Registry of Toxic Effects of Chemical Substances (RTECS)
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Phosphorothioic acid, O,O-diethyl O-(p-nitrophenyl) ester
RTECS #
TF4550000CAS #
56-38-2; 8057-70-3; 11111-91-4; 110616-89-2Updated
December 2013Molecular Weight
291.28Molecular Formula
C10H14NO5PSSynonyms
AATPAlkron
Alleron
American cyanamid 3422
Aphamite
Aralo
B 404
Bay 1605
BAY E-605
Bayer E-605
Bladan F
Compound 3422
Diethyl 4-nitrophenyl phosphorothionate
Diethyl para-nitrophenol thiophosphate
Diethyl p-nitrophenyl phosphorothionate
Diethyl p-nitrophenyl thionophosphate
Diethyl p-nitrophenyl thiophosphate
Diethylparathion
Dietil tiofosfato de p-nitrofenila (Portuguese)
Drexel parathion 8E
E 605
E 605 F
E 605 forte
Ekatin WF & WF ULV
Ekatox
ENT 15,108
Ethyl parathion
Etilon
Etylparation (Czech)
Folidol
Folidol E
Folidol E605
Folidol oil
Fosferno
Fosfex
Fostern
Gearphos
Kolphos
Lethalaire G-54
Lirothion
Murfos
NCI-C00226
Niran
Niran E-4
Nitrostigmin (German)
Nitrostigmine
NIUIF-100
Nourithion
O,O-Diaethyl-O-(4-nitro-phenyl)-monothiophosphat (German)
O,O-Diethyl O-(p-nitrophenyl) phosphorothioate
O,O-Diethyl O-4-nitrophenyl thiophosphate
O,O-Diethyl O-p-nitrophenyl thiophosphate
O,O-Diethyl-O-(4-nitro-fenil)-monothiofosfaat (Dutch)
O,O-Diethyl-O-(4-nitrophenyl) phosphorothioate
O,O-Diethyl-O-(p-nitrophenyl)thionophosphate
O,O-Diethyl-O-p-nitrofenylester kyseliny thiofosforecne (Czech)
O,O-Dietil-O-(4-nitro-fenil)-monotiofosfato (Italian)
O,O-Dietyl-O-p-nitrofenyltiofosfat (Czech)
Oleofos 20
Oleoparaphene
Oleoparathion
OMS 19
Orthophos
Pacol
Panthion
Paradust
Paramar 50
Paraphos
Parathene
Parathion
Parathion (ACGIH:OSHA)
Parathion-aethyl (German)
Parathion-ethyl
Parawet
Penncap E
Pestox plus
Pethion
Phenol, p-nitro-, O-ester with O,O-diethylphosphorothioate
Phoskil
Phosphemol
Phosphenol
Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl) ester
Phosphostigmine
RB
RCRA waste number P089
Rhodiasol
Rhodiatox
Selephos
SNP
Soprathion
Stabilized ethyl parathion
Super Rodiatox
T-47
Thiofos
Thiomex
Thiophos
Thiophos 3422
Thiophosphate de O,O-diethyle et de O-(4-nitrophenyle) (French)
Vitrex
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | oral/rat | 10 mg/kg/28D- intermittent | MUREAV 53,175,1978 |
| DNA Damage | intraperitoneal/rat | 3 µg/kg | MUREAV 53,175,1978 |
| DNA Damage | oral/mouse | 20 mg/kg/28D- intermittent | MUREAV 53,175,1978 |
| DNA Damage | intraperitoneal/mouse | 3 µg/kg | MUREAV 53,175,1978 |
| DNA Damage | lymphocyte/rat | 10 µmol/L/16H | JAPTO* 23,23,2003 |
| DNA Damage | lymphocyte/mouse | 10 µmol/L/16H | JAPTO* 23,23,2003 |
| mutation in microorganisms | /Salmonella typhimurium | 1 mg/plate (+enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
| mutation in microorganisms | /Salmonella typhimurium | 500 µg/plate (-enzymatic activation step) | JTEHD6 16,403,1985 |
| sister chromatid exchange | ovary/hamster | 300 µmol/L | JTEHD6 8,939,1981 |
| sister chromatid exchange | lymphocyte/human | 200 µg/L | MUREAV 102,89,1982 |
| Unscheduled DNA Synthesis | fibroblast/human | 10 µmol/L | NTIS** PB268-647 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 3 mg/kg (11D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | AEHLAU 16,805,1968 |
| intraperitoneal/rat | 3 mg/kg (11D pregnant) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Other effects on female Nutritional and Gross Metabolic: Weight loss or decreased weight gain | AEHLAU 16,805,1968 |
| intraperitoneal/rat | 3500 µg/kg (11D pregnant) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | AEHLAU 16,805,1968 |
| intraperitoneal/rat | 980 µg/kg (9D pregnant) | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | AJOGAH 96,1148,1966 |
| oral/rat | 360 µg/kg (2-22D preg/15D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | TOLED5 3,11,1979 |
| oral/rat | 2304 µg/kg (16D prior to copulation) | Reproductive: Maternal effects: Uterus, cervix, vagina | TOERD9 3,279,1981 |
| oral/rat | 22 mg/kg (1-22D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | JJATDK 9,401,1989 |
| subcutaneous/rat | 6 mg/kg (13-16D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | PWPSA8 16,141,1973 |
| subcutaneous/rat | 9800 µg/kg (7-13D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | OYYAA2 6,667,1972 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | lowest published toxic dose: 1260 mg/kg/80W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Adrenal cortex tumors | NCITR* NCI-TR-70,1979 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | Lethal concentration: >37130 µg/m3/4H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** AD-A041-973 |
