Registry of Toxic Effects of Chemical Substances (RTECS)
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Propanenitrile, 2-methyl-
RTECS #
TZ4900000CAS #
78-82-0Updated
August 2009Molecular Weight
69.12Molecular Formula
C4H7NSynonyms
2-Cyanopropane2-Methylpropanenitrile
2-Methylpropionitrile
alpha-Methylpropanenitrile
Dimethylacetonitrile
Isopropyl cyanide
Isopropyl nitrile
Isopropylkyanid (Czech)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 380 mg open irritation test | mild | UCDS** 10/29/1959 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | Lowest published lethal concentration: 1000 ppm/4H | AIHAAP 23,95,1962 | |
| inhalation/rat | lethal concentration (10 percent kill): 1173 ppm/1H | Lung, Thorax, or Respiration: Acute pulmonary edema Lung, Thorax, or Respiration: Dyspnea | HPV108 -,-,2003 |
| inhalation/rat | lethal concentration (50 percent kill): >1000 ppm/1H | HPV108 -,-,2003 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 25 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Excitement Lung, Thorax, or Respiration: Dyspnea | ZAARAM 19,225,1969 |
| oral/mouse | lethal dose (50 percent kill): 25 mg/kg | ARTODN 55,47,1984 | |
| oral/rabbit | lethal dose (50 percent kill): 14 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | ZAARAM 19,225,1969 |
| oral/rat | lethal dose (50 percent kill): 77 mg/kg | HPV108 -,-,2003 | |
| oral/rat | lethal dose (50 percent kill): 50 mg/kg | Behavioral: Somnolence (general depressed activity) Vascular: Regional or general arteriolar or venous dilation Lung, Thorax, or Respiration: Respiratory depression | HPV108 -,-,2003 |
| oral/rat | lethal dose (50 percent kill): 50 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness Vascular: Regional or general arteriolar or venous dilation | 38MKAJ 2C,4874,1982 |
| skin/guinea pig | lowest published lethal dose: 5 gm/kg | 38MKAJ 2C,4874,1982 | |
| skin/rabbit | lethal dose (50 percent kill): 200 mg/kg | ZAARAM 19,225,1969 | |
| subcutaneous/frog | lowest published lethal dose: 4800 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | AIPTAK 5,161,1899 |
| subcutaneous/rabbit | lowest published lethal dose: 9 mg/kg | Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Lung, Thorax, or Respiration: Respiratory stimulation Gastrointestinal: Hypermotility, diarrhea | AIPTAK 5,161,1899 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.1 mg/m3, Skin, JUN2003 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYRONITRILE-air | 10H time-weighted average 8 ppm | NIOSH* DHHS #92-100,1992 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division