Registry of Toxic Effects of Chemical Substances (RTECS)
Toluene, 2,4,6-trinitro-
RTECS #
XU0175000CAS #
118-96-7Updated
December 2013Molecular Weight
227.15Molecular Formula
C7H5N3O6Synonyms
2,4,6-Trinitrotolueen (Dutch)2,4,6-Trinitrotoluene
2,4,6-Trinitrotoluene (ACGIH:OSHA)
2,4,6-Trinitrotoluol (German)
2-Methyl-1,3,5-trinitrobenzene
alpha-TNT
Benzene, 2-methyl-1,3,5-trinitro-
Entsufon
NCI-C56155
s-Trinitrotoluene
s-Trinitrotoluol
sym-Trinitrotoluene
sym-Trinitrotoluol
TNT
TNT (OSHA)
TNT-tolite (French)
Tolit
Tolite
Trinitrotoluene
Tritol
Triton
Trojnitrotoluen (Polish)
Trotyl
Trotyl oil
Skin and Eye Irritation and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
skin /rabbit | 500 mg/24H | mild | NTIS** AD-B011-150 |
Mutation Data and Reference
System Test | Route/Organism/Tissue | Dose | Reference |
---|---|---|---|
body fluid assay | Salmonella typhimurium/rat | 50 mg/kg | MUREAV 262,167,1991 |
DNA Damage | other cell types/human | 50 µmol/L/12H | MUTAEX 28,515,2013 |
DNA repair | other cell types/human | 50 µmol/L/12H | MUTAEX 28,515,2013 |
mutation in mammalian somatic cells | lymphocyte/mouse | 40 mg/L | CALEDQ 20,103,1983 |
mutation in microorganisms | /Salmonella typhimurium | 10 µg/plate (+/-enzymatic activation step) | NTIS** AD-A080-146 |
specific locus test | ovary/hamster | 30 ppm/5H (+/-enzymatic activation step) | JJATDK 20,441,2000 |
Reproductive Effects Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/rat | 5376 mg/kg (28D male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | JTEHD6 9,565,1982 |
oral/rat | 3600 mg/kg (2W male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands | NEZAAQ 55,129,2000 |
oral/rat | 2400 mg/kg (8W male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | WDZAEK 8,25,1994 |
oral/mouse | 3 gm/kg (5D male) | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | WDZAEK 5,282,1991 |
oral/monkey | 2250 mg/kg (13W male) | Reproductive: Paternal effects: Testes, epididymis, sperm duct | WDZAEK 8,89,1994 |
Acute Toxicity Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
intraperitoneal/rat | lowest published toxic dose: 10 mg/kg | Vascular: BP elevation not characterized in autonomic section Vascular: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ARTODN 79,705,2005 |
oral/cat | lowest published lethal dose: 1850 mg/kg | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis Skin: After systemic exposure: Dermatitis, allergic | MRCSAB 58,32,1921 |
oral/human | lowest published lethal dose: 28 gm/kg | Behavioral: Hallucinations, distorted perceptions Lung, Thorax, or Respiration: Cyanosis Gastrointestinal: Other changes | 34ZIAG -,610,1969 |
oral/mouse | lethal dose (50 percent kill): 660 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | JTEHD6 9,565,1982 |
oral/mouse | lethal dose (50 percent kill): 660 mg/kg | ENTOX* -,391,2005 | |
oral/rabbit | lowest published lethal dose: 500 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea Lung, Thorax, or Respiration: Cyanosis | MRCSAB 58,32,1921 |
oral/rat | lethal dose (50 percent kill): 795 mg/kg | ENTOX* -,391,2005 | |
oral/rat | lethal dose (50 percent kill): 607 mg/kg | Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder | IJTOFN 19,169,2000 |
subcutaneous/cat | lowest published lethal dose: 200 mg/kg | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis Skin: After systemic exposure: Dermatitis, allergic | MRCSAB 58,32,1921 |
subcutaneous/rabbit | lowest published lethal dose: 500 mg/kg | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea Lung, Thorax, or Respiration: Cyanosis | MRCSAB 58,32,1921 |
Tank with water/Minnow | lethal concentration (50 percent kill): 2.3 mg/L/10D | EESADV 73,718,2010 |
Other Multiple Dose Data and References
Route/Organism | Dose | Effect | Reference |
---|---|---|---|
oral/Dog | lowest published toxic dose: 182 mg/kg/13W- continuous | Liver: Changes in liver weight Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTEHD6 9,565,1982 |
oral/Dog | lowest published toxic dose: 1456 mg/kg/26W- intermittent | Liver: Changes in liver weight Blood: Normocytic anemia Blood: Changes in spleen | TXCYAC 63,233,1990 |
oral/domestic bird | lowest published toxic dose: 3400 mg/kg/17D- intermittent | Behavioral: Tremor Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | IJTOFN 24,221,2005 |
oral/domestic bird | lowest published toxic dose: 6200 mg/kg/31D- intermittent | Behavioral: Tremor Behavioral: Ataxia Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | IJTOFN 24,221,2005 |
oral/domestic bird | lowest published toxic dose: 4200 mg/kg/60D- intermittent | Liver: Changes in liver weight Blood: Hemorrhage | IJTOFN 24,221,2005 |
oral/domestic bird | lowest published toxic dose: 2000 mg/kg/10D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | IJTOFN 24,221,2005 |
oral/domestic bird | lowest published toxic dose: 7200 mg/kg/60D- intermittent | Gastrointestinal: Decreased motility or constipation Nutritional and Gross Metabolic: Body temperature decrease Kidney, Ureter, and Bladder: Changes in kidney weight | IJTOFN 24,221,2005 |
