Registry of Toxic Effects of Chemical Substances (RTECS)
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Propane, 1-chloro-2,3-epoxy-
RTECS #
TX4900000CAS #
106-89-8Updated
September 201Molecular Weight
92.53Molecular Formula
C3H5ClOSynonyms
(Chloromethyl)ethylene oxide(DL)-alpha-Epichlorohydrin
1,2-Epoxy-3-chloropropane
1-Chloor-2,3-epoxy-propaan (Dutch)
1-Chlor-2,3-epoxy-propan (German)
1-Chloro-2,3-epoxypropane
1-Chloro-2,3-epoxypropane (OSHA)
1-Cloro-2,3-epossipropano (Italian)
2-(Chloromethyl)oxirane
2,3-Epoxypropyl chloride
3-Chloro-1,2-epoxypropane
3-Chloro-1,2-propane oxide
3-Chloro-1,2-propylene oxide
alpha-Epichlorohydrin
Chloromethyloxirane
Chloropropylene oxide
ECH
Epichloorhydrine (Dutch)
Epichlorhydrin
Epichlorhydrine (French)
Epichlorohydrin
epi-Chlorohydrin
Epichlorohydrin (ACGIH:OSHA)
Epichlorohydryna (Polish)
Epichlorophydrin
Epicloridrina (Italian)
gamma-Chloropropylene oxide
Glycerol epichlorhydrin
Oxirane, (chloromethyl)-
Oxirane, 2-(chloromethyl)
RCRA waste number U041
Skekhg
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 100 mg | severe | AJOPAA 29,1363,1946 |
| eye /rabbit | 100 mg/24H | moderate | 85JCAE -,769,1986 |
| skin /rabbit | 10 mg/24H open irritation test | JIHTAB 30,63,1948 | |
| skin /woman | 1% | CODEDG 61,47,2009 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/human | 10 µmol/L/24H | STEVA8 11,223,1979 |
| Cytogenetic Analysis | leukocyte/human | 1 µmol/L | MUREAV 34,279,1976 |
| Cytogenetic Analysis | liver/rat | 10 mg/L | MUREAV 64,329,1979 |
| Cytogenetic Analysis | intraperitoneal/mouse | 5 mg/kg | STEVA8 11,223,1979 |
| Cytogenetic Analysis | oral/mouse | 20 mg/kg | STEVA8 11,223,1979 |
| Cytogenetic Analysis | inhalation/mouse | 5 mg/m3 | MUREAV 85,287,1981 |
| Cytogenetic Analysis | ovary/hamster | 15 mg/L | MUTAEX 4,432,1989 |
| Cytogenetic Analysis | lung/hamster | 47 mg/L | GMCRDC 27,95,1981 |
| DNA Damage | mammary gland/human | 2.8 mg/L/24H (-enzymatic activation step) | MUREAV 588,47,2005 |
| DNA Damage | liver/rat | 200 µmol/L/3H | MUREAV 629,49,2007 |
| DNA Damage | lymphocyte/mouse | 1040 µmol/L | MUREAV 203,155,1988 |
| DNA Damage | intraperitoneal/mouse | 140 mg/kg | MUREAV 467,83,2000 |
| DNA Damage | liver/rat | 300 µmol/L | SinJF# 26OCT1982 |
| DNA Damage | /Escherichia coli | 1 µmol/L | ARTODN 46,277,1980 |
| DNA Damage | /Bacillus subtilis | 20 µL/disc | PMRSDJ 1,175,1981 |
| DNA inhibition | HeLa cell/human | 2700 µmol/L | MUREAV 92,427,1982 |
| DNA inhibition | lymphocyte/human | 5 mmol/L | TUMOAB 69,191,1983 |
| DNA repair | /Escherichia coli | 4 µg/well | MUREAV 133,161,1984 |
| DNA repair | /Bacillus subtilis | 997 mmol/L | 37ATAD -,155,1977 |
| DNA repair | /Saccharomyes cerevisiae | 100 mg/L | PMRSDJ 1,502,1981 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 65 mmol/L | IJEBA6 18,1337,1980 |
| host-mediated assay | Salmonella typhimurium/mouse | 50 mg/kg | BIZNAT 95,451,1976 |
| host-mediated assay | Escherichia coli/mouse | 180 mg/kg | MUREAV 272,161,1992 |
| micronucleus test | intraperitoneal/mouse | 120 mg/kg/16D- intermittent | 54DEAI -,175,1984 |
| micronucleus test | multiple/non-mammalian species | 10800 nmol/L | MUTAEX 4,17,1989 |
| morphological transform | kidney/hamster | 25 mg/L | PMRSDJ 1,638,1981 |
| morphological transform | embryo/mouse | 30 mg/L/10D | MUREAV 702,100,2010 |
| mutation in mammalian somatic cells | ovary/hamster | 30 mg/L | MUREAV 136,137,1984 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 7500 µg/L | PMRSDJ 1,580,1981 |
| mutation in mammalian somatic cells | other cell types/human | 500 µmol/L | TUMOAB 69,191,1983 |
| mutation in microorganisms | /Schizosaccharomyces pombe | 21 mmol/L (-enzymatic activation step) | ADWMAX -,193,1962 |
| mutation in microorganisms | /Schizosaccharomyces pombe | 800 µmol/L (+enzymatic activation step) | MUREAV 109,41,1983 |
| mutation in microorganisms | /Neurospora crassa | 150 mmol/L (-enzymatic activation step) | STEVA8 11,223,1979 |
| mutation in microorganisms | /Saccharomyes cerevisiae | 40 mg/L (-enzymatic activation step) | PMRSDJ 1,414,1981 |
| mutation in microorganisms | /Klebsiella pneumoniae | 200 µmol/L (-enzymatic activation step) | MUREAV 89,269,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 33 µg/plate (+enzymatic activation step) | MUREAV 172,105,1986 |
