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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorodithioic acid, S,S'-methylene O,O,O',O'-tetraethyl ester

RTECS #

TE4550000

CAS #

563-12-2

Updated

September 201

Molecular Weight

384.49

Molecular Formula

C9H22O4P2S4

Synonyms

Bis(S-(diethoxyphosphinothioyl)mercapto)methane
Diethion
Embathion
ENT 24,105
Ethanox
Ethiol 100
Ethion
Ethion (ACGIH)
Ethodan
Ethopaz
Ethyl methylene phosphorodithioate
FMC-1240
Fosfatox E
Fosfono 50
Hylemox
KWIT
Methyleen-S,S'-bis(O,O-diethyl-dithiofosfaat) (Dutch)
Methylene-S,S'-bis(O,O-diaethyl-dithiophosphat) (German)
NIA 1240
Niagara 1240
Nialate
O,O,O',O'-Tetraaethyl-bis(dithiophosphat) (German)
O,O,O',O'-Tetraethyl S,S'-methylene di(phosphorodithioate)
O,O,O',O'-Tetraethyl S,S'-methylenebisphosphordithioate
O,O,O',O'-Tetraethyl-S,S'-methylenebisphosphorodithioate
Phosphorodithioic acid, O,O-diethyl ester, S,S-diester with methanedithiol
Phosphotox E
Rhodocide
Rodocid
RP 8167
S,S'-Methylen-bis(O,O-diaethyl-dithiophosphat) (German)
S,S'-Methylene O,O,O',O'-tetraethyl phosphorodithioate
Tafethion
Tetraethyl S,S'-methylene bis(phosphorothiolothionate)
Vegfru fosmite

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 864 mg/m3FMCHA2 -,C128,1991
intraperitoneal/mouse lethal dose (50 percent kill): 35 mg/kgPSEBAA 129,699,1968
intraperitoneal/rat lethal dose (50 percent kill): 26 mg/kgPSEBAA 129,699,1968
oral/guinea pig lethal dose (50 percent kill): 40 mg/kg85DPAN -,-,1971/1976
oral/human lowest published toxic dose: 100 µg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 22,286,1972
oral/infant lowest published toxic dose: 15700 µg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature increase		TXMDAX 63,71,1967
oral/mouse lethal dose (50 percent kill): 40 mg/kg85DPAN -,-,1971/1976
oral/rat lethal dose (50 percent kill): 13 mg/kgPHJOAV 185,361,1960
oral/wild bird lethal dose (50 percent kill): 45 mg/kgTXAPA9 21,315,1972
skin/guinea pig lethal dose (50 percent kill): 915 mg/kg85DPAN -,-,1971/1976
skin/rat lethal dose (50 percent kill): 62 mg/kgTXAPA9 14,515,1969
unreported route/rat lethal dose (50 percent kill): 55 mg/kg30ZDA9 -,367,1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 675 mg/kg/90D- continuousBlood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		TOXID9 8,173,1988
oral/Dog lowest published toxic dose: 182 mg/kg/1Y- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		TOXID9 8,173,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAQMOAC #73-19,1973
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,117,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.4 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.4 mg/m3;KZW 0.8 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.4 mg/m3, skin, MAY2011
Occupational Exposure Limit-FRANCEVME 0.4 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.4 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.4 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.4 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.4 mg/m3, skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 0,4 mg/m3, JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.4 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.4 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHION-air10H time-weighted average 0.4 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974Hazard Code 84542; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108024)
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database

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