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Registry of Toxic Effects of Chemical Substances (RTECS)

Propyne

RTECS #

UK4250000

CAS #

74-99-7

Updated

September 201

Molecular Weight

40.07

Molecular Formula

C3H4

Synonyms

1-Propyne (9CI)
Acetylene, methyl-
Allylene
Methyl acetylene
Methyl acetylene (ACGIH:OSHA)
Propine
Propyne (OSHA)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster8 pph/24H (-enzymatic activation step)MUREAV 652,122,2008
mutation in microorganisms/Escherichia coli5 pph (+enzymatic activation step)HPV096 -,-,2003
mutation in microorganisms/Escherichia coli10 pph (-enzymatic activation step)MUREAV 307,335,1994
mutation in microorganisms/Escherichia coli25 pph (-enzymatic activation step)MUREAV 307,335,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 47000 mg/m3/7MBehavioral: Excitement

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands		VCVGH* -,73,1990
inhalation/rat lethal concentration (50 percent kill): 135000 mg/m3TOVEFN (4),16,1997
inhalation/rat Lethal concentration: >42000 ppm/6HBehavioral: General anesthetic

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia		AMIHAB 15,20,1957
inhalation/rat lowest published toxic concentration: 47000 mg/m3/7MBehavioral: Excitement

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands		VCVGH* -,73,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 28700 ppm/6H/26W- intermittentEye: Mydriasis (pupilliary dilation)

Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands		AMIHAB 15,20,1957
inhalation/Dog lowest published toxic concentration: 28700 ppm/24W- intermittentBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV096 -,-,2003
inhalation/rat lowest published toxic concentration: 28700 ppm/6H/26W- intermittentBehavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHAB 15,20,1957
inhalation/rat lowest published toxic concentration: 28700 ppm/24W- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HPV096 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1000 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (1650 mg/m3)DTLVS* 3,153,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (1640 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (1650 mg/m3);KZW 2000 ppm (3300 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (1664 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1000 ppm (1650 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (1700 mg/m3), short term exposure limit 1300 ppm (2200 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (1650 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1000 ppm (1650 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (1650 mg/m3), short term exposure limit 1250 ppm (2040 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (1650 mg/m3);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (1640 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (1639 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (1650 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1650 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (1650 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (1650 mg/m3), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (1650 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (1650 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (1650 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (1650 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACETYLENE-air10H time-weighted average 1000 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 46435; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 119; Total Number of Female Employees Exposed 6
National Occupational Hazard Survey 1974Hazard Code 46435; Number of Industries 9; Total Number of Facilities 311; Number of Occupations 13; Total Number of Employees Exposed 5033

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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