Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphoryl chloride

RTECS #

TH4897000

CAS #

10025-87-3

Updated

September 201

Molecular Weight

153.32

Molecular Formula

Cl₃OP

Synonyms

Fosforoxychlorid (Czech)
Oxychlorid fosforecny (Czech)
Phosphorus oxychloride
Phosphorus oxychloride (ACGIH)
Phosphorus oxytrichloride
Phosphoryl trichloride
Trichlorophosphine oxide
Trichlorophosphorus oxide

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lethal concentration (50 percent kill): 53 ppm/4H	Eye: Other eye effects Behavioral: Irritability Lung, Thorax, or Respiration: Dyspnea	AIHAAP 25,470,1964
inhalation/mammal (species unspecified)	lowest published toxic concentration: 0.48 mg/m³	Lung, Thorax, or Respiration: Cough	VCVN5* -,72,1993
inhalation/mouse	Lowest published lethal concentration: 48 mg/m³/36M		VCVN5* -,72,1993
inhalation/mouse	Lowest published lethal concentration: 5.7 mg/m³/4H		VCVN5* -,72,1993
inhalation/mouse	lethal concentration (50 percent kill): 404 mg/m³/2H		WDZAEK 6,98,1992
inhalation/rat	lethal concentration (50 percent kill): 32 ppm/4H		28ZPAK -,17,1972
inhalation/rat	Lowest published lethal concentration: 5.7 mg/m³/4H		VCVN5* -,72,1993
inhalation/rat	Lowest published lethal concentration: 48 mg/m³/36M		VCVN5* -,72,1993
inhalation/rat	lethal concentration (50 percent kill): 0.071 gm/m³		TPKVAL 13,107,1973
inhalation/rat	lowest published toxic concentration: 0.006 gm/m³	Lung, Thorax, or Respiration: Respiratory depression	TPKVAL 13,107,1973
inhalation/rat	lowest published toxic concentration: 0.001 gm/m³	Skin: After systemic exposure: Dermatitis, irritative	TPKVAL 13,107,1973
inhalation/rat	lowest published toxic concentration: 10 mg/m³/4H	Nutritional and Gross Metabolic: Changes in: Metabolic acidosis	TPKVAL 14,112,1975
inhalation/rat	Lowest published lethal concentration: 0.056 gm/m³	Eye: Lacrimation Eye: Corneal damage Behavioral: Somnolence (general depressed activity)	TPKVAL 13,107,1973
inhalation/rat	Lowest published lethal concentration: 0.089 gm/m³		TPKVAL 13,107,1973
ocular/rabbit	lowest published toxic dose: 100 pph	Behavioral: Excitement Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Respiratory depression	TPKVAL 13,107,1973
oral/mouse	lethal dose (50 percent kill): 327 mg/kg		WDZAEK 6,98,1992
oral/rat	lowest published lethal dose: 580 mg/kg		TPKVAL 13,107,1973
oral/rat	lethal dose (16 percent kill): 250 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Ulceration or bleeding from stomach Liver: Other changes	TPKVAL 13,107,1973
oral/rat	lethal dose (50 percent kill): 380 mg/kg		TPKVAL 13,107,1973
oral/rat	lethal dose (50 percent kill): 36 mg/kg	Gastrointestinal: Other changes Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0534840
skin/rabbit	lowest published lethal dose: 1 gm/kg	Behavioral: Muscle weakness Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0534840

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 1 mg/m³/122D- intermittent	Musculoskeletal: Osteoporosis	TPKVAL 14,112,1975
inhalation/mammal (species unspecified)	lowest published toxic concentration: 1340 µg/m³/17W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Musculoskeletal: Osteoporosis Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)	JHEMA2 21,387,1977
inhalation/rat	lowest published toxic concentration: 1 mg/m³/30D- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition	TPKVAL 14,112,1975
inhalation/rat	lowest published toxic concentration: 1 mg/m³/122D- intermittent	Musculoskeletal: Osteoporosis	TPKVAL 14,112,1975
inhalation/rat	lowest published toxic concentration: 1 mg/m³/91D- intermittent	Nutritional and Gross Metabolic: Changes in: Ca	TPKVAL 14,112,1975
inhalation/rat	lowest published toxic concentration: 4 mg/m³/50D- intermittent	Lung, Thorax, or Respiration: Other changes	WDZAEK 6,98,1992
oral/mouse	lowest published toxic dose: 480 mg/kg/60D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other changes	WDZAEK 6,98,1992
oral/rat	lowest published toxic dose: 480 mg/kg/60D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Other changes	WDZAEK 6,98,1992

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.63 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.2 ppm (1 mg/m³);KZW 0.8 ppm (4 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 ppm (0.64 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (0.6 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	short term exposure limit 0.5 ppm (2.4 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 ppm (0.6 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.2 ppm (1.3 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (0.6 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (0.6 mg/m³), short term exposure limit 0.5 ppm (3 mg/m³), 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.63 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0,1 ppm (0,63 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.05 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 0.1 ppm (0.6 mg/m³);short term exposure limit 0.2 ppm (1.2 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 0.1 ppm (0.6 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 0.6 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 0.5 ppm (3 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.2 ppm (1.3 mg/m³);short term exposure limit 0.6 ppm (3.8 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS OXYCHLORIDE-air	10H time-weighted average 0.1 ppm;short term exposure limit 0.5 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 81931; Number of Industries 9; Total Number of Facilities 165; Number of Occupations 29; Total Number of Employees Exposed 12587; Total Number of Female Employees Exposed 2945
National Occupational Hazard Survey 1974	Hazard Code 81931; Number of Industries 7; Total Number of Facilities 155; Number of Occupations 22; Total Number of Employees Exposed 7258

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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