Registry of Toxic Effects of Chemical Substances (RTECS)
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Polychlorinated biphenyl (aroclor 1242)
RTECS #
TQ1356000CAS #
53469-21-9; 11104-29-3Updated
December 2013Molecular Weight
N/RMolecular Formula
N/RSynonyms
Arochlor 1242Aroclor 1242
Chlorierte biphenyle, chlorgehalt 42% (German)
Chlorodiphenyl (42% chlorine)
Chlorodiphenyl (42% chlorine) (ACGIH,OSHA)
Chlorodiphenyl (42% Cl)
Clophen 42
Clorodifenili, cloro 42% (Italian)
Diphenyle chlore, 42% de chlore (French)
Gechloreerdedifenyl (Dutch)
PCB (OSHA)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| other mutation test systems | other cell types/mouse | 25 ppm/4H | EESADV 3,10,1979 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/rat | 945 mg/kg (36W prior to copulation) | Reproductive: Other effects on female Endocrine: Estrogenic | AECTCV 3,479,1975/1976 |
| oral/rat | 1890 mg/kg (36W prior to copulation) | Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | AECTCV 3,479,1975/1976 |
| oral/rat | 1250 mg/kg (5D male) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | FCTXAV 13,507,1975 |
| oral/pig | 93 mg/kg (1-16W pregnant) | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | AJVRAH 36,23,1975 |
| oral/mammal (species unspecified) | 188 mg/kg (17W pre-28D after birth) | Reproductive: Effects on fertility: Other measures of fertility | AECTCV 9,627,1980 |
| oral/mouse | 3300 mg/kg (14D pre-21D after birth) | Reproductive: Effects on newborn: Stillbirth Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | REPTED 15,281,2001 |
| oral/mouse | 825 mg/kg (14D pre-21D after birth) | Reproductive: Specific developmental abnormalities: Urogenital system | REPTED 15,281,2001 |
| subcutaneous/mouse | 300 mg/kg (14D prior to copulation) | Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | AECTCV 44,72,2003 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 10 mg/m3 | Lung, Thorax, or Respiration: Other changes Liver: Other changes | 85CYAB 2,153,1959 |
| intraperitoneal/mammal (species unspecified) | lethal dose (50 percent kill): >1 gm/kg | AECTCV 6,279,1977 | |
| intraperitoneal/rat | lowest published toxic dose: 160 mg/kg | Reproductive: Maternal effects: Uterus, cervix, vagina | RCOCB8 9,85,1974 |
| oral/mammal (species unspecified) | lethal dose (50 percent kill): >3 gm/kg | AECTCV 6,279,1977 | |
| oral/rat | lowest published lethal dose: 2500 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | BECTA6 13,14,1975 |
| oral/rat | lowest published toxic dose: 5000 mg/kg | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | BECTA6 13,14,1975 |
| oral/rat | lethal dose (50 percent kill): 4250 mg/kg | Eye: Chromodacryorrhea Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 24,434,1973 |
| skin/rabbit | lowest published lethal dose: 1269 mg/kg | ARVPAX 14,139,1974 | |
| subcutaneous/guinea pig | lowest published lethal dose: 345 mg/kg | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen | PHRPA6 59,1085,1944 |
| subcutaneous/rat | lowest published toxic dose: 190 mg/kg | Endocrine: Estrogenic | JAFCAU 18,1108,1970 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intramuscular/domestic animal | lowest published toxic dose: 5 mg/kg/20D- intermittent | Liver: Other changes | JEPOEC 12,17,1993 |
| intramuscular/rabbit | lowest published toxic dose: 25 mg/kg/20D- intermittent | Liver: Other changes | JEPOEC 12,17,1993 |
| intraperitoneal/rat | lowest published toxic dose: 400 mg/kg/2D- intermittent | Endocrine: Evidence of thyroid hypofunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data: Changes in uterine weight | BECTA6 53,583,1994 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/5D- intermittent | Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | EVHPAZ 102,568,1994 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/2D- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | EVHPAZ 102,568,1994 |
| intraperitoneal/rat | lowest published toxic dose: 175 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | TXAPA9 48,185,1979 |
| intraperitoneal/rat | lowest published toxic dose: 1600 mg/kg/10W- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in erythrocyte (RBC) count | TXAPA9 28,189,1974 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/2D- intermittent | Related to Chronic Data: Changes in uterine weight | EVHPAZ 102,568,1994 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/3D- intermittent | Related to Chronic Data: Changes in uterine weight | EVHPAZ 102,568,1994 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/5D- intermittent | Related to Chronic Data: Changes in uterine weight | EVHPAZ 102,568,1994 |
| intraperitoneal/rat | lowest published toxic dose: 48 mg/kg/2D- intermittent | Endocrine: Evidence of thyroid hypofunction | JTEHD6 51,503,1997 |
