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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-dimethyl ester, O,O-diester with 4,4'-thiodiphenol

RTECS #

TF6890000

CAS #

3383-96-8

Updated

September 201

Molecular Weight

466.48

Molecular Formula

C16H20O6P2S3

Synonyms

Abaphos
Abate
Abate (OSHA)
Abathion
AC 52160
American cyanamid AC 52,160
American cyanamid CL-52160
American cyanamid E.I. 52,160
Biothion
CL 52160
Difenthos
Difos
Ecopro 1707
EI 52160
ENT 27,165
Experimental insecticide 52160
Nephis 1G
O,O'-(Thiodi-4,1-phenylene)bis(O,O-dimethyl phosphorothioate)
O,O'-(Thiodi-p-phenylene) O,O,O',O'-tetramethyl bis(phosphorothioate)
O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene phosphorothioate
O,O-Dimethyl phosphorothioate O,O-diester with 4,4'-thiodiphenol
OMS 786
Phenol, 4,4'-thiodi-, O,O-diester with O,O-dimethyl phosphorothioate
Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester
Procida
Swebate
Temefos
Temephos
Temephos (ACGIH:OSHA)
Tetramethyl-O,O'-thiodi-p-phenylene phosphorothioate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H mildTXAPA9 21,369,1972

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
skin/rabbit 2132 mg/kg (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** AD-A134-545

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 683 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia		TOIZAG 16,297,1969
intraperitoneal/rat lethal dose (50 percent kill): 912 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands		TOIZAG 16,297,1969
oral/duck lethal dose (50 percent kill): 79 mg/kgTXAPA9 20,57,1971
oral/mammal (species unspecified) lethal dose (50 percent kill): 4700 mg/kgJAVMA4 152,282,1968
oral/mouse lethal dose (50 percent kill): 223 mg/kgARSIM* 20,1,1966
oral/pigeon lethal dose (50 percent kill): 50 mg/kgTXAPA9 20,57,1971
oral/quail lethal dose (50 percent kill): 75 mg/kgAECTCV 12,355,1983
oral/rabbit lethal dose (50 percent kill): 313 mg/kgVETNAL 60(11),63,1984
oral/rat lethal dose (50 percent kill): 1 gm/kgGUCHAZ 6,493,1973
oral/wild bird lethal dose (50 percent kill): 32 mg/kgTXAPA9 20,57,1971
skin/rabbit lethal dose (50 percent kill): 970 mg/kgAMCYC* 8/1966
skin/rat lethal dose (50 percent kill): 1370 mg/kgWRPCA2 9,119,1970
subcutaneous/chicken Lethal dose: >1 gm/kgBehavioral: Muscle weaknessAEHLAU 14,283,1967
subcutaneous/rat lethal dose (50 percent kill): 2302 mg/kgBehavioral: Somnolence (general depressed activity)TOIZAG 16,297,1969
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 4 gm/kg30ZDA9 -,338,1971
unreported route/rat lethal dose (50 percent kill): 8600 mg/kgTSPMA6 37(1),45,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/chicken lowest published toxic dose: 1668 mg/kg/16W- continuousBehavioral: Muscle weaknessAEHLAU 14,283,1967
oral/Dog lowest published toxic dose: 387 mg/kg/18W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		AEHLAU 14,283,1967
oral/rabbit lowest published toxic dose: 18483 mg/kg/44W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase		GISAAA 41(10),101,1976
oral/rat lowest published toxic dose: 14850 mg/kg/99D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AEHLAU 14,283,1967
oral/rat lowest published toxic dose: 18483 mg/kg/44W- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases		GISAAA 41(10),101,1976

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWRREVAH 46,1,1973

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,152,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3DTLVS* 3,1,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEMEPHOS, respirable fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEMEPHOS, total dust-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY

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