Registry of Toxic Effects of Chemical Substances (RTECS)

4,7-Methanoindene, 3a,4,7,7a-tetrahydro-

RTECS #

PC1050000

CAS #

77-73-6

Updated

September 201

Molecular Weight

132.22

Molecular Formula

C₁₀H₁₂

Synonyms

1,3-Cyclopentadiene, dimer
3a,4,7,7a-Tetrahydro-4,7-methanoindene
Bicyclopentadiene
Biscyclopentadiene
Dicyclopentadiene
Dicyclopentadiene (ACGIH)
Dicyklopentadien (Czech)
Dimer cyklopentadienu (Czech)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	9300 µg/24H open irritation test	severe	AIHAAP 23,95,1962
skin /rabbit	20 mg/24H	moderate	85JCAE -,50,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	22400 mg/kg (multigeneration)	Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	TOXID9 15,166,1995
oral/rat	2000 mg/kg (6-15D pregnant)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	HPV369 -,-,2001
oral/rabbit	1400 mg/kg (6-19D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Abortion	HPV369 -,-,2001
oral/rabbit	5600 mg/kg (6-19D pregnant)	Reproductive: Other effects on female Reproductive: Effects on fertility: Abortion Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	HPV369 -,-,2001

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	Lowest published lethal concentration: 773 ppm/1H		TXAPA9 20,552,1971
inhalation/guinea pig	lethal concentration (50 percent kill): 770 ppm/4H		TXAPA9 20,552,1971
inhalation/guinea pig	lethal concentration (50 percent kill): 2100 mg/m³		VCVGH* -,106,1990
inhalation/human	lowest published toxic concentration: 16 mg/m³	Behavioral: Headache	VCVGH* -,106,1990
inhalation/mouse	lethal concentration (50 percent kill): 130 ppm/6H	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression	HPV369 -,-,2001
inhalation/mouse	lethal concentration (50 percent kill): 400 mg/m³/2H		VCVGH* -,106,1990
inhalation/mouse	lethal concentration (50 percent kill): 145 ppm/4H		TXAPA9 20,552,1971
inhalation/rabbit	lethal concentration (50 percent kill): 771 ppm/4H		TXAPA9 20,552,1971
inhalation/rabbit	lethal concentration (50 percent kill): 4200 mg/m³		VCVGH* -,106,1990
inhalation/rat	lethal concentration (50 percent kill): 610 mg/m³/4H		VCVGH* -,106,1990
inhalation/rat	lethal concentration (50 percent kill): 660 ppm/4H	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay)	NTIS** OTS0557739
inhalation/rat	lethal concentration (50 percent kill): 284 ppm/6H	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression	HPV369 -,-,2001
intraperitoneal/mammal (species unspecified)	lethal dose (50 percent kill): 960 mg/kg		NTIS** AD-A087-257
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mg/kg		NCIUS* PH43-64-886
intraperitoneal/rat	lethal dose (50 percent kill): 200 mg/kg		NCIUS* PH43-64-886
oral/cattle	lethal dose (50 percent kill): 1200 mg/kg	Behavioral: Ataxia Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** AD-A093-673
oral/domestic bird	lethal dose (50 percent kill): 1010 mg/kg		NTIS** AD-A087-257
oral/mouse	lethal dose (50 percent kill): 190 mg/kg		VCVGH* -,106,1990
oral/rat	lethal dose (50 percent kill): 353 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness	TXAPA9 20,552,1971
oral/rat	lethal dose (50 percent kill): 520 mg/kg	Behavioral: Convulsions or effect on seizure threshold	VCVGH* -,106,1990
oral/rat	lethal dose (50 percent kill): 370 mg/kg		VCVGH* -,106,1990
skin/rabbit	lethal dose (50 percent kill): 5080 mg/kg	Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness	TXAPA9 20,552,1971
skin/rabbit	lethal dose (50 percent kill): 5.08 mL/kg		VCVGH* -,107,1990

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 72 ppm/7H/2W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 20,552,1971
inhalation/mouse	lowest published toxic concentration: 714 ppm/6H/11D- continuous	Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0536197
inhalation/mouse	lowest published toxic concentration: 51 ppm/13W- continuous	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV369 -,,2001
inhalation/rat	lowest published toxic concentration: 1 ppm/13W- continuous	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	HPV369 -,,2001
inhalation/rat	lowest published toxic concentration: 250 ppm/6H/2W- intermittent	Behavioral: Somnolence (general depressed activity) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BJIMAG 27,1,1970
inhalation/rat	lowest published toxic concentration: 35 ppm/7H/18W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight	TXAPA9 20,552,1971
inhalation/rat	lowest published toxic concentration: 5 ppm/6H/13W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Changes in: Na Nutritional and Gross Metabolic: Changes in: P	TIHEEC 8,353,1992
inhalation/rat	lowest published toxic concentration: 20 mg/m³/4H/26W- intermittent	Behavioral: Excitement Vascular: BP elevation not characterized in autonomic section Kidney, Ureter, and Bladder: Proteinuria	GTPZAB 9(12),13,1965
oral/rat	lowest published toxic dose: 182 mg/kg/26W- intermittent	Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	GISAAA 51(2),77,1986
oral/rat	lowest published toxic dose: 1120 mg/kg/28D- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	ESKHA5 (108),71,1990
oral/rat	lowest published toxic dose: 2000 mg/kg/10D- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV369 -,,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		NTAPM* -,629,1995

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 ppm (27 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 ppm (3 mg/m³);KZW 1 ppm (6 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 ppm (27 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.5 ppm (2.7 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 1 ppm (5.5 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 5 ppm (30 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.5 ppm (2.7 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.5 ppm (2.7 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 ppm (30 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 ppm (30 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 ppm (27 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 ppm (30 mg/m³), JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.5 ppm (3 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 3 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 5 ppm (27 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENE-air	10H time-weighted average 5 ppm	NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983	Hazard Code 83439; Number of Industries 4; Total Number of Facilities 252; Number of Occupations 8; Total Number of Employees Exposed 6248; Total Number of Female Employees Exposed 442
National Occupational Hazard Survey 1974	Hazard Code 83439; Number of Industries 24; Total Number of Facilities 2292; Number of Occupations 38; Total Number of Employees Exposed 41365

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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