| mutation in microorganisms | /Escherichia coli | 1 µL/plate (+/-enzymatic activation step) | PMRSDJ 1,387,1981 |
| mutation in microorganisms | /Salmonella typhimurium | 1 µL/plate (-enzymatic activation step) | FCTOD7 46,2498,2008 |
| other mutation test systems | /Escherichia coli | 195 nmol/tube | MUREAV 147,79,1985 |
| other mutation test systems | /Salmonella typhimurium | 60 mg/L | MUREAV 192,239,1987 |
| other mutation test systems | /Bacillus subtilis | 1 mole/L | 37ATAD -,155,1977 |
| sex chromosome loss and nondisjunction | parenteral/Drosophila melanogaster | 5100 µmol/L | EVSRBT 24,175,1981 |
| sex chromosome loss and nondisjunction | /Saccharomyes cerevisiae | 100 mg/L | PMRSDJ 1,468,1981 |
| sister chromatid exchange | lymphocyte/human | 10 nmol/L | CARYAB 34,261,1981 |
| sister chromatid exchange | intraperitoneal/mouse | 5500 µg/kg | PMRSDJ 1,673,1981 |
| sister chromatid exchange | ovary/hamster | 33 µL/L | PMRSDJ 1,551,1981 |
| sister chromatid exchange | lung/hamster | 100 mg/L | CNREA8 44,3270,1984 |
| sperm morphology | inhalation/mouse | 5 mg/m3 | MUREAV 85,287,1981 |
| sperm morphology | oral/rat | 50 mg/kg | ARTODN 53,71,1983 |
| Unscheduled DNA Synthesis | oral/rat | 50 mg/kg | CRNGDP 10,1425,1989 |
| Unscheduled DNA Synthesis | fibroblast/human | 32 µg/L | PMRSDJ 1,528,1981 |
| Unscheduled DNA Synthesis | lymphocyte/human | 500 µmol/L | TUMOAB 69,191,1983 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 50 ppm/6H (50D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TXAPA9 68,415,1983 |
| inhalation/rat | 100 ppm/7H (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | NTIS** OTS0545225 |
| inhalation/rabbit | 100 ppm/7H (6-18D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | NTIS** OTS0545225 |
| oral/mouse | 1200 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JTEHD6 9,87,1982 |
| oral/rat | 180 mg/kg (12D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | NATUAS 226,87,1970 |
| oral/rat | 25 mg/kg (1D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | ARTODN 53,71,1983 |
| oral/rat | 1050 mg/kg (21D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | FAATDF 13,16,1989 |
| oral/rat | 288 mg/kg (23D male) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) | JOAND3 12,54,1991 |
| subcutaneous/rat | 75 mg/kg (1D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct | TXAPA9 70,67,1983 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 100 ppm/6H/30D- continuous | Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Acute pulmonary edema | JJIND8 65,751,1980 |
| inhalation/rat | toxic concentration (other than lowest): 100 ppm/6H/6W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | PAACA3 21,106,1980 |
| inhalation/rat | toxic concentration (other than lowest): 100 ppm | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors | CHWKA9 123(24),25,1978 |
| inhalation/rat | toxic concentration (other than lowest): 30 ppm/6H/57W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | JJIND8 65,751,1980 |
| intraperitoneal/mouse | lowest published toxic dose: 2400 mg/kg/8W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors | TXAPA9 82,19,1986 |
| oral/rat | toxic dose: 36 gm/kg/81W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | GANNA2 71,922,1980 |
| oral/rat | toxic dose: 85050 mg/kg/81W- continuous | Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors | NAIZAM 32,270,1981 |
| oral/rat | toxic dose: 42525 mg/kg/81W- continuous | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NAIZAM 32,270,1981 |
| oral/rat | toxic dose: 5150 mg/kg/2Y- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors Endocrine: Tumors | TXCYAC 36,325,1985 |
| oral/rat | lowest published toxic dose: 60 gm/kg/81W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | GANNA2 71,922,1980 |
| subcutaneous/mouse | toxic dose: 2760 mg/kg/69W- intermittent | Tumorigenic: Neoplastic by RTECS criteria Tumorigenic: Tumors at site of application | JNCIAM 53,695,1974 |
| subcutaneous/mouse | lowest published toxic dose: 720 mg/kg/18W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application | JNCIAM 48,1431,1972 |
