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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoric acid

RTECS #

TB6300000

CAS #

7664-38-2

Updated

September 201

Molecular Weight

98.00

Molecular Formula

H3O4P

Synonyms

Acide phosphorique (French)
Acido fosforico (Italian)
Fosforzuuroplossingen (Dutch)
Hydrogen phosphate
Orthophosphoric acid
Phosphoric acid (ACGIH:OSHA)
Phosphorsaeureloesungen (German)

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 14 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mouse lethal concentration (50 percent kill): 25.5 mg/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight		VCVN5* -,73,1993
inhalation/rat lethal concentration (50 percent kill): 25.5 mg/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight		VCVN5* -,73,1993
oral/mouse lethal dose (50 percent kill): 1.25 gm/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight		VCVN5* -,73,1993
oral/rat lethal dose (50 percent kill): 1.25 gm/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight		VCVN5* -,73,1993
unreported route/man lowest published lethal dose: 220 mg/kg85DCAI 2,73,1970

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3;short term exposure limit 3 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWARTODN 39,299,1978
TOXICOLOGY REVIEWCHHSA* 11,35,2004

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,325,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg/m3DTLVS* 3,210,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 mg/m3;KZW 2 mg/m3, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 mg/m3, MAY2011
Occupational Exposure Limit-ECtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 ppm (1 mg/m3), VLE 0.5 ppm (2 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 mg/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg/m3;short term exposure limit 3 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1 mg/m3; short term exposure limit 3 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 1 mg/m3;short term exposure limit 3 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg/m3, KZG-week 2 mg/m3, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 mg/m3;short term exposure limit 2 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORIC ACID-air10H time-weighted average 1 mg/m3;short term exposure limit 3 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 58520; Number of Industries 309; Total Number of Facilities 61396; Number of Occupations 198; Total Number of Employees Exposed 1256907; Total Number of Female Employees Exposed 450478
National Occupational Hazard Survey 1974Hazard Code 58520; Number of Industries 257; Total Number of Facilities 42406; Number of Occupations 146; Total Number of Employees Exposed 454920

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-111

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