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Registry of Toxic Effects of Chemical Substances (RTECS)

Silicic acid, tetramethyl ester

RTECS #

VV9800000

CAS #

681-84-5

Updated

September 201

Molecular Weight

152.25

Molecular Formula

C4H12O4Si

Synonyms

Methyl silicate
Methyl silicate (ACGIH)
Silicic acid, methyl ester of ortho-
Tetramethoxysilane
Tetramethyl silicate
Tetramethylsilikat (Czech)
TL 190

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 1 gm/m3/10MEye: Other eye effects

Musculoskeletal: Other changes		NDRC** NDCrc-132,MAY1942
inhalation/rat Lowest published lethal concentration: 250 ppm/4HAMIHBC 4,119,1951
intraperitoneal/mouse lethal dose (50 percent kill): 250 mg/kgCBCCT* 2,56,1950
intraperitoneal/rat lethal dose (50 percent kill): 100 mg/kg85JCAE -,1222,1986
intravenous/rabbit lowest published lethal dose: 100 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)		30ZNA5 3,935,1968
oral/mammal (species unspecified) lethal dose (50 percent kill): 1 gm/kgGISAAA 39(4),86,1974
oral/rat lowest published lethal dose: 700 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)30ZNA5 3,935,1968
skin/rabbit lethal dose (50 percent kill): 17 mL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 30 ppm/6H/28D- intermittentBehavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases		NTIS** OTS0523612
inhalation/rat lowest published toxic concentration: 20 ppm/6H/5D- intermittentLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage		NTIS** OTS0523612

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 5 ppm (30 mg/m3)DTLVS* 3,169,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (6 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (6 mg/m3);KZW 2 ppm (12 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (6 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 1 ppm (6 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (32 mg/m3), short term exposure limit 10 ppm (63 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (6 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 1 ppm (6 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 ppm (6 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (6 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (6 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (6,2 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (6 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 6 mg/m3, 2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (30 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (30 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL SILICATE-air10H time-weighted average 1 ppmNIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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