg/L | EMMUEG 14,165,1989 |
| DNA repair | /Escherichia coli | 10 µmol/plate | MUREAV 26,367,1974 |
| mutation in microorganisms | /Klebsiella pneumoniae | 15 mmol/L (-enzymatic activation step) | EXPEAM 25,85,1969 |
| mutation in microorganisms | /Aspergillus nidulans | 40 gm/L (-enzymatic activation step) | CBINA8 30,9,1980 |
| mutation in microorganisms | /Salmonella typhimurium | 20 µmol/plate (+enzymatic activation step) | MUREAV 26,367,1974 |
| mutation in microorganisms | /Salmonella typhimurium | 3333 µg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
| mutation in microorganisms | lymphocyte/mouse | 80 mg/L (+enzymatic activation step) | EMMUEG 12,85,1988 |
| other mutation test systems | /Escherichia coli | 2914 µmol/L | EMMUEG 19,98,1992 |
| other mutation test systems | oral/rat | 20 mg/L | JACTDZ 1(3),37,1982 |
| other mutation test systems | liver/rat | 12 gm/L | JACTDZ 1(3),37,1982 |
| other mutation test systems | inhalation/rat | 1 mg/m3 | GISAAA 36(11),9,1971 |
| sex chromosome loss and nondisjunction | /Aspergillus nidulans | 74500 µmol/L | MUREAV 138,33,1984 |
| sister chromatid exchange | ovary/hamster | 1200 mg/L | SCIEAS 236,933,1987 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intravenous/mouse | 180 mg/kg (8-10D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | NTIS** #PB85-172104/AS |
| intravenous/mouse | 360 mg/kg (4-6D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | NTIS** #PB85-172104/AS |
| intravenous/mouse | 360 mg/kg (8-10D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other effects to embryo or fetus | NTIS** #PB85-172104/AS |
| intravenous/mouse | 360 mg/kg (10-12D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | NTIS** #PB85-172104/AS |
| oral/mouse | 1100 mg/kg (6-16D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Hepatobiliary system | JPFCD2 17,381,1982 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin/mouse | lowest published toxic dose: 156000 mg/kg/104W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Tumors | NTIS** PB86-145513/AS |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, liver tumor | Inhibitor Concentration (50 percent kill): 122 mmol/L/24H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 3,189,1989 |
| In Vitro/Non-mammalian species, fibroblast | Inhibitor Concentration (50 percent kill): 3.06 mmol/L/24H | In Vitro Toxicity Studies: Cell counting | TIVIEQ 7,537,1993 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 870 mg/m3 | GTPZAB 15(2),54,1971 | |
| inhalation/guinea pig | lethal concentration (50 percent kill): 870 mg/m3 | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| inhalation/human | Lowest published lethal concentration: 1000 mg/m3 | Behavioral: Somnolence (general depressed activity) Cardiac: Other changes Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,183,1994 |
| inhalation/man | Lowest published lethal concentration: 305 ppm/2H | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 26,277,1944 |
| inhalation/mouse | lethal concentration (50 percent kill): 385 mg/m3 | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | HYSAAV 36(4-6),376,1971 |
| inhalation/mouse | lethal concentration (50 percent kill): 385 mg/m3 | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| inhalation/rat | lethal concentration (50 percent kill): 290 mg/m3 | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| inhalation/rat | lethal concentration (50 percent kill): 290 mg/m3 | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | HYSAAV 36(4-6),376,1971 |
| inhalation/rat | lowest published toxic concentration: 40 mg/m3/4H | Brain and Coverings: Other degenerative changes Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGK* -,183,1994 |
| inhalation/rat | lowest published toxic concentration: 100 mg/m3 | Reproductive: Paternal effects: Testes, epididymis, sperm duct | VCVGK* -,183,1994 |
| inhalation/rat | lowest published toxic concentration: 1 mg/m3 | Blood: Changes in bone marrow not included in above | VCVGK* -,183,1994 |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 110 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 85 mg/kg | JPMSAE 61,19,1972 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 97 mg/kg | JPMSAE 61,19,1972 | |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 80 mg/kg | JPMSAE 61,19,1972 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 95 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| intraperitoneal/rat | lowest published lethal dose: 58 mg/kg | Lung, Thorax, or Respiration: Respiratory depression | TOXID9 90,249,2006 |
| intravenous/rabbit | lowest published lethal dose: 100 mg/kg | Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease | BJIMAG 1,207,1944 |
| oral/child | lowest published lethal dose: 396 mg/kg | JTCTDW 39,587,2001 | |
| oral/guinea pig | lethal dose (50 percent kill): 75 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| oral/guinea pig | lethal dose (50 percent kill): 110 mg/kg | Behavioral: General anesthetic Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Other changes | JIHTAB 23,259,1941 |
| oral/man | lowest published lethal dose: 330 mg/kg | JTCTDW 39,587,2001 | |
| oral/man | lowest published toxic dose: 88 mg/kg | Cardiac: Change in rate Gastrointestinal: Nausea or vomiting Vascular: BP lowering not characterized in autonomic section | JTCTDW 39,587,2001 |
| oral/mouse | lethal dose (50 percent kill): 91 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| oral/mouse | lethal dose (50 percent kill): 81 mg/kg | JPMSAE 60,568,1971 | |
| oral/rabbit | lethal dose (50 percent kill): 100 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,183,1994 |
| oral/rat | lethal dose (50 percent kill): 71 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | HYSAAV 36(4-6),376,1971 |
| oral/rat | lethal dose (50 percent kill): 71 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| oral/woman | lowest published toxic dose: 99 mg/kg | Cardiac: Pulse rate decreased with fall in BP Gastrointestinal: Nausea or vomiting | JTCTDW 39,587,2001 |
| oral/woman | lowest published lethal dose: 800 mg/kg | JTCTDW 39,587,2001 | |
| oral/woman | lowest published toxic dose: 99 mg/kg | Cardiac: Change in rate Gastrointestinal: Nausea or vomiting Vascular: BP lowering not characterized in autonomic section | JTCTDW 39,587,2001 |
| skin/guinea pig | lethal dose (50 percent kill): 20 mg/kg | VCVGK* -,183,1994 | |
| skin/guinea pig | lowest published lethal dose: 70 mg/kg | JIHTAB 27,93,1945 | |
