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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Norbornene, 5-ethylidene-

RTECS #

RB9450000

CAS #

16219-75-3

Updated

September 201

Molecular Weight

120.21

Molecular Formula

C9H12

Synonyms

5-Ethylidene-2-norbornene
5-Ethylidenebicyclo(2.2.1)hept-2-ene
Bicyclo(2.2.1)hept-2-ene, 5-ethylidene- (9CI)
Ethylidene norbornene
Ethylidene norbornene (ACGIH)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 445 mg open irritation test mildUCDS** 11/28/1967

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 ppm/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system		IOMTE3 4,371,1995

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lethal concentration (50 percent kill): 15600 mg/m3/90MVCVGH* -,104,1990
inhalation/Dog lowest published toxic concentration: 10500 mg/m3/30MBehavioral: Convulsions or effect on seizure threshold

Skin: After topical application: Primary irritation		VCVGH* -,104,1990
inhalation/Dog lowest published toxic concentration: 6200 mg/m3/90MBehavioral: Convulsions or effect on seizure thresholdVCVGH* -,104,1990
inhalation/guinea pig lethal concentration (50 percent kill): 2896 ppm/4HEye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold		TXAPA9 20,250,1971
inhalation/human lowest published toxic concentration: 6 ppm/30MOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Taste: Change in function		TXAPA9 20,250,1971
inhalation/human lowest published toxic concentration: 27 mg/m3/30MEye: Conjunctiva irritationVCVGH* -,104,1990
inhalation/mouse lethal concentration (50 percent kill): 10900 mg/m3/2HVCVGH* -,104,1990
inhalation/mouse lethal concentration (50 percent kill): 732 ppm/4HBehavioral: Muscle weaknessTXAPA9 20,250,1971
inhalation/rabbit lethal concentration (50 percent kill): 3104 ppm/4HOlfaction: Ulcerated nasal septumTXAPA9 20,250,1971
inhalation/rat lethal concentration (50 percent kill): 3520 mg/m3/4HVCVGH* -,104,1990
inhalation/rat lethal concentration (50 percent kill): 1246 ppm/4HBehavioral: Muscle weaknessTXAPA9 20,250,1971
intraperitoneal/rat lethal dose (50 percent kill): 2830 µL/kgNTIS** OTS0536403
oral/mouse lethal dose (50 percent kill): 3040 mg/kgVCVGH* -,104,1990
oral/rat lethal dose (50 percent kill): 2830 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 5.66 mL/kgVCVGH* -,104,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 61 ppm/7H/89D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases		NTIS** OTS0536403
inhalation/rat lowest published toxic concentration: 52 ppm/6H/9D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Evidence of thyroid hyperfunction		JJATDK 17,197,1997
inhalation/rat lowest published toxic concentration: 359 ppm/6H/66D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionJJATDK 17,197,1997
inhalation/rat lowest published toxic concentration: 149 ppm/6H/66D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight		JJATDK 17,197,1997
inhalation/rat lowest published toxic concentration: 359 ppm/6H/9D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJJATDK 17,197,1997
inhalation/rat lowest published toxic concentration: 24.8 ppm/6H/66D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJJATDK 17,197,1997
inhalation/rat lowest published toxic concentration: 50 ppm/6H/9D- intermittentEndocrine: Other changesJAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 150 ppm/6H/9D- intermittentLiver: Other changes

Endocrine: Changes in thyroid weight		JAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 359 ppm/6H/9D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Normocytic anemia		JAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 50 ppm/6H/9D- intermittentEndocrine: Changes in thyroid weightJAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 359 ppm/6H/9D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 4.9 ppm/6H/14W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightJAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 24.8 ppm/6H/14W- intermittentEndocrine: Other changes

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		JAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 149 ppm/6H/14W- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Changes in liver weight		JAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 4.9 ppm/6H/14W- intermittentEye: Other eye effectsJAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 24.8 ppm/6H/14W- intermittentBlood: Changes in erythrocyte (RBC) countJAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 149 ppm/6H/14W- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in kidney weight		JAPTO* 17,197,1997
inhalation/rat lowest published toxic concentration: 90 ppm/7H/88D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		TXAPA9 20,250,1971
inhalation/rat lowest published toxic concentration: 350 ppm/6H/11D- intermittentEndocrine: Changes in thyroid weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0536403
oral/rat lowest published toxic dose: 4200 mg/kg/14D- continuousLiver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0538294-1

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 5 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 5 ppm (25 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (25 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 5 ppm (25 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 5 ppm (25 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 5 ppm (25 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 5 ppm (25 mg/m3), NOV2011
Occupational Exposure Limit-KOREAceiling concentration 5 ppm (25 mg/m3), 2006
Occupational Exposure Limit-MEXICOpeak 5 ppm (25 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 5 ppm (25 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 5 ppm (25 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (25 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 25 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLIDENE NORBORNENE-airceiling concentration 5 ppmNIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974Hazard Code M3889; Number of Industries 1; Total Number of Facilities 22; Number of Occupations 20; Total Number of Employees Exposed 1988

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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