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Registry of Toxic Effects of Chemical Substances (RTECS)

1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-

RTECS #

PC8575000

CAS #

143-50-0

Updated

December 2012

Molecular Weight

490.60

Molecular Formula

C10Cl10O

Synonyms

1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decano-4-one
Chlordecone
Ciba 8514
Clordecone
Compound 1189
Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
Decachloroketone
Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
Decachloropentacyclo(5.2.1.0(sup 2,6).0(sup 3,9).0(sup 5,8))decan-4-one
Decachloropentacyclo(5.3.0.0(sup 2,6).0(sup 4,10).0(sup 5,9))decan-3-one
Decachlorotetracyclodecanone
Decachlorotetrahydro-4,7-methanoindeneone
ENT 16,391
GC 1189
General chemicals 1189
Kepone
NCI-C00191
RCRA waste number U142

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
other mutation test systemsliver/rat100 µmol/LTIVIEQ 4,179,1990
sister chromatid exchangeovary/hamster1700 µg/LEMMUEG 10(Suppl 10),1,1987
specific locus testintraperitoneal/mouse71.3 µmol/LMUREAV 608,29,2006
sperm morphologyoral/quail200 ppm/42D-continuousTXAPA9 43,535,1978

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 25 mg/kg (1D prior to copulation)Reproductive: Other effects on femaleREPTED 5,65,1991
intraperitoneal/rat 50 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
NTOTDY 8,121,1986
intraperitoneal/rat 50 mg/kg (1D prior to copulation)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)REPTED 1,105,1987/1988
intraperitoneal/rat 75 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaREPTED 5,65,1991
intraperitoneal/rat 60 mg/kg (18-22D preg/7D after birth)Reproductive: Effects on newborn: PhysicalHBPTO* 1,733,2001
intraperitoneal/rat 5 mg/kg (16D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
NETEEC 29,255,2007
oral/mouse 16500 µg/kg (4W male/4W prior to copulation)Reproductive: Effects on fertility: Other measures of fertilityJEENAI 58,754,1965
oral/mouse 120 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 38,189,1976
oral/mouse 100 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JTEHD6 10,541,1982
oral/mouse 120 mg/kg (8-12D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 6,361,1986
oral/mouse 72 mg/kg (30D male/30D prior to copulation)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)HBPTO* 1,732,2001
oral/rat 105 mg/kg (14-20D pregnant)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
ENVRAL 18,437,1979
oral/rat 40 mg/kg (1D prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)VCVGK* -,483,1994
oral/rat 25 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathVCVGK* -,484,1994
oral/mouse 60 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathVCVGK* -,484,1994
oral/rat 47 mg/kg (60D pre-12D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
NRTXDN 3,131,1982
oral/rat 30.9 mg/kg (60D pre-21D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Delayed effects
NRTXDN 3,119,1982
oral/rat 88.2 mg/kg (7W male)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)FEPRA7 37,501,1978
oral/rat 63 mg/kg (2-22D preg/21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOLED5 4,247,1979
oral/rat 42 mg/kg (2-22D preg/21D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsTXAPA9 41,142,1977
oral/rat 100 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Homeostasis
TXAPA9 38,189,1976
oral/rat 60 mg/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 38,189,1976
oral/rat 17 mg/kg (1-22D preg/12D after birth)Reproductive: Effects on newborn: BehavioralFEPRA7 40,667,1981
oral/rat 18 mg/kg (5D male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TOLED5 30,237,1986
subcutaneous/rat 2 mg/kg (2D prior to copulation)Reproductive: Maternal effects: Uterus, cervix, vaginaENVRAL 16,131,1978
subcutaneous/rat 10 mg/kg (2D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesENVRAL 16,131,1978

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1200 mg/kg/80W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-b,1976
oral/mouse toxic dose: 1340 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
AIHAAP 37,680,1976
oral/mouse toxic dose: 1550 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
AIHAAP 37,680,1976
oral/mouse toxic dose: 1344 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JTEHD6 4,895,1978
oral/rat lowest published toxic dose: 200 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NEOLA4 26,231,1979
oral/rat toxic dose: 504 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
JTEHD6 4,895,1978
oral/rat toxic dose: 670 mg/kg/80W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-b,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 200 mg/kgEndocrine: Changes in spleen weight

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 183,1,2008
intraperitoneal/mouse lowest published toxic dose: 5 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 -,167,2008
intraperitoneal/mouse lowest published toxic dose: 15 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 233,193,2008
intraperitoneal/rat lowest published toxic dose: 500 mg/kgReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HBPTO* 1,733,2001
intraperitoneal/rat lowest published toxic dose: 80 mg/kgBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes
VCVGK* -,483,1994
intraperitoneal/rat lowest published toxic dose: 50 mg/kgEndocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NRTXDN 8,15,1987
intraperitoneal/rat lowest published toxic dose: 75 mg/kgEndocrine: Changes in adrenal weightNRTXDN 8,15,1987
intraperitoneal/rat lowest published toxic dose: 40 mg/kgBehavioral: TremorPSEBAA 195,44,1990
intraperitoneal/rat lowest published toxic dose: 60 mg/kgEndocrine: Other changes