| intraperitoneal/rat | lowest published toxic dose: 72 mg/kg/3D- intermittent | Endocrine: Evidence of thyroid hypofunction | JTEHD6 51,503,1997 |
| intraperitoneal/rat | lowest published toxic dose: 120 mg/kg/5D- intermittent | Endocrine: Evidence of thyroid hypofunction | JTEHD6 51,503,1997 |
| oral/monkey | lowest published toxic dose: 75600 µg/kg/27W- continuous | Gastrointestinal: Other changes Blood: Changes in cell count (unspecified) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | LAINAW 40,373,1979 |
| oral/mouse | lowest published toxic dose: 825 mg/kg/66D- intermittent | Endocrine: Changes in thymus weight | REPTED 15,281,2001 |
| oral/mouse | lowest published toxic dose: 1650 mg/kg/66D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | REPTED 15,281,2001 |
| oral/mouse | lowest published toxic dose: 75600 µg/kg/18W- continuous | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | EVHPAZ 39,79,1981 |
| oral/mouse | lowest published toxic dose: 842 mg/kg/6W- continuous | Immunological Including Allergic: Decrease in humoral immune response | DCTODJ 2,111,1979 |
| oral/quail | lowest published toxic dose: 12200 mg/kg/61D- continuous | Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Conditioned vitamin deficiency | BECTA6 9,179,1973 |
| oral/rabbit | lowest published toxic dose: 4200 mg/kg/14W- intermittent | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | AJPAA4 70,363,1973 |
| oral/rat | lowest published toxic dose: 224 mg/kg/7D- intermittent | Endocrine: Other changes | TOXID9 60,380,2001 |
| oral/rat | lowest published toxic dose: 455 mg/kg/13W- continuous | Behavioral: Change in motor activity (specific assay) | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 1890 mg/kg/36W- continuous | Liver: Hepatitis (hepatocellular necrosis), zonal | AECTCV 10,171,1981 |
| oral/rat | lowest published toxic dose: 366 mg/kg/61D- continuous | Liver: Other changes Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Lipids including transport | BECTA6 9,179,1973 |
| oral/rat | lowest published toxic dose: 2100 mg/kg/21D- intermittent | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | BECTA6 13,456,1975 |
| oral/rat | lowest published toxic dose: 5460 mg/kg/26W- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | TXAPA9 32,461,1975 |
| oral/rat | lowest published toxic dose: 2790 mg/kg/372D- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 967.2 mg/kg/372D- continuous | Behavioral: Change in motor activity (specific assay) | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 682.5 mg/kg/91D- continuous | Behavioral: Change in motor activity (specific assay) | TOSCF2 53,377,2000 |
| oral/rat | lowest published toxic dose: 2000 mg/kg/4D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | BECTA6 13,14,1975 |
| subcutaneous/domestic animal | lowest published toxic dose: 20 mg/kg/20D- intermittent | Immunological Including Allergic: Decrease in humoral immune response Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JEPOEC 9,283,1989 |
| subcutaneous/rabbit | lowest published toxic dose: 25 mg/kg/20D- intermittent | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Biochemical: Metabolism (intermediary): Other proteins | JEPOEC 9,283,1989 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Limited Evidence | IMEMDT 18,43,1978 |
| TOXICOLOGY REVIEW | EVHPAZ 1,105,1972 | |
| TOXICOLOGY REVIEW | ARVPAX 14,139,1974 | |
| TOXICOLOGY REVIEW | RREVAH 44,1,1973 | |
| TOXICOLOGY REVIEW | STEVA8 2,305,1974 | |
| TOXICOLOGY REVIEW | BISNAS 20,958,1970 | |
| TOXICOLOGY REVIEW | ENVRAL 5,249,1972 | |
| TOXICOLOGY REVIEW | TIHEEC 16,305,2000 | |
| TOXICOLOGY REVIEW | ITODC* -,327,2004 | |
| TOXICOLOGY REVIEW | NRTXDN 33,178,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1 mg/m3 (skin) | DTLVS* 3,51,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Carcinogen, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.1 ppm (1 mg/m3);KZW 1 ppm (10 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 mg/m3, Skin, MAR2002 | |
| Occupational Exposure Limit-FRANCE | VME 1 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 0.1 ppm (1.1 mg/m3), 2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.1 ppm (1 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.01 mg/m3;short term exposure limit 0.03 mg/m3, Carcinogen, Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.1 ppm (1 mg/m3), KZG-week 0.8 ppm (8 mg/m3), carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1 mg/m3, Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO POLYCHLORINATED BIPHENYLS-air | 10H Carcinogen time-weighted average 0.001 mg/m3 | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X1183; Number of Industries 3; Total Number of Facilities 58; Number of Occupations 5; Total Number of Employees Exposed 2214; Total Number of Female Employees Exposed 285 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division