| unreported route/mouse | lowest published toxic dose: 19 mg/kg | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease Skin and Appendages: Tumors | RARSAM 3,193,1963 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/human | lowest published toxic concentration: 40 ppm/2H | Lung, Thorax, or Respiration: Other changes | 34ZIAG -,240,1969 |
| inhalation/human | lowest published toxic concentration: 20 ppm | Olfaction: Other olfaction effects Eye: Other eye effects | 29ZWAE -,108,1968 |
| inhalation/mammal (species unspecified) | lowest published toxic concentration: 1 gm/m3 | Lung, Thorax, or Respiration: Respiratory depression | TPKVAL 7,76,1965 |
| inhalation/mouse | lethal concentration (50 percent kill): 3 gm/m3/2H | Gastrointestinal: Necrotic changes Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 2,28,1961 |
| inhalation/mouse | Lowest published lethal concentration: 5.25 gm/m3/2H | Skin: After systemic exposure: Dermatitis, other | TPKVAL 2,28,1961 |
| inhalation/mouse | Lowest published lethal concentration: 3.25 gm/m3/2H | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Lung, Thorax, or Respiration: Dyspnea | TPKVAL 2,28,1961 |
| inhalation/mouse | Lowest published lethal concentration: 72 gm/m3/9M | JBMRBG 8,11,1974 | |
| inhalation/rat | lethal concentration (50 percent kill): 250 ppm/8H | ENTOX* -,228,2005 | |
| inhalation/rat | lethal concentration (50 percent kill): 3 gm/m3/2H | Brain and Coverings: Changes in circulation Behavioral: Ataxia Cardiac: Cardiomyopathy including infarction | TPKVAL 2,28,1961 |
| inhalation/rat | Lowest published lethal concentration: 3.25 gm/m3/2H | Eye: Miosis (pupilliary constriction) Eye: Lacrimation Eye: Corneal damage | TPKVAL 2,28,1961 |
| inhalation/rat | Lowest published lethal concentration: 3 gm/m3 | Brain and Coverings: Changes in circulation Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance Gastrointestinal: Necrotic changes | TPKVAL 7,76,1965 |
| inhalation/rat | Lowest published lethal concentration: 3 gm/m3 | Liver: Fatty liver degeneration Liver: Other changes Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney | TPKVAL 7,76,1965 |
| inhalation/rat | lowest published toxic concentration: 0.007 gm/m3/4H | Lung, Thorax, or Respiration: Respiratory depression Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight | TPKVAL 12,33,1971 |
| inhalation/rat | lowest published toxic concentration: 0.35 gm/m3/4H | Cardiac: Change in rate Vascular: BP lowering not characterized in autonomic section | TPKVAL 12,33,1971 |
| intraperitoneal/guinea pig | lethal dose (50 percent kill): 118 mg/kg | JPMSAE 61,1712,1972 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 170 mg/kg | JPMSAE 61,1712,1972 | |
| intraperitoneal/rabbit | lethal dose (50 percent kill): 160 mg/kg | JPMSAE 61,1712,1972 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 113 mg/kg | JPMSAE 61,1712,1972 | |
| intravenous/rat | lethal dose (50 percent kill): 154 mg/kg | NPIRI* 1,41,1974 | |
| ocular/mammal (species unspecified) | lowest published toxic dose: 100 pph | Eye: Conjunctiva irritation | TPKVAL 7,76,1965 |
| ocular/rabbit | lowest published toxic dose: 100 pph | Eye: Conjunctiva irritation Eye: Corneal damage | TPKVAL 2,28,1961 |
| oral/guinea pig | lethal dose (50 percent kill): 280 mg/kg | GISAAA 33(1),46,1968 | |
| oral/mammal (species unspecified) | lowest published toxic dose: 350 mg/kg | TPKVAL 7,76,1965 | |
| oral/mouse | lethal dose (50 percent kill): 236 mg/kg | ENTOX* -,228,2005 | |
| oral/mouse | lethal dose (50 percent kill): 195 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Behavioral: Ataxia | GISAAA 33(1),46,1968 |
| oral/rabbit | lethal dose (50 percent kill): 345 mg/kg | GISAAA 33(1),46,1968 | |
| oral/rat | lethal dose (50 percent kill): 90 mg/kg | ENTOX* -,228,2005 | |
| skin/mouse | lethal dose (50 percent kill): 250 mg/kg | 85GMAT -,64,1982 | |
| skin/rabbit | lethal dose (50 percent kill): 515 mg/kg | WolMA# 18JAN1977 | |
| skin/rat | lowest published lethal dose: 1 gm/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | UCPHAQ 2,69,1941 |
| subcutaneous/mouse | lowest published lethal dose: 250 mg/kg | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Dyspnea Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | TPKVAL 2,28,1961 |