Blood: Other changes
PSEBAA 195,44,1990
oral/chicken lethal dose (50 percent kill): 480 mg/kgENTOX* -,542,2005
oral/Dog lethal dose (50 percent kill): 250 mg/kgENTOX* -,542,2005
oral/Dog lethal dose (50 percent kill): 250 mg/kgBehavioral: TremorVCVGK* -,483,1994
oral/quail lethal dose (50 percent kill): 237 mg/kgJRPFA4 48,371,1976
oral/rabbit lethal dose (50 percent kill): 65 mg/kgPCOC** -,642,1966
oral/rabbit lethal dose (50 percent kill): 65 mg/kgBehavioral: TremorVCVGK* -,483,1994
oral/rat lethal dose (50 percent kill): 91300 µg/kgNTOTDY 5,91,1983
oral/rat lowest published toxic dose: 40 mg/kgEndocrine: Effect on menstrual cycleVCVGK* -,483,1994
oral/rat lethal dose (50 percent kill): 96 mg/kgBehavioral: TremorVCVGK* -,483,1994
oral/Trout lowest published toxic dose: 0.4 mg/kg/33WEndocrine: EstrogenicTIVIEQ 36,31,1996
skin/rabbit lethal dose (50 percent kill): 345 mg/kgGUCHAZ 6,96,1973
skin/rat lethal dose (50 percent kill): 2000 mg/kgVCVGK* -,483,1994
subcutaneous/rat lowest published toxic dose: 100 mg/kgBehavioral: TremorNRTXDN 3,111,1982
subcutaneous/rat lowest published toxic dose: 100 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Tremor

Endocrine: Other changes
NRTXDN 3,111,1982
subcutaneous/rat lowest published toxic dose: 75 mg/kgEndocrine: Other changesTXAPA9 100,506,1989
subcutaneous/rat lowest published toxic dose: 100 mg/kgEndocrine: Adrenal cortex hypoplasia

Endocrine: Other changes
NTOTDY 7,33,1985
unreported route/mammal (species unspecified) lowest published toxic dose: 25 mg/kgBrain and Coverings: Other degenerative changesVCVGK* -,483,1994
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 126 mg/kg30ZDA9 -,65,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 400 mg/kg/14W- continuousKidney, Ureter, and Bladder: Renal function tests depressedTXCYAC 218,81,2006
implant/mouse lowest published toxic dose: 40 mg/kg/60D- continuousImmunological Including Allergic: Autoimmune (multiple organ involvement)TXCYAC 218,81,2006
implant/mouse lowest published toxic dose: 120 mg/kg/22W- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes
TXCYAC 218,81,2006
intraperitoneal/mouse lowest published toxic dose: 83 mg/kg/10D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTXAPA9 49,151,1979
intraperitoneal/mouse lowest published toxic dose: 199.8 mg/kg/6D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTXAPA9 49,151,1979
intraperitoneal/mouse lowest published toxic dose: 277.6 mg/kg/4D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaTXAPA9 49,151,1979
intraperitoneal/mouse lowest published toxic dose: 160 mg/kg/20D- intermittentReproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes
TOSCF2 68,473,2002
intraperitoneal/mouse lowest published toxic dose: 80 mg/kg/2W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesTOXID9 60,383,2001
intraperitoneal/rat lowest published toxic dose: 12500 µg/kg/5D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)PCBPBS 18,113,1982
oral/Dog lowest published toxic dose: 560 mg/kg/2.5Y- continuousCardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 48,29,1979
oral/hamster lowest published toxic dose: 12 mg/kg/2D- intermittentEndocrine: EstrogenicHBPTO* 1,732,2001
oral/mouse lowest published toxic dose: 240 mg/kg/30D- intermittentEndocrine: Estrogenic

Endocrine: Effect on menstrual cycle
HBPTO* 1,732,2001
oral/mouse lowest published toxic dose: 180 mg/kg/18D- intermittentBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NRTXDN 2,113,1981
oral/mouse lowest published toxic dose: 150 mg/kg/3D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 6,275,1980
oral/mouse lowest published toxic dose: 320 mg/kg/10W- intermittentLiver: Changes in liver weightBECTA6 39,615,1987
oral/mouse lowest published toxic dose: 14 mg/kg/14D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)VCVGK* -,483,1994
oral/mouse lowest published toxic dose: 60 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,484,1994
oral/mouse lowest published toxic dose: 224 mg/kg/4W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesVCVGK* -,484,1994
oral/quail lowest published toxic dose: 1470 mg/kg/42D- continuousLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Related to Chronic Data: Changes in testicular weight
TXAPA9 43,535,1978
oral/rat lowest published toxic dose: 126 mg/kg/12W- continuousReproductive: Paternal effects: Testes, epididymis, sperm ductHBPTO* 1,732,2001
oral/rat lowest published toxic dose: 81 mg/kg/90D- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)HBPTO* 1,733,2001
oral/rat lowest published toxic dose: 307 mg/kg/15W- intermittentBehavioral: Alteration of operant conditioning