| inhalation/guinea pig | Lowest published lethal concentration: 14 mg/m3/2H | AMIHBC 5,44,1952 | |
| inhalation/mouse | Lowest published lethal concentration: 15 mg/m3 | 85GMAT -,52,1982 | |
| inhalation/rabbit | Lowest published lethal concentration: 50 mg/m3/2H | AMIHBC 5,44,1952 | |
| inhalation/rat | lethal concentration (50 percent kill): 84 mg/m3/4H | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | NTIS** AD-A041-973 |
| intramuscular/domestic animal | lowest published lethal dose: 20 mg/kg | Eye: Miosis (pupilliary constriction) Behavioral: Muscle weakness Behavioral: Rigidity (includes catalepsy) | MRLR** #269,1954 |
| intramuscular/mouse | lethal dose (50 percent kill): 7200 µg/kg | AEPPAE 237,211,1959 | |
| intramuscular/rat | lethal dose (50 percent kill): 6 mg/kg | JCINAO 37,350,1958 | |
| intraperitoneal/cat | lethal dose (50 percent kill): 3 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | JPETAB 95,79,1949 |
| intraperitoneal/chicken | lethal dose (50 percent kill): 2500 µg/kg | EQSFAP 3,173,1974 | |
| intraperitoneal/Dog | lethal dose (50 percent kill): 12 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Respiratory depression | JPETAB 95,79,1949 |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 12 mg/kg | ARZNAD 5,626,1955 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 3 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JAFCAU 11,91,1963 |
| intraperitoneal/mouse | lowest published toxic dose: 10 mg/kg | Behavioral: Tremor | TXAPA9 227,42,2008 |
| intraperitoneal/rat | lowest published toxic dose: 1660.3 µg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 253,8,2008 |
| intraperitoneal/rat | lethal dose (50 percent kill): 2 mg/kg | APCRAW 4,117,1961 | |
| intraperitoneal/rat | lowest published toxic dose: 2 mg/kg | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,314,2002 |
| intratracheal/human | lowest published lethal dose: 714 µg/kg | SKEZAP 9,1,1968 | |
| intratracheal/rat | lethal dose (50 percent kill): 6200 µg/kg | JJATDK 19,133,1999 | |
| intravenous/cat | lethal dose (50 percent kill): 3 mg/kg | Eye: Lacrimation Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation | JAMAAP 144,104,1950 |
| intravenous/Dog | lethal dose (50 percent kill): 12 mg/kg | Eye: Lacrimation Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory stimulation | JAMAAP 144,104,1950 |
| intravenous/mouse | lethal dose (50 percent kill): 13 mg/kg | ENTOX* ,706,2005 | |
| intravenous/rat | lethal dose (50 percent kill): 3800 µg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | CJBPAZ 34,197,1956 |
| oral/cat | lethal dose (50 percent kill): 0.93 mg/kg | ENTOX* -,331,2005 | |
| oral/chicken | lethal dose (50 percent kill): 10 mg/kg | EQSFAP 3,173,1974 | |
| oral/Dog | lethal dose (50 percent kill): 3 mg/kg | SPEADM 78-1,33,1978 | |
| oral/domestic animal | lowest published lethal dose: 100 mg/kg | Behavioral: Excitement Behavioral: Rigidity (includes catalepsy) Lung, Thorax, or Respiration: Dyspnea | MRLR** #269,1954 |
| oral/duck | lethal dose (50 percent kill): 2100 µg/kg | DOEAAH 35,25,1979 | |
| oral/guinea pig | lethal dose (50 percent kill): 8 mg/kg | ARZNAD 5,626,1955 | |
| oral/horse, donkey | lethal dose (50 percent kill): 5 mg/kg | 85DPAN -,-,1971/1976 | |
| oral/human | lowest published lethal dose: 171 µg/kg | CMEP** -,1,1956 | |
| oral/human | lethal dose (50 percent kill): 3 mg/kg | 85JFAN A311,1986 | |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): 49 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia | NTIS** PB288-416 |
| oral/man | lowest published toxic dose: 2143 mg/kg | Behavioral: Coma Cardiac: Pulse rate decreased with fall in BP Vascular: Shock | NEURAI 31,603,1981 |
| oral/man | lowest published toxic dose: 214 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Change in motor activity (specific assay) Behavioral: Coma | JNNPAU 56,1135,1993 |
| oral/man | lowest published toxic dose: 429 µg/kg/4D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 14,603,1969 |
| oral/mouse | lethal dose (50 percent kill): 5 mg/kg | ABCHA6 30,181,1966 | |
| oral/mouse | lowest published toxic dose: 4 mg/kg | Immunological Including Allergic: Decreased immune response | JTEHF8 68,2187,2005 |