| subcutaneous/mouse | lethal dose (70 percent kill): 250 mg/kg | Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli | TPKVAL 2,28,1961 |
| subcutaneous/rat | lethal dose (50 percent kill): 150 mg/kg | Kidney, Ureter, and Bladder: Urine volume increased | AMPMAR 28,505,1967 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 25 ppm/6H/90D- intermittent | Olfaction: Ulcerated nasal septum Olfaction: Other olfaction effects Liver: Other changes | NTIS** OTS0555021 |
| inhalation/mouse | lowest published toxic concentration: 1 gm/m3/2W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 0.21 gm/m3/45D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in spleen Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 0.21 gm/m3/30D- intermittent | Behavioral: Somnolence (general depressed activity) Vascular: Other changes Lung, Thorax, or Respiration: Dyspnea | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 0.04 gm/m3/182D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 0.04 gm/m3/61D- intermittent | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Vascular: BP elevation not characterized in autonomic section | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 0.04 gm/m3/91D- intermittent | Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 0.04 gm/m3/197D- intermittent | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Liver: Other changes Kidney, Ureter, and Bladder: Other changes | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 170 mg/m3/3H/17W- continuous | Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 1 gm/m3/2W- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 2,28,1961 |
| inhalation/rat | lowest published toxic concentration: 20 mg/m3/24H/14W- continuous | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Blood: Other changes | GISAAA 31(9),7,1966 |
| inhalation/rat | lowest published toxic concentration: 5 ppm/2H/5W- intermittent | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | HOCHE8 12,144,1994 |
| intraperitoneal/mouse | lowest published toxic dose: 120 mg/kg/16D- intermittent | Blood: Normocytic anemia Blood: Microcytosis with or without anemia | NTIS** OTS0542017 |
| intraperitoneal/rat | lowest published toxic dose: 341 µg/kg/30D- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPMSAE 61,1712,1972 |
| intraperitoneal/rat | lowest published toxic dose: 2045 µg/kg/12W- intermittent | Brain and Coverings: Changes in brain weight Behavioral: Food intake (animal) Blood: Changes in other cell count (unspecified) | JPMSAE 61,1712,1972 |
| intraperitoneal/wild bird | lowest published toxic dose: 60 mg/kg/3D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | IJEBA6 37,774,1999 |
| oral/rabbit | lowest published toxic dose: 4872 mg/kg/9W- intermittent | Endocrine: Changes in spleen weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Other proteins | GISAAA 33(1),46,1968 |
| oral/rabbit | lowest published toxic dose: 91 mg/kg/9W- intermittent | Liver: Liver function tests impaired Blood: Changes in other cell count (unspecified) Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | GISAAA 33(1),46,1968 |
| oral/rat | lowest published toxic dose: 190 mg/kg/10D- intermittent | Gastrointestinal: Alteration in gastric secretion Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 19,41,1996 |
| oral/rat | lowest published toxic dose: 1218 mg/kg/9W- intermittent | Liver: Changes in liver weight Endocrine: Changes in adrenal weight Biochemical: Metabolism (intermediary): Other proteins | GISAAA 33(1),46,1968 |
| oral/rat | lowest published toxic dose: 910 mg/kg/26W- intermittent | Behavioral: Alteration of classical conditioning | GISAAA 33(1),46,1968 |
| subcutaneous/rat | lowest published toxic dose: 270 mg/kg/9D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes | WDZAEK 6,270,1992 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 11,131,1976 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,603,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMSUDL 7,202,1987 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,603,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2A | IMEMDT 71,603,1999 |
