Registry of Toxic Effects of Chemical Substances (RTECS)
Ether, 2,2,2-trifluoroethyl vinyl
RTECS #
KO4250000CAS #
406-90-6Updated
April 2012Molecular Weight
126.09Molecular Formula
C4H5F3OSynonyms
2,2,2-Trifluoroethyl vinyl etherEthene, (2,2,2-trifluoroethoxy)-
Floroxene
Fluooxene
Fluoromar
Fluoroxene
Fluorxene
Fluroxene
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
mutation in microorganisms | /Salmonella typhimurium | 5 pph (-enzymatic activation step) | MUREAV 58,183,1978 |
mutation in microorganisms | /Escherichia coli | 5 pph (+enzymatic activation step) | MUREAV 58,183,1978 |
sex chromosome loss and nondisjunction | inhalation/Drosophila melanogaster | 2 pph/1H | ANESAV 62,305,1985 |
sister chromatid exchange | ovary/hamster | 24700 ppm | ANESAV 50,426,1979 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/monkey | 8 pph/20M (22W pregnant) | Reproductive: Other effects to embryo or fetus | AANEAB 20,183,1976 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/man | lowest published toxic concentration: 2 pph/90M | Liver: Jaundice, other or unclassified Liver: Liver function tests impaired | ANESAV 37,462,1972 |
inhalation/mouse | Lowest published lethal concentration: 4 pph/1H | BJANAD 48,399,1976 | |
intraperitoneal/rat | lethal dose (50 percent kill): 5600 mg/kg | TXAPA9 71,84,1983 |
Reviews
Organization | Standard | Reference |
---|---|---|
International Agency for Research on Cancer (IARC) | Cancer Review:Animal No Adequate Data | IMSUDL 7,93,1987 |
TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
TOXICOLOGY REVIEW | NBREV* 5,1,1981 |
Standards and Regulations
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUROXENE-air | ceiling concentration 2 ppm/60M | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code M5153; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 5 | |
National Occupational Hazard Survey 1974 | Hazard Code M5153; Number of Industries 1; Total Number of Facilities 112; Number of Occupations 3; Total Number of Employees Exposed 448 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay | |
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division