oral/domestic bird | lowest published toxic dose: 7200 mg/kg/60D- intermittent | Related to Chronic Data: Changes in ovarian weight | IJTOFN 24,221,2005 |
oral/domestic bird | lowest published toxic dose: 12000 mg/kg/60D- intermittent | Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | IJTOFN 24,221,2005 |
oral/mouse | lowest published toxic dose: 7700 mg/kg/14D- continuous | Endocrine: Changes in spleen weight | IJTOFN 19,5,2000 |
oral/mouse | lowest published toxic dose: 924 mg/kg/14D- continuous | Immunological Including Allergic: Decrease in cellular immune response | IJTOFN 19,5,2000 |
oral/mouse | lowest published toxic dose: 3962 mg/kg/14D- continuous | Endocrine: Other changes Blood: Changes in spleen | IJTOFN 19,5,2000 |
oral/mouse | lowest published toxic dose: 2030 mg/kg/14D- continuous | Blood: Changes in spleen | IJTOFN 19,5,2000 |
oral/mouse | lowest published toxic dose: 11 mg/kg/13W- continuous | Liver: Changes in liver weight Endocrine: Changes in spleen weight Blood: Changes in spleen | JTEHD6 9,565,1982 |
oral/mouse | lowest published toxic dose: 3600 mg/kg/6W- intermittent | Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | JOCHFV 40,276,1998 |
oral/mouse | lowest published toxic dose: 560 mg/kg/14D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | WDZAEK 6,135,1992 |
oral/quail | lowest published toxic dose: 1358 mg/kg/14D- continuous | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TOXID9 54,29,2000 |
oral/rat | lowest published toxic dose: 531 mg/kg/7D- intermittent | Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | IJTOFN 19,169,2000 |
oral/rat | lowest published toxic dose: 7200 mg/kg/6W- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in testicular weight | TOLED5 55,343,1991 |
oral/rat | lowest published toxic dose: 11375 mg/kg/13W- continuous | Behavioral: Food intake (animal) Blood: Normocytic anemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 32,253,1984 |
oral/rat | lowest published toxic dose: 3 gm/kg/30D- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase Biochemical: Metabolism (intermediary): Lipids including transport | GTPZAB 18(10),57,1974 |
subcutaneous/rabbit | lowest published toxic dose: 4550 mg/kg/13W- intermittent | Liver: Other changes Blood: Other changes Blood: Changes in leukocyte (WBC) count | NEZAAQ 18,175,1963 |
unreported route/rat | lowest published toxic dose: 2800 mg/kg/8W- intermittent | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | WDZAEK 6,75,1992 |
Reviews
Organization | Standard | Reference |
---|---|---|
American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (skin) | DTLVS* TLV/BEI,2013 |
International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 65,449,1996 |
International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 65,449,1996 |
International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 65,449,1996 |
TOXICOLOGY REVIEW | NTIS** AD778-725 | |
TOXICOLOGY REVIEW | CRTXB2 1(1),93,1971 | |
TOXICOLOGY REVIEW | PAREAQ 4,1,1952 | |
TOXICOLOGY REVIEW | TOLED5 134,17,2002 | |
TOXICOLOGY REVIEW | DIMON* 39,678,1993 | |
TOXICOLOGY REVIEW | ENTOX* -,391,2005 |
Standards and Regulations
Organization | Standard | Reference |
---|---|---|
Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 0.2 ppm (0.5 mg/m3) (skin) | DTLVS* 3,270,1971 |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 0.5 mg/m3, JAN1993 | |
Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.5 mg/m3, JUL2008 | |
Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.01 ppm (0.1 mg/m3);KZW 0.04 ppm (0.4 mg/m3), skin, 2007 | |
Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3, Skin, MAR2002 | |
Occupational Exposure Limit-DENMARK | time-weighted average 0.1 mg/m3, skin, MAY2011 | |
Occupational Exposure Limit-FINLAND | time-weighted average 0.1 mg/m3, short term exposure limit 0.2 mg/m3, skin, NOV2011 | |
Occupational Exposure Limit-FRANCE | VME 0.5 mg/m3, Skin, FEB2006 | |
Occupational Exposure Limit-HUNGARY | time-weighted average 0.09 mg/m3, short term exposure limit 0.36 mg/m3, Skin, SEP2000 | |
Occupational Exposure Limit-ICELAND | time-weighted average 0.1 mg/m3, skin, NOV2011 | |
Occupational Exposure Limit-JAPAN | Occupational Exposure Limit 0.1 mg/m3, skin, MAY2012 | |
Occupational Exposure Limit-KOREA | time-weighted average 0.5 mg/m3, skin, 2006 | |
Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.5 mg/m3, skin, JAN2002 | |
Occupational Exposure Limit-NORWAY | time-weighted average 0.1 mg/m3, JAN1999 | |
Occupational Exposure Limit-PERU | time-weighted average 0,1 mg/m3, JUL2005 | |
Occupational Exposure Limit-POLAND | MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999 | |
Occupational Exposure Limit-RUSSIA | time-weighted average 0.1 mg/m3, short term exposure limit 0.5 mg/m3, JUN2003 | |
Occupational Exposure Limit-SWEDEN | time-weighted average 0.1 mg/m3;short term exposure limit 0.2 mg/m3, Skin, JUN2005 | |
Occupational Exposure Limit-SWITZERLAND | MAK-week 0.01 ppm (0.1 mg