| oral/pigeon | lethal dose (50 percent kill): 1330 µg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 4040 µg/kg | PCBPBS 7,28,1977 | |
| oral/quail | lowest published toxic dose: 5 mg/kg | Endocrine: Change in LH | CBCPAI 83C,451,1986 |
| oral/quail | lowest published lethal dose: 10 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Eye: Lacrimation Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | CBCPAI 83C,451,1986 |
| oral/rabbit | lethal dose (50 percent kill): 10 mg/kg | ENTOX* -,331,2005 | |
| oral/rat | lowest published toxic dose: 0.35 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 210,142,2006 |
| oral/rat | lowest published toxic dose: 0.35 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 210,142,2006 |
| oral/rat | lowest published lethal dose: 0.5 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 210,142,2006 |
| oral/rat | lowest published lethal dose: 0.5 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,308,2003 |
| oral/rat | lethal dose (50 percent kill): 2 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 11,546,1967 |
| oral/rat | lethal dose (50 percent kill): 9 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| oral/wild bird | lethal dose (50 percent kill): 1330 µg/kg | ASTTA8 (680),157,1979 | |
| oral/woman | lowest published lethal dose: 2350 µL/kg | Behavioral: Coma Cardiac: Pulse rate increased without fall in BP Lung, Thorax, or Respiration: Respiratory depression | HETOEA 17,587,1998 |
| oral/woman | lowest published toxic dose: 2 mL/kg | Eye: Miosis (pupilliary constriction) Behavioral: Muscle weakness Behavioral: Coma | JTCTDW 31,497,1993 |
| oral/woman | lowest published toxic dose: 5670 µg/kg | Eye: Mydriasis (pupilliary dilation) Behavioral: Coma Lung, Thorax, or Respiration: Dyspnea | ANYAA9 160,383,1969 |
| oral/woman | lowest published toxic dose: 10 mL/kg | Cardiac: Arrythmias (indlucing changes in conduction) | JTCTDW 46,758,2008 |
| parenteral/frog | lethal dose (50 percent kill): 967 mg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Altered sleep time (including change in righting reflex) Lung, Thorax, or Respiration: Other changes | AIPTAK 124,212,1960 |
| skin/duck | lethal dose (50 percent kill): 28 mg/kg | TXAPA9 47,451,1979 | |
| skin/guinea pig | lethal dose (50 percent kill): 45 mg/kg | ENTOX* -,331,2005 | |
| skin/human | lowest published lethal dose: 7143 µg/kg | SKEZAP 9,1,1968 | |
| skin/mouse | lethal dose (50 percent kill): 19 mg/kg | ENTOX* -,331,2005 | |
| skin/rabbit | lethal dose (50 percent kill): 15 mg/kg | ENTOX* -,331,2005 | |
| skin/rat | lethal dose (50 percent kill): 6800 µg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement | TXAPA9 2,88,1960 |
| skin/wild bird | lethal dose (50 percent kill): 1800 µg/kg | TXAPA9 26,154,1973 | |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 10 mg/kg | Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 10 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| subcutaneous/guinea pig | lowest published toxic dose: 2.5 mg/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Kidney, Ureter, and Bladder: Urine volume decreased or anuria | TPKVAL 7,122,1965 |
| subcutaneous/mouse | lethal dose (50 percent kill): 10 mg/kg | PHARAT 37,729,1982 | |
| subcutaneous/rabbit | lethal dose (50 percent kill): 30 mg/kg | Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/rabbit | lethal dose (50 percent kill): 30 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| subcutaneous/rat | lethal dose (50 percent kill): 9 mg/kg | Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Respiratory stimulation Endocrine: Hyperglycemia | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 1.8 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 239,167,2007 |
| subcutaneous/rat | lowest published toxic dose: 18 mg/kg | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Fasciculations Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 219,106,2007 |
| subcutaneous/rat | lethal dose (50 percent kill): 9 mg/kg | Eye: Lacrimation Behavioral: Muscle contraction or spasticity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 6 mg/kg | Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 210,135,2005 |
| subcutaneous/rat | lowest published toxic dose: 0.63 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 25,599,2003 |
| subcutaneous/rat | lowest published toxic dose: 2.1 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 25,599,2003 |
