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Registry of Toxic Effects of Chemical Substances (RTECS)

Toluene, o-chloro-

RTECS #

XS9000000

CAS #

95-49-8

Updated

September 201

Molecular Weight

126.59

Molecular Formula

C7H7Cl

Synonyms

1-Chloro-2-methylbenzene
1-Methyl-2-chlorobenzene
2-Chloro-1-methylbenzene
2-Chlorotoluene
2-Methylchlorobenzene
Benzene, 1-chloro-2-methyl- (9CI)
Halso 99
o-Chlorotoluene
o-Chlorotoluene (ACGIH)
o-Tolyl chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µL moderateNTIS** OTS0572387

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 4400 ppmBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		85INA8 6,308,1991
inhalation/mouse Lowest published lethal concentration: 4400 ppmBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		85INA8 6,308,1991
inhalation/rat Lowest published lethal concentration: 4400 ppmBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation		85INA8 6,308,1991
inhalation/rat lethal concentration (50 percent kill): 7119 mg/kg/4HHPV080 -,-,2001
oral/cat Lethal dose: >500 mg/kgHPV080 -,-,2001
oral/Dog Lethal dose: >1083 mg/kgHPV080 -,-,2001
oral/duck Lethal dose: >5410 mg/kgHPV080 -,-,2001
oral/mouse lethal dose (50 percent kill): 3776 mg/kgHPV080 -,-,2001
oral/mouse lethal dose (50 percent kill): 2500 mg/kgEye: Other eye effects

Behavioral: Tremor

Behavioral: Excitement		GTPZAB 25(10),56,1981
oral/rat lethal dose (50 percent kill): 2100 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Gastritis		HPV080 -,-,2001
oral/rat lethal dose (50 percent kill): 1659 mg/kgHPV080 -,-,2001
oral/rat lethal dose (50 percent kill): 3900 mg/kgEye: Other eye effects

Behavioral: Tremor

Behavioral: Excitement		GTPZAB 25(10),56,1981
oral/wild bird Lethal dose: >5410 mg/kgHPV080 -,-,2001
skin/rabbit Lethal dose: >2165 mg/kgHPV080 -,-,2001
unreported route/guinea pig lethal dose (50 percent kill): 3 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression		GISAAA 46(2),67,1981
unreported route/mouse lethal dose (50 percent kill): 4400 mg/kgGISAAA 45(12),64,1980
unreported route/rat lethal dose (50 percent kill): 5700 mg/kgGISAAA 45(12),64,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 16 gm/m3/6H/23D- intermittentBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Urine volume increased

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0537026
inhalation/rat lowest published toxic concentration: 11400 mg/m3/6H/14D- intermittentBehavioral: Food intake (animal)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain		NTIS** OTS0537026
oral/rat lowest published toxic dose: 35910 mg/kg/9W- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Other changes		GISAAA 46(2),67,1981

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (259 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (250 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (263 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (285 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (260 mg/m3), short term exposure limit 75 ppm (390 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (250 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (285 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (250 mg/m3), short term exposure limit 75 ppm (375 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (250 mg/m3);short term exposure limit 75 ppm (375 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (259 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (259 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (250 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 250 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CHLOROTOLUENE-air10H time-weighted average 50 ppm;short term exposure limit 75 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code X1254; Number of Industries 2; Total Number of Facilities 62; Number of Occupations 8; Total Number of Employees Exposed 11617; Total Number of Female Employees Exposed 963

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database

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