Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, bromo-

RTECS #

PA4900000

CAS #

74-83-9

Updated

September 201

Molecular Weight

94.95

Molecular Formula

CH3Br

Synonyms

Bercema
Brom-methan (German)
Brom-O-Gas
Bromometano (Italian)
Bromomethane
Brom-O-Sol
Bromure de methyle (French)
Bromuro di metile (Italian)
Broommethaan (Dutch)
Celfume
Curafume
Dawson 100
Detia gas EX-M
Dowfume MC-2
Dowfume MC-2 soil fumigant
Dowfume MC-33
Embafume
Fumigant-1 (Obs.)
Halon 1001
Haltox
Iscobrome
Kayafume
Metafume
Methogas
Methyl bromide
Methyl bromide (ACGIH:OSHA)
Methylbromid (German)
Metylu bromek (Polish)
Monobromomethane
Pestmaster (Obs.)
Profume (Obs.)
R 40B1
RCRA waste number U029
Terabol
Terr-O-Cide II
Terr-O-Gas 100
Terr-O-Gas 67
Zytox

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human95 mg/LTCMUD8 10,21,1990
Cytogenetic Analysislung/hamster0.05 pph/6H (+enzymatic activation step)MUREAV 652,122,2008
Cytogenetic Analysislung/hamster0.1 pph/6H (-enzymatic activation step)MUREAV 652,122,2008
micronucleus testinhalation/rat338 ppm/6H/14D- intermittentMUREAV 164,269,1986
micronucleus testinhalation/mouse100 ppm/6H/14D- intermittentNTPTR* NTP-TR-385,1992
mutation in mammalian somatic cellslymphocyte/mouse300 µg/LMUREAV 155,41,1985
mutation in microorganisms/Salmonella typhimurium400 ppm (+enzymatic activation step)DHEFDK FDA-78-1046,1978
mutation in microorganisms/Salmonella typhimurium5000 mg/m3 (-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Klebsiella pneumoniae4750 mg/m3 (-enzymatic activation step)MUREAV 155,41,1985
other mutation test systems/Salmonella typhimurium3 pphENMUDM 9,171,1987
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster150 mg/m3/6HMUREAV 113,272,1983
sister chromatid exchangeinhalation/mouse200 ppm/6H/14D- intermittentNTPTR* NTP-TR-385,1992
sister chromatid exchangelymphocyte/human43000 ppmENMUDM 7(Suppl 3),48,1985
sister chromatid exchangelymphocyte/human5 mg/LTCMUD8 10,21,1990
specific locus testinhalation/Drosophila melanogaster8 mg/L/1H-continuousMUREAV 192,131,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 300 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleFCTOD7 36,421,1998
oral/rabbit 130 mg/kg (6-18D pregnant)Reproductive: Other effects on femaleFCTOD7 36,421,1998

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 30 ppm/6H/2.5Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors		NTIS** OTS0559186
oral/rat lowest published toxic dose: 3250 mg/kg/13W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Peritonitis

Gastrointestinal: Tumors		TXAPA9 72,262,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/child Lowest published lethal concentration: 1 gm/m3/2HBlood: Change in clotting factorsNHOZAX 23,241,1969
inhalation/guinea pig Lowest published lethal concentration: 300 ppm/9HBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Skin and Appendages: Other: Hair		XPHBAO 185,1,1929
inhalation/guinea pig Lowest published lethal concentration: 1200 mg/m3/9HLung, Thorax, or Respiration: Other changesVCVGH* -,575,1990
inhalation/human lowest published toxic concentration: 35 ppmBehavioral: Anorexia (human)