| subcutaneous/rat | lowest published lethal dose: 12 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Changes in structure or function of salivary glands | ARTODN 76,650,2002 |
| Tank with water/Lugworm | lethal concentration (50 percent kill): 2.7 mg/L/48H | AQUTO* 10,235,1987 | |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 6 mg/kg | 30ZDA9 -,323,1971 | |
| unreported route/man | lowest published lethal dose: 1471 µg/kg | 85DCAI 2,73,1970 | |
| unreported route/mouse | lethal dose (50 percent kill): 14500 µg/kg | GTPZAB 7(5),38,1963 | |
| unreported route/rat | lowest published toxic dose: 1 mg/kg | Brain and Coverings: Other degenerative changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,309,2003 |
| unreported route/rat | lowest published toxic dose: 18 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 60,241,2001 |
| unreported route/rat | lowest published toxic dose: 18 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Other | TOXID9 60,241,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/Dog | lowest published toxic concentration: 200 µg/m3/7H/6W- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** AD-A041-973 |
| inhalation/rat | lowest published toxic concentration: 740 µg/m3/7H/6W- intermittent | Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** AD-A041-973 |
| intraperitoneal/mouse | lowest published toxic dose: 10 mg/kg/2D- intermittent | Behavioral: Sleep Behavioral: Change in motor activity (specific assay) | TOXID9 -,408,2009 |
| oral/chicken | lowest published toxic dose: 1800 µg/kg/18D- intermittent | Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 37,279,1987 |
| oral/Dog | lowest published toxic dose: 15 mg/kg/6W- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NTIS** AD-A041-973 |
| oral/Dog | lowest published toxic dose: 145 mg/kg/26W- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JJATDK 14,145,1994 |
| oral/Dog | lowest published toxic dose: 7.9 mg/kg/168D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/duck | lowest published toxic dose: 92500 µg/kg/5W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | RREVAH 81,1,1981 |
| oral/human | lowest published toxic dose: 4.2 mg/kg/42D- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/mammal (species unspecified) | lowest published toxic dose: 1394 mg/kg/30D- continuous | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** PB288-416 |
| oral/mouse | lowest published toxic dose: 5.6 mg/kg/14D- continuous | Brain and Coverings: Other degenerative changes | HBPTO* 2,1026,2001 |
| oral/pig | lowest published toxic dose: 196 mg/kg/49D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/rat | lowest published toxic dose: 901.6 mg/kg/112W- continuous | Endocrine: Adrenal cortex tumors | HBPTO* 1,814,2001 |
| oral/rat | lowest published toxic dose: 21.84 mg/kg/84D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | HBPTO* 1,59,2001 |
| oral/rat | lowest published toxic dose: 10500 mg/kg/28D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXAPA9 18,607,1971 |
| oral/rat | lowest published toxic dose: 788 mg/kg/15W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 2,523,1960 |
| oral/rat | lowest published toxic dose: 234 mg/kg/90D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | ENVRAL 17,1,1978 |
| oral/rat | lowest published toxic dose: 182 mg/kg/26W- continuous | Blood: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JPFCD2 16,1,1981 |
| subcutaneous/guinea pig | lowest published toxic dose: 420 mg/kg/24W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/mouse | lowest published toxic dose: 12 mg/kg/6D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 25,582,1973 |
| subcutaneous/rabbit | lowest published toxic dose: 225 mg/kg/30D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/rabbit | lowest published toxic dose: 1260 mg/kg/24W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 0.4 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | NETEEC 31,390,2009 |
| subcutaneous/rat | lowest published toxic dose: 0.4 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | NETEEC 31,390,2009 |
| subcutaneous/rat | lowest published toxic dose: 22.5 mg/kg/10D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 378 mg/kg/24W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 7,122,1965 |
| subcutaneous/rat | lowest published toxic dose: 32500 µg/kg/21D- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 73,33,1994 |