| skin/mammal (species unspecified) | lowest published lethal dose: 0.07 mg/kg | TPKVAL 2,41,1961 | |
| skin/mouse | lethal dose (50 percent kill): 18 mg/kg | 85GMAT -,66,1982 | |
| skin/rabbit | lethal dose (50 percent kill): 67 mg/kg | JPMSAE 61,19,1972 | |
| skin/rabbit | lethal dose (50 percent kill): 700 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,183,1994 |
| skin/rat | lethal dose (50 percent kill): 293 mg/kg | NTPTR* NTP-TR-275,1985 | |
| subcutaneous/frog | lowest published lethal dose: 250 mg/kg | BJIMAG 1,207,1944 | |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 75 mg/kg | GTPZAB 15(2),54,1971 | |
| subcutaneous/mouse | lethal dose (50 percent kill): 98 mg/kg | GTPZAB 15(2),54,1971 | |
| subcutaneous/rabbit | lethal dose (50 percent kill): 100 mg/kg | GTPZAB 15(2),54,1971 | |
| subcutaneous/rat | lethal dose (50 percent kill): 84 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea | HYSAAV 36(4-6),376,1971 |
| subcutaneous/rat | lethal dose (50 percent kill): 84 mg/kg | Brain and Coverings: Increased intracranial pressure Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) | VCVGK* -,182,1994 |
| unreported route/mouse | lethal dose (50 percent kill): 91 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | GISAAA 43(8),13,1978 |
| unreported route/rat | lethal dose (50 percent kill): 71 mg/kg | Brain and Coverings: Recordings from specific areas of CNS | GISAAA 43(8),13,1978 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 3400 mg/m3/15M/11D- intermittent | Liver: Fatty liver degeneration Blood: Hemorrhage Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BJIMAG 1,207,1944 |
| inhalation/rat | lowest published toxic concentration: 1 mg/m3/4H/17W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | GISAAA 36(6),37,1971 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/4H/28D- intermittent | Brain and Coverings: Other degenerative changes Blood: Change in clotting factors Blood: Changes in bone marrow not included in above | VCVGK* -,183,1994 |
| inhalation/rat | lowest published toxic concentration: 1 mg/m3/4H/28D- intermittent | Endocrine: Hypoglycemia Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | VCVGK* -,183,1994 |
| inhalation/rat | lowest published toxic concentration: 10 mg/m3/122D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,183,1994 |
| intraperitoneal/rat | lowest published toxic dose: 384 mg/kg/30D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPMSAE 60,1163,1971 |
| intraperitoneal/rat | lowest published toxic dose: 1152 mg/kg/12W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JPMSAE 60,1163,1971 |
| intravenous/mouse | lowest published toxic dose: 360 mg/kg/3D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB85-172104/AS |
| intravenous/rabbit | lowest published toxic dose: 81 mg/kg/9D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** #PB85-170959/AS |
| oral/Dog | lowest published toxic dose: 1932 mg/kg/15W- intermittent | Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FCTXAV 13,313,1975 |
| oral/rat | lowest published toxic dose: 5670 mg/kg/12W- intermittent | Liver: Changes in liver weight Endocrine: Changes in pituitary weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | FCTXAV 13,313,1975 |
| oral/rat | lowest published toxic dose: 91 mg/kg/26W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Endocrine: Other changes | VCVGK* -,183,1994 |
| oral/rat | lowest published toxic dose: 91 mg/kg/26W- intermittent | Gastrointestinal: Changes in structure or function of exocrine pancreas | GISAAA 41(7),102,1976 |
| skin/mouse | lowest published toxic dose: 1411 gm/kg/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-275,1985 |
| skin/mouse | lowest published toxic dose: 1154 mg/kg/13W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-275,1985 |
| skin/rat | lowest published toxic dose: 6188 mg/kg/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-275,1985 |
| skin/rat | lowest published toxic dose: 32500 mg/kg/13W- intermittent | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-275,1985 |
| unreported route/rat | lowest published toxic dose: 910 mg/kg/26W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | GISAAA 43(8),13,1978 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-ceiling concentration 1 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | CMTVAS 10(3),49,1973 | |
| TOXICOLOGY REVIEW | REPTED 25,192,2008 | |
| TOXICOLOGY REVIEW | MUREAV 727,42,2011 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (16 mg/m3) | DTLVS* 3,108,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 1 ppm (3.3 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (3 mg/m3);KZW 5 ppm (15 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | short term exposure limit 1 ppm (3.3 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 1 ppm (3 mg/m3), skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 1 ppm (3.3 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 1 ppm (3 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 1 ppm (3.3 mg/m3), 2011 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 1 ppm (3.5 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 1 ppm (3 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | peak 1 ppm (3 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 1 ppm (3.3 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-PERU | short term exposure limit 1 ppm (3.3 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.5 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | ceiling concentration 1 ppm (3.5 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 1 ppm (3 mg/m3), skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-C 3 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 ppm (16 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 ppm (16 mg/m3), JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | short term exposure limit 1 ppm (3.4 mg/m3), skin, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (16 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (16 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (16 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (16 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE CHLOROHYDRIN-air | ceiling concentration 1 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X4018; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 476; Total Number of Female Employees Exposed 68 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division