Gastrointestinal: Nausea or vomiting

Skin: After topical application: Corrosive		INMEAF 11,575,1942
inhalation/human Lowest published lethal concentration: 30000 mg/m3VCVGH* -,575,1990
inhalation/man Lowest published lethal concentration: 60000 ppm/2HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting		BJIMAG 2,24,1945
inhalation/mouse lowest published toxic concentration: 800 mg/m3Behavioral: General anestheticVCVGH* -,574,1990
inhalation/mouse Lowest published lethal concentration: 5200 mg/m3Behavioral: AtaxiaVCVGH* -,574,1990
inhalation/mouse lethal concentration (50 percent kill): 1540 mg/m3/2HVCVGH* -,574,1990
inhalation/mouse lethal concentration (50 percent kill): 4680 mg/m3/1HVCVGH* -,574,1990
inhalation/mouse lethal concentration (50 percent kill): 1700 ppm/30MENTOX* -,71,2005
inhalation/mouse lethal concentration (50 percent kill): 405 ppm/4HENTOX* -,71,2005
inhalation/rabbit Lowest published lethal concentration: 1000 mg/m3/30MVCVGH* -,575,1990
inhalation/rabbit lethal concentration (50 percent kill): 28900 mg/m3/30MFATOBP 8,140,1973
inhalation/rat lethal concentration (50 percent kill): 302 ppm/8HBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease		TXAPA9 81,183,1985
inhalation/rat lethal concentration (50 percent kill): 2250 mg/m3/2HVCVGH* -,575,1990
inhalation/rat lethal concentration (50 percent kill): 2833 ppm/30MENTOX* -,71,2005
inhalation/rat lethal concentration (50 percent kill): 302 ppm/8HENTOX* -,71,2005
intraperitoneal/mouse lethal dose (50 percent kill): 313 mg/kgVCVGH* -,572,1990
oral/Dog lowest published lethal dose: 500 mg/kgCardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature decrease		NTIS** OTS0528834
oral/rat lethal dose (50 percent kill): 214 mg/kgTXAPA9 72,262,1984
skin/human lowest published toxic dose: 35 gm/m3/40M- intermittentSkin: After systemic exposure: Dermatitis, irritativeARDEAC 124,917,1988
subcutaneous/rat lethal dose (50 percent kill): 135 mg/kgINHEAO 26,101,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 850 mg/m3/8H/26W- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Dyspnea		JIHTAB 22,218,1940
inhalation/monkey lowest published toxic concentration: 250 mg/m3/8H/26W- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold		JIHTAB 22,218,1940
inhalation/mouse lowest published toxic concentration: 200 ppm/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-385,1992
inhalation/mouse lowest published toxic concentration: 120 ppm/6H/13W- intermittentBehavioral: Muscle contraction or spasticity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		NTPTR* NTP-TR-385,1992
inhalation/mouse lowest published toxic concentration: 160 ppm/6H/6W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Endocrine: Other changes

Blood: Changes in spleen		FAATDF 11,594,1988
inhalation/rabbit lowest published toxic concentration: 130 mg/m3/8H/26W- intermittentPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		JIHTAB 22,218,1940
inhalation/rat lowest published toxic concentration: 120 ppm/6H/13W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTPTR* NTP-TR-385,1992
inhalation/rat lowest published toxic concentration: 150 ppm/6H/5D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)		TXAPA9 112,120,1992
inhalation/rat lowest published toxic concentration: 160 ppm/6H/6W- intermittentBrain and Coverings: Other degenerative changes

Olfaction: Other olfaction effects

Cardiac: Other changes		FAATDF 11,594,1988
inhalation/rat lowest published toxic concentration: 300 ppm/4H/3W- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TOLED5 6,293,1980
inhalation/rat lowest published toxic concentration: 290 ppm/4W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes		NRTXDN 28,252,2007
oral/rat lowest published toxic dose: 21840 mg/kg/2Y- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		FCTOD7 28,109,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,187,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,721,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 41,187,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,721,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,721,1999
TOXICOLOGY REVIEWTOLED5 134,3,2002
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWENTOX* -,71,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOPADD 33,517,2005
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 590,1,2005
TOXICOLOGY REVIEWNEUCL* 23,377,2005
TOXICOLOGY REVIEWNTAPM* -,239,1995
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWREPTED 31,392,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,132,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 15 ppm (60 mg/m3) (skin)DTLWS* 3,23,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (19 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (19 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (39 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (20 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 10 mg/m3, short term exposure limit 10 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (20 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 ppm (3.89 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (20 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 15 ppm (20 mg/m3);short term exposure limit 15 ppm (60 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (19 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (4 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 40 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (19 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (3.9 mg/m3), KZG-week 2 ppm (7.8 mg/m3), JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 20 ppm (80 mg/m3), JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 20 ppm (80 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 20 ppm (80 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 15 ppm (59 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 20 ppm (80 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 20 ppm (80 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 20 ppm (80 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 20 ppm (80 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL BROMIDE-airCarcinogen lowest feasible concentrationNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0420; Number of Industries 4; Total Number of Facilities 513; Number of Occupations 5; Total Number of Employees Exposed 5603; Total Number of Female Employees Exposed 975
National Occupational Hazard Survey 1974Hazard Code M0420; Number of Industries 10; Total Number of Facilities 597; Number of Occupations 14; Total Number of Employees Exposed 15899

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110682/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0493-8835
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse
NIOSH Analytical Method, 1994: Methyl bromide, 2520
NIOSH CURRENT INTELLIGENCE BULLETIN 43, 1984
On EPA IRIS database

Follow NIOSH

NIOSH Homepage

TOP