| unreported route/rat | lowest published toxic dose: 16 mg/kg/16D- intermittent | Brain and Coverings: Other degenerative changes Reproductive: Specific developmental abnormalities: Central nervous system | HBPTO* 2,1029,2001 |
| unreported route/rat | lowest published toxic dose: 0.4 mg/kg/4D- intermittent | Cardiac: Other changes Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 -,271,2008 |
| unreported route/rat | lowest published toxic dose: 0.8 mg/kg/4D- intermittent | Behavioral: Antianxiety | TOXID9 12,469,2008 |
| unreported route/rat | lowest published toxic dose: 0.4 mg/kg/4D- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport | TOXID9 -,286,2009 |
| unreported route/rat | lowest published toxic dose: 0.8 mg/kg/4D- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 -,286,2009 |
| unreported route/rat | lowest published toxic dose: 0.4 mg/kg/4D- intermittent | Behavioral: Alteration of operant conditioning | TOXID9 -,442,2009 |
| unreported route/rat | lowest published toxic dose: 0.04 mg/kg/4D- intermittent | Behavioral: Change in psychophysiological tests | NETEEC 31,242,2009 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.05 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 30,153,1983 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 30,153,1983 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMSUDL 7,56,1987 |
| TOXICOLOGY REVIEW | ANAEA3 35,165,1975 | |
| TOXICOLOGY REVIEW | AQMOAC #73-19,1973 | |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | MZUZA8 (8),90,1973 | |
| TOXICOLOGY REVIEW | CNDQA8 10(3),43,1975 | |
| TOXICOLOGY REVIEW | ECMAAI 14,141,1973 | |
| TOXICOLOGY REVIEW | DTTIAF 80,485,1973 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | CCATAR 366,1,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,588,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,331,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,306,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,308,2005 | |
| TOXICOLOGY REVIEW | JTEHD6 7,1,2004 | |
| TOXICOLOGY REVIEW | REPTED 23,260,2007 | |
| TOXICOLOGY REVIEW | FCTOD7 46,813,2008 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | TOLED5 190,107,2009 | |
| TOXICOLOGY REVIEW | TOLED5 190,107,2009 | |
| TOXICOLOGY REVIEW | REPTED 31,297,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 31,562,2010 | |
| TOXICOLOGY REVIEW | NRTXDN 33,575,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,118,1998 |
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.1 mg/m3 (skin) | DTLVS* 3,195,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.1 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 mg/m3, inhal, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.1 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.1 mg/m3, inhal, skin, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 0.1 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 mg/m3, skin, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.1 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.1 mg/m3;short term exposure limit 0.3 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.05 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0,05 mg/m3, JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.05 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THAILAND | time-weighted average 0.11 mg/m3, JAN1993 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.1 mg/m3, Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 0.1 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.1 mg/m3 | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.1 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PARATHION-air | 10H time-weighted average 0.05 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 | Hazard Code 53920; Number of Industries 1; Total Number of Facilities 43; Number of Occupations 4; Total Number of Employees Exposed 302 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9 | |
| EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal | |
| EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion | |
| EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (feed);clear evidence:rat | NCITR* NCI-TR-70,1979 |
| NCI Carcinogenesis Bioassay (feed);no evidence:mouse | NCITR* NCI-TR-70,1979 |
| NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600 | |
| On EPA IRIS database | |
| OSHA ANALYTICAL METHOD #ID-62 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division