| TOXICOLOGY REVIEW | MUREAV 566,21,2004 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 567,227,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,109,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,151,2004 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | FCTOD7 44,1699,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,228,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | MUREAV 654,114,2008 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | TXAPA9 243,180,2010 | |
| TOXICOLOGY REVIEW | MUREAV 678,76,2009 | |
| TOXICOLOGY REVIEW | MUREAV 751,49,2012 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (19 mg/m3) (skin) | DTLVS* 3,98,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 2 ppm (10 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 2 ppm (7.6 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | TRK-TMW 3 ppm (12 mg/m3);KZW 12 ppm (48 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 ppm (2 mg/m3), Skin, Carcinogen, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.5 ppm (1.9 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.5 ppm (1.9 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 2 ppm (10 mg/m3), C2 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | ceiling concentration 1.9 mg/m3, Skin, Carcinogen, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.5 ppm (1.9 mg/m3), carc, skin, sen, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2A carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 2 ppm (10 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 2 ppm (10 mg/m3);short term exposure limit 5 ppm (20 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 ppm (1.9 mg/m3); short term exposure limit 1.5 ppm (5.8 mg/m3), skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.5 ppm (1.9 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.5 ppm (1.9 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, short term exposure limit 8 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 0.5 ppm (1.9 mg/m3);short term exposure limit 1 ppm (4 mg/m3), Skin, Carcinogen, Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 2 ppm (8 mg/m3), carc 2, skin, sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 1.9 mg/m3, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 ppm (19 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 ppm (19 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 ppm (1.9 mg/m3);short term exposure limit 1.5 ppm (5.8 mg/m3), carc, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (19 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (19 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (19 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (19 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EPICHLOROHYDRIN-air | Carcinogen lowest feasible concentration | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 29010; Number of Industries 75; Total Number of Facilities 4249; Number of Occupations 87; Total Number of Employees Exposed 80170; Total Number of Female Employees Exposed 14921 | |
| National Occupational Hazard Survey 1974 | Hazard Code 29010; Number of Industries 40; Total Number of Facilities 2004; Number of Occupations 58; Total Number of Employees Exposed 41380 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus | |
| EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-human; Sperm morphology-mouse | |
| EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat | |
| EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; S pombe-forward mutation | |
| EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test | |
| EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human lymphocyte | |
| EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte | |
| EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N crassa-reversion | |
| EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion | |
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NIOSH Analytical Method, 1994: Epichlorohydrin, 1010 | |
| NIOSH CURRENT INTELLIGENCE BULLETIN 30, 1978 | |
| NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen | |
| On EPA IRIS database |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division