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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, dichlorodifluoro-

RTECS #

PA8200000

CAS #

75-71-8

Updated

September 201

Molecular Weight

120.91

Molecular Formula

CCl2F2

Synonyms

Algofrene type 2
Arcton 12
Arcton 6
CFC 12
Chlorofluorocarbon 12
Dichlorodifluoromethane
Dichlorodifluoromethane (ACGIH:OSHA)
Difluorodichloromethane
Dwuchlorodwufluorometan (Polish)
Dymel 12
Electro-CF 12
Eskimon 12
F 12
FC 12
FCC 12
FKW 12
Fluorocarbon-12
Forane 12
Freon 12
Freon F-12
Frigen 12
Genetron 12
Isceon 122
Isotron 12
Kaiser chemicals 12
Ledon 12
Propellant 12
R 12 (refrigerant)
RCRA waste number U075
Refrigerant R 12
Ucon 12
Ucon 12/halocarbon 12

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 37 pph/4MCardiac: Arrythmias (indlucing changes in conduction)

Cardiac: EKG changes not diagnostic of above		TXAPA9 29,242,1974
inhalation/Dog Lowest published lethal concentration: 4845000 mg/m3/10MVCVGH* -,621,1990
inhalation/guinea pig lethal concentration (50 percent kill): 80 pph/30MEJTXAZ 9,385,1976
inhalation/guinea pig lowest published toxic concentration: 106000 mg/m3/2HLung, Thorax, or Respiration: CoughVCVGH* -,621,1990
inhalation/guinea pig lowest published toxic concentration: 1430000 mg/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea		VCVGH* -,621,1990
inhalation/human lowest published toxic concentration: 200000 ppm/30MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Fibrosing alveolitis

Liver: Other changes		EJTXAZ 9,385,1976
inhalation/human lowest published toxic concentration: 431 mg/m3Brain and Coverings: Changes in surface EEGVCVGH* -,621,1990
inhalation/human lowest published toxic concentration: 49100 mg/m3/150MBehavioral: Somnolence (general depressed activity)VCVGH* -,621,1990
inhalation/human lowest published toxic concentration: 255000 mg/m3/5MCardiac: Arrythmias (indlucing changes in conduction)VCVGH* -,621,1990
inhalation/human lowest published toxic concentration: 561000 mg/m3/10MCardiac: Arrythmias (indlucing changes in conduction)VCVGH* -,621,1990
inhalation/mouse lethal concentration (50 percent kill): 3348 gm/m3/3HBehavioral: Sleep

Behavioral: Tremor

Behavioral: Excitement		GISAAA 28(6),95,1963
inhalation/mouse lowest published toxic concentration: 100 pph/10MCardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP		JAMAAP 214,81,1970
inhalation/mouse lowest published toxic concentration: 94500 mg/m3/24HLung, Thorax, or Respiration: CoughVCVGH* -,621,1990
inhalation/mouse lowest published toxic concentration: 324000 mg/m3/10MBehavioral: ExcitementVCVGH* -,621,1990
inhalation/mouse lowest published toxic concentration: 510000 mg/m3/3HBehavioral: Alteration of classical conditioningVCVGH* -,621,1990
inhalation/mouse lowest published toxic concentration: 2160000 mg/m3/1MBehavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement		VCVGH* -,621,1990
inhalation/mouse Lowest published lethal concentration: 3294000 mg/m3/2HVCVGH* -,621,1990
inhalation/mouse lethal concentration (16 percent kill): 3650000 mg/m3/2HVCVGH* -,621,1990
inhalation/mouse lethal concentration (50 percent kill): 3168000 mg/m3/2HVCVGH* -,621,1990
inhalation/rabbit lethal concentration (50 percent kill): 80 pph/30MEJTXAZ 9,385,1976
inhalation/rabbit lowest published toxic concentration: 255000 mg/m3/2MCardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section		VCVGH* -,621,1990
inhalation/rat Lethal concentration: >80 pph/4HNTIS** OTS0520424
oral/rat Lethal dose: >5600 µg/kgGISAAA 52(3),73,1987

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 3997 mg/m3/90D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 10,270,1967
inhalation/monkey lowest published toxic concentration: 3997 mg/m3/90D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestionTXAPA9 10,270,1967
inhalation/rabbit lowest published toxic concentration: 3997 mg/m3/90D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestionTXAPA9 10,270,1967
inhalation/rat lowest published toxic concentration: 4136 mg/m3/8H/6W- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 10,270,1967
inhalation/rat lowest published toxic concentration: 3997 mg/m3/90D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		TXAPA9 10,270,1967
oral/rat lowest published toxic dose: 2548 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 52(3),73,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1000 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAZMAE 18,365,1974
TOXICOLOGY REVIEWNYSJAM 74,1939,1974
TOXICOLOGY REVIEWENTOX* -,384,2005
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWHUTOX* -,577,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,312,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (4950 mg/m3)DTLVS* 3,78,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (4950 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (5000 mg/m3);KZW 2000 ppm (10000 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (5022 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 500 ppm (2475 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (5000 mg/m3), short term exposure limit 1300 ppm (6500 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (4950 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1000 ppm (5000 mg/m3), 2011
Occupational Exposure Limit-HUNGARYProhibited in Hungary, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 500 ppm (2475 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 500 ppm (2500 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (4950 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (4950 mg/m3);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (4950 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 500 ppm (2475 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (4045 mg/m3); short term exposure limit 1250 ppm (6181 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 4000 mg/m3, MAC(short term exposure limit) 6200 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (2500 mg/m3);short term exposure limit 750 ppm (4000 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (5000 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5040 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (4950 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (4950 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (4950 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (4950 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (4950 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (4950 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLORODIFLUOROMETHANE-air10H time-weighted average 1000 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 24095; Number of Industries 177; Total Number of Facilities 30739; Number of Occupations 140; Total Number of Employees Exposed 510790; Total Number of Female Employees Exposed 143439
National Occupational Hazard Survey 1974Hazard Code 24095; Number of Industries 403; Total Number of Facilities 139220; Number of Occupations 213; Total Number of Employees Exposed 1892483

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dichlorodifluoromethane, 1018
On EPA IRIS database

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