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Registry of Toxic Effects of Chemical Substances (RTECS)

Glycerol

RTECS #

MA8050000

CAS #

56-81-5

Updated

September 201

Molecular Weight

92.11

Molecular Formula

C3H8O3

Synonyms

1,2,3-Propanetriol
1,2,3-Trihydroxypropane
90 Technical glycerine
Citifluor AF 2
Clyzerin, wasserfrei (German)
Glycerin
Glycerin mist
Glycerin mist (ACGIH,OSHA)
Glycerin, anhydrous
Glycerin, synthetic
Glycerine
Glyceritol
Glycyl alcohol
Grocolene
MOON
Osmoglyn
Star
Synthetic glycerin
Trihydroxypropane

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,207,1986
skin /rabbit 500 mg/24H mild85JCAE -,207,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat1 gm/kgTGANAK 19,436,1985
DNA inhibitionlymphocyte/human200 mmol/LPNASA6 79,1171,1982

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 280 mg/kg (2D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		CCPTAY 29,291,1984
intratesticular/rat 1600 mg/kg (1D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)CCPTAY 29,291,1984
intratesticular/rat 862 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)LIFSAK 34,1747,1984
intratesticular/monkey 119 mg/kg (1D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct		CCPTAY 39,447,1989
oral/rat 100 mg/kg (1D male)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TGANAK 19,436,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 87.5 gm/kg/25W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Facilitates action of known carcinogens		CALEDQ 229,181,2005

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 983 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.035 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
intramuscular/rat lowest published toxic dose: 5 mL/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)FCTOD7 50,2622,2012
intramuscular/rat lowest published toxic dose: 5000 mg/kgKidney, Ureter, and Bladder: Renal function tests depressedEKFAE9 55,21,1992
intramuscular/rat lowest published toxic dose: 8 mL/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXCYAC 201,143,2004
intramuscular/rat lowest published lethal dose: 10 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition		NPRNAY 20,47,1978
intramuscular/rat lowest published toxic dose: 4 mL/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases		PHMCAA 67,41,2003
intramuscular/rat lowest published toxic dose: 4000 mg/kgKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		FCTOD7 46,710,2008
intramuscular/rat lowest published lethal dose: 10 mL/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		CEXPB9 33,119,2006
intramuscular/rat lowest published toxic dose: 4 mL/kgVascular: Contraction (isolated tissue)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes		JPETAB 322,461,2007
intraperitoneal/mouse lethal dose (50 percent kill): 8700 mg/kgBehavioral: Altered sleep time (including change in righting reflex)ARZNAD 28,1579,1978
intraperitoneal/rat lethal dose (50 percent kill): 4420 mg/kgBehavioral: Toxic psychosis

Cardiac: Other changes

Kidney, Ureter, and Bladder: Other changes		RCOCB8 56,125,1987
intravenous/mouse lethal dose (50 percent kill): 4250 mg/kgJAPMA8 39,583,1950
intravenous/rabbit lethal dose (50 percent kill): 53 gm/kgNIIRDN 6,215,1982
intravenous/rat lethal dose (50 percent kill): 5566 mg/kgARZNAD 26,1581,1976
oral/guinea pig lethal dose (50 percent kill): 7750 mg/kgJIHTAB 23,259,1941
oral/human lowest published toxic dose: 1428 mg/kgBehavioral: Headache

Gastrointestinal: Nausea or vomiting		34ZIAG -,288,1969
oral/man lowest published toxic dose: 3.88 gm/kgBrain and Coverings: Changes in surface EEG

Behavioral: Excitement

Gastrointestinal: Hypermotility, diarrhea		JTCTDW 47,312,2009
oral/mouse lethal dose (50 percent kill): 4090 mg/kgFRZKAP (6),56,1977
oral/rabbit lethal dose (50 percent kill): 27 gm/kgDMDJAP 31,276,1959
oral/rat lethal dose (50 percent kill): 12600 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes		FEPRA7 4,142,1945
oral/rat lethal dose (50 percent kill): 12600 mg/kgENTOX* -,449,2005
subcutaneous/mouse lethal dose (50 percent kill): 91 mg/kgNIIRDN 6,215,1982
subcutaneous/rat lethal dose (50 percent kill): 100 mg/kgNIIRDN 6,215,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 560 gm/kg/8W- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiEXLRDA 12,281,1987
oral/mouse lowest published toxic dose: 2800 mg/kg/25W- continuousSkin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens		CALEDQ 155,61,2000
oral/rat lowest published toxic dose: 96 gm/kg/30D- intermittentBlood: Changes in leukocyte (WBC) count

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 49(10),81,1984

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWINMEAF 9,-,1940
TOXICOLOGY REVIEWTPHSDY 23,504,2002
TOXICOLOGY REVIEWTPHSDY 24,355,2003
TOXICOLOGY REVIEWENTOX* -,449,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,313,1998
Mine Safety and Health Administration (MSHA) STANDARDNUISANCE PARTICULATES (mist)DTLWS* 3,20,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 50 mg/m3, inhal, 2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3 (mist), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3 (inhalable), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3 (mist), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 mg/m3, KZG-week 100 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 35085; Number of Industries 310; Total Number of Facilities 67054; Number of Occupations 215; Total Number of Employees Exposed 2135546; Total Number of Female Employees Exposed 1346631
National Occupational Hazard Survey 1974Hazard Code 35085; Number of Industries 358; Total Number of Facilities 86657; Number of Occupations 198; Total Number of Employees Exposed 1085329

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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