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Registry of Toxic Effects of Chemical Substances (RTECS)

Propanedial

RTECS #

TX6475000

CAS #

542-78-9

Updated

December 2013

Molecular Weight

72.07

Molecular Formula

C3H4O2

Synonyms

1,3-Propanedial
1,3-Propanedialdehyde
1,3-Propanedione
Malonaldehyde
Malondialdehyde
Malonic aldehyde
Malonic dialdehyde
Malonodialdehyde
Malonyldialdehyde
NCI-C54842

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli20 mmol/LMUREAV 88,23,1981
DNA adductlymphocyte/mammal (species unspecified)250 mg/L/5HEJBCAI 5,178,1968
DNA adductintraperitoneal/mouse3000 nmol/L/1W- intermittentCALEDQ 185,13,2002
DNA Damageleukocyte/human1 mmol/LCLREAS 23(5),595A,1975
DNA Damagefibroblast/human10 µmol/LCLREAS 23(5),595A,1975
DNA inhibitionfibroblast/human25 mg/LEJBCAI 5,178,1968
DNA inhibitionfibroblast/rat1 mmol/LJTEHD6 6,811,1980
DNA repair/Escherichia coli20 mmol/LMUREAV 88,23,1981
morphological transformfibroblast/rat1 mmol/LJTEHD6 6,811,1980
mutation in mammalian somatic cellslymphocyte/mouse10 µmol/LMAGDA3 11,137,1979
mutation in microorganisms/Salmonella typhimurium13850 nmol/plate (+enzymatic activation step)BTERDG 2,81,1980
mutation in microorganisms/Salmonella typhimurium1 nmol/plate (-enzymatic activation step)MUREAV 78,113,1980
mutation in microorganisms/Escherichia coli2 mmol/L (-enzymatic activation step)MUREAV 88,23,1981
other mutation test systemsfibroblast/rat100 µmol/LJTEHD6 6,811,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 7488 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease		AUODDK 55,3,1980
skin/mouse toxic dose: 30 gm/kg/9W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application		JNCIAM 53,1771,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 606 mg/kgAUODDK 55,3,1980
oral/rat lethal dose (50 percent kill): 632 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		TXAPA9 7,826,1965

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 45000 mg/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainVCVGK* -,403,1994
oral/mouse lowest published toxic dose: 22500 mg/kg/90D- continuousGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder		VCVGK* -,403,1994
oral/rat lowest published toxic dose: 36.5 mg/kg/1Y- continuousLiver: Tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVGK* -,403,1994

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1037,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 36,163,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 36,163,1985
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1037,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1037,1999
TOXICOLOGY REVIEWTOLED5 134,51,2002
TOXICOLOGY REVIEWMUREAV 544,115,2003
TOXICOLOGY REVIEWMUREAV 531,1,2003
TOXICOLOGY REVIEWMUREAV 531,219,2003
TOXICOLOGY REVIEWMUTAEX 19,169,2004
TOXICOLOGY REVIEWMUREAV 659,56,2008
TOXICOLOGY REVIEWMUREAV 659,68,2008
TOXICOLOGY REVIEWMUREAV 659,15,2008
TOXICOLOGY REVIEWMUREAV 574,92,2005
TOXICOLOGY REVIEWMUREAV 681,93,2009
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWMUREAV 674,62,2009
TOXICOLOGY REVIEWMUREAV 674,85,2009
TOXICOLOGY REVIEWMUREAV 681,68,2009
TOXICOLOGY REVIEWMUTAEX 21,225,2006
TOXICOLOGY REVIEWMUREAV 690,3,2010
TOXICOLOGY REVIEWMUREAV 711,13,2011
TOXICOLOGY REVIEWMUREAV 726,91,2011
TOXICOLOGY REVIEWMUREAV 722,147,2011
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWMUREAV 750,141,2012
TOXICOLOGY REVIEWREPTED 35,165,2013
TOXICOLOGY REVIEWMUREAV 733,4,2012
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWMUREAV 752,153,2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALONALDEHYDE-airCarcinogen lowest feasible concentrationNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991

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