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature increase
NTOTDY 5,91,1983
oral/rat lowest published toxic dose: 912 mg/kg/2Y- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 48,29,1979
oral/rat lowest published toxic dose: 100 mg/kg/10D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decreased immune response
JTEHD6 15,561,1985
oral/rat lowest published toxic dose: 162 mg/kg/90D- continuousBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTXAPA9 59,262,1981
oral/rat lowest published toxic dose: 287 mg/kg/35D- continuousLiver: Other changes

Liver: Changes in liver weight
TXAPA9 58,132,1981
oral/rat lowest published toxic dose: 75 mg/kg/3D- intermittentBehavioral: Tremor

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
BECTA6 25,262,1980
oral/rat lowest published toxic dose: 25 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,484,1994
oral/rat lowest published toxic dose: 96.12 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Blood: Other changes
JESEDU A22,639,1987
oral/rat lowest published toxic dose: 49.06 mg/kg/10D- intermittentLiver: Changes in liver weightJESEDU A22,639,1987
oral/rat lowest published toxic dose: 1.68 mg/kg/28D- continuousLiver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JTEHD6 6,421,1980
oral/rat lowest published toxic dose: 1600 mg/kg/8D- continuousLiver: Other changes

Endocrine: Other changes
VCVGK* -,484,1994
oral/rat lowest published toxic dose: 140 mg/kg/14D- continuousLiver: Other changes

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,484,1994
oral/rat lowest published toxic dose: 140 mg/kg/14D- continuousLiver: Other changes

Endocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,484,1994
oral/rat lowest published toxic dose: 9 mg/kg/15D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHBPTO* 1,880,2001
oral/rat lowest published toxic dose: 31.5 mg/kg/105D- continuousBrain and Coverings: Other degenerative changesNRTXDN 3,119,1982
oral/rat lowest published toxic dose: 50.4 mg/kg/4W- continuousEndocrine: AndrogenicFEPRA7 37,501,1978
oral/rat lowest published toxic dose: 84 mg/kg/8W- continuousEndocrine: Effect on menstrual cycleFEPRA7 37,501,1978
oral/rat lowest published toxic dose: 105 mg/kg/10W- continuousEndocrine: Estrogenic

Endocrine: Change in LH

Related to Chronic Data: Changes in uterine weight
FEPRA7 37,501,1978
skin/rat lowest published toxic dose: 75 mg/kg/15D- intermittentRelated to Chronic Data: Changes in testicular weightVCVGK* -,484,1994
subcutaneous/mouse lowest published toxic dose: 3 mg/kg/3D- intermittentRelated to Chronic Data: Changes in uterine weight

Endocrine: Estrogenic
EVHPAZ 104,1296,1996
unreported route/mouse lowest published toxic dose: 840 mg/kg/4W- intermittentLiver: Other changes

Liver: Tumors
VCVGK* -,484,1994
unreported route/mouse lowest published toxic dose: 6 mg/kg/10D- continuousReproductive: Maternal effects: Uterus, cervix, vaginaHBPTO* 1,732,2001
unreported route/rat lowest published toxic dose: 700 mg/kg/4W- intermittentBehavioral: TremorVCVGK* -,484,1994
unreported route/rat lowest published toxic dose: 2250 mg/kg/90D- intermittentLiver: Changes in liver weightVCVGK* -,484,1994
unreported route/rat lowest published toxic dose: 730 mg/kg/2Y- intermittentLiver: TumorsVCVGK* -,484,1994

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 20,67,1979
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 20,67,1979
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWSTEVA8 9,1,1978
TOXICOLOGY REVIEWJTEHD6 4,895,1978
TOXICOLOGY REVIEWCTOXAO 13,231,1978
TOXICOLOGY REVIEWJEPTDQ 2(3),671,1979
TOXICOLOGY REVIEWENTOX* -,542,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHETOEA 25,413,2006
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWTPHSDY 29,116,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KEPONE-air10H Carcinogen time-weighted average 0.001 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code M2969; Number of Industries 1; Total Number of Facilities 280; Number of Occupations 2; Total Number of Employees Exposed 12600

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264354)
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-human
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8899
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Kepone, 5508
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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