Registry of Toxic Effects of Chemical Substances (RTECS)
Succinonitrile, tetramethyl-
RTECS #
WN4025000CAS #
3333-52-6Updated
September 201Molecular Weight
136.22Molecular Formula
C8H12N2Synonyms
2,2,3,3-TetramethylbutanedinitrileButanedinitrile, tetramethyl- (9CI)
CP 75475
Tetramethyl succinonitrile
Tetramethyl succinonitrile (ACGIH:OSHA)
Tetramethylbutanedinitrile
Tetramethylsuccinic acid dinitrile
Tetramethylsuccinodinitrile
Tetramethylsuccinonitrile
Tetramethylsukcinonitril (Czech)
TMSN
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/hamster | 9944 µg/kg (8D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 3,41,1983 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
inhalation/cat | Lethal concentration: >281 mg/m3/2H | ATXKA8 16,367,1957 | |
inhalation/mouse | Lowest published lethal concentration: 125 mg/m3/2H | Behavioral: Convulsions or effect on seizure threshold | ATXKA8 16,367,1957 |
inhalation/rat | Lowest published lethal concentration: 60 ppm/2H | FEPRA7 8,205,1949 | |
intraperitoneal/mouse | lethal dose (50 percent kill): 17710 µg/kg | Behavioral: Convulsions or effect on seizure threshold | JPETAB 223,635,1982 |
intraperitoneal/rat | lethal dose (50 percent kill): 17500 µg/kg | ATXKA8 16,367,1957 | |
intravenous/mouse | lethal dose (50 percent kill): 18 mg/kg | CSLNX* NX#00002 | |
intravenous/rabbit | lethal dose (50 percent kill): 20 mg/kg | FEPRA7 8,205,1949 | |
oral/guinea pig | lethal dose (50 percent kill): 17500 µg/kg | ATXKA8 16,367,1957 | |
oral/rabbit | lowest published lethal dose: 25 mg/kg | Behavioral: Convulsions or effect on seizure threshold | ATXKA8 16,367,1957 |
oral/rat | lethal dose (50 percent kill): 27 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Pulmonary emboli | NTIS** OTS0555206 |
skin/rabbit | lowest published lethal dose: 79400 µg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Muscle weakness Lung, Thorax, or Respiration: Pulmonary emboli | NTIS** OTS0555206 |
subcutaneous/Dog | lowest published lethal dose: 20 mg/kg | FEPRA7 8,205,1949 | |
subcutaneous/guinea pig | lethal dose (50 percent kill): 23 mg/kg | FEPRA7 8,205,1949 | |
subcutaneous/mouse | lowest published lethal dose: 30 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes | ATXKA8 16,367,1957 |
subcutaneous/rabbit | lowest published lethal dose: 30 mg/kg | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Other changes | ATXKA8 16,367,1957 |
subcutaneous/rat | lethal dose (50 percent kill): 30 mg/kg | FEPRA7 8,205,1949 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | lowest published toxic dose: 270 mg/kg/90D- continuous | Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FAATDF 7,41,1986 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.5 ppm (skin) | DTLVS* TLV/BEI,2013 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.5 ppm (3 mg/m3) (skin) | DTLVS* 3,254,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 ppm (2.8 mg/m3), JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.5 ppm (3 mg/m3);KZW 2 ppm (12 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.5 ppm (2.8 mg/m3), Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.5 ppm (3 mg/m3), skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 ppm (0.5 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.5 ppm (3 mg/m3), Skin, FEB2006 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.5 ppm (3 mg/m3), skin, NOV2011 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.5 ppm (3 mg/m3), skin, 2006 | |
Occupational Exposure Limit-MEXICO | time-weighted average 0.5 ppm (3 mg/m3);short term exposure limit 2 ppm (9 mg/m3) (skin), 2004 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 ppm (2.8 mg/m3), skin, JAN2002 | |
Occupational Exposure Limit-PERU | time-weighted average 0,5 ppm (2,8 mg/m3), JUL2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.5 ppm (3 mg/m3), KZG-week 1 ppm (6 mg/m3), skin, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 3 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 0.5 ppm (3 mg/m3), Skin, JAN1993 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 0.5 ppm (3 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 0.5 ppm (3 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 0.5 ppm (3 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 0.5 ppm (3 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYL SUCCINONITRILE-air | 10H time-weighted average 0.5 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
Status in Federal Agencies
Organization | Reference |
---|---|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division