Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-diethyl O-(2-(ethylthio)ethyl) ester, mixed with O,O-diethyl S-(2-(ethylthio)ethyl) phosphorothioate (7:3)

RTECS #

TF3150000

CAS #

8065-48-3; 8000-97-3; 8058-73-9

Updated

September 201

Molecular Weight

516.72

Molecular Formula

C₈H₁₉O₃PS₂·C₈H₁₉O₃PS₂

Synonyms

Bayer 8169
Demeton
Demeton (ACGIH:OSHA)
Diethoxy thiophosphoric acid ester of 2-ethylmercaptoethanol
E 1059
ENT 17,295
Ethyl systox
Mercaptofos
Mercaptophos
O,O-Diethyl 2-ethylmercaptoethyl thiophosphate
O,O-Diethyl O(and S)-2-(ethylthio)ethyl phosphorothioate mixture
Septox
Systox
Systox (OSHA)

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	500 ppm	NTIS** PB84-138973
mutation in mammalian somatic cells	lymphocyte/mouse	80 mg/L	NTIS** PB84-138973
mutation in microorganisms	/Saccharomyes cerevisiae	500 ppm (+/-enzymatic activation step)	NTIS** PB84-138973
sister chromatid exchange	ovary/hamster	25 ppm	NTIS** PB84-138973
sister chromatid exchange	lung/hamster	10 mg/L	MUREAV 88,307,1981

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	10 mg/kg (11D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Gastrointestinal system Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 24,324,1973
parenteral/mouse	10 mg/kg (7D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	ANREAK 169,285,1971
parenteral/mouse	7 mg/kg (11D pregnant)	Reproductive: Specific developmental abnormalities: Gastrointestinal system	ANREAK 169,285,1971

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/cat	Lowest published lethal concentration: 15 mg/m³/4H		85GMAT -,52,1982
inhalation/mouse	lethal concentration (50 percent kill): 0.01 gm/m³/2H		TPKVAL 9,7,1967
inhalation/mouse	lethal concentration (50 percent kill): 0.96 ppm/2H		TPKVAL 9,7,1967
inhalation/rat	Lowest published lethal concentration: 15 mg/m³/4H		85GMAT -,52,1982
intramuscular/cat	lethal dose (50 percent kill): 3900 µg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting	13ZGAF -,220,1962
intramuscular/Dog	lethal dose (50 percent kill): 3650 µg/kg	Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting	13ZGAF -,220,1962
intramuscular/rat	lowest published lethal dose: 3 mg/kg	Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting	13ZGAF -,220,1962
intraperitoneal/mouse	lethal dose (50 percent kill): 4 mg/kg		PSEBAA 129,699,1968
intraperitoneal/rabbit	lethal dose (50 percent kill): 3250 µg/kg		BLLIAX 38,151,1958
intraperitoneal/rat	lethal dose (50 percent kill): 2500 µg/kg		APCRAW 4,117,1961
intravenous/mouse	lethal dose (50 percent kill): 3900 µg/kg		BLLIAX 38,151,1958
intravenous/rat	lethal dose (50 percent kill): 1750 µg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea	BLLIAX 38,151,1958
oral/duck	lethal dose (50 percent kill): 7190 µg/kg		TXAPA9 47,451,1979
oral/human	lowest published lethal dose: 171 µg/kg		CMEP** -,1,1956
oral/man	lowest published toxic dose: 144 mg/kg/24D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 14,603,1969
oral/mouse	lethal dose (50 percent kill): 7850 µg/kg		BLLIAX 38,151,1958
oral/pigeon	lethal dose (50 percent kill): 8480 µg/kg		TXAPA9 20,57,1971
oral/quail	lethal dose (50 percent kill): 8480 µg/kg		TXAPA9 20,57,1971
oral/rabbit	lethal dose (50 percent kill): 5 mg/kg		GISAAA 27(8),97,1962
oral/rat	lethal dose (50 percent kill): 1700 µg/kg		TXAPA9 21,315,1972
oral/wild bird	lethal dose (50 percent kill): 1780 µg/kg		ASTTA8 (680),157,1979
skin/rabbit	lethal dose (50 percent kill): 24 mg/kg		SPEADM 78-1,28,1978
skin/rat	lethal dose (50 percent kill): 8200 µg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement	TXAPA9 2,88,1960
skin/wild bird	lethal dose (50 percent kill): 1800 µg/kg		TXAPA9 26,154,1973
subcutaneous/mouse	lethal dose (50 percent kill): 15 mg/kg		APFRAD 11,286,1953
subcutaneous/rabbit	lethal dose (50 percent kill): 24 mg/kg		IAEC** 17JUN1974

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 7.9 mg/kg/168D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 1,59,2001
oral/human	lowest published toxic dose: 1.2 mg/kg/24D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 1,59,2001
oral/rat	lowest published toxic dose: 15.68 mg/kg/112D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	HBPTO* 1,59,2001

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.05 mg/m³ (inhal, vapor, skin)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		AQMOAC #73-19,1973
TOXICOLOGY REVIEW		RREVAH 46,1,1973
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		TOLED5 190,107,2009

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,109,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.01 ppm (0.1 mg/m³) (skin)	DTLWS* 3,15,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.01 ppm (0.11 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.01 ppm (0.1 mg/m³);KZW 0.1 ppm (1 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.05 mg/m³ (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.01 ppm (0.1 mg/m³), skin, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.1 mg/m³, short term exposure limit 0.3 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.01 ppm (0.1 mg/m³), Skin, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.01 ppm (0.1 mg/m³), skin, NOV2011
Occupational Exposure Limit-INDIA	time-weighted average 0.01 ppm (0.1 mg/m³), Skin, JAN1993
Occupational Exposure Limit-KOREA	time-weighted average 0.01 ppm (0.1 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.01 ppm (0.1 mg/m³);short term exposure limit 0.03 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.01 ppm (0.11 mg/m³), skin, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.005 ppm (0.05 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.02 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.01 ppm (0.1 mg/m³), skin, JAN2011
Occupational Exposure Limit-THAILAND	time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.1 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 0.1 mg/m³, Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 0.1 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.1 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.1 mg/m³ (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.1 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.1 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DEMETON-air	10H time-weighted average 0.1 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
NIOSH Analytical Method, 1994: Demeton, 5514
On EPA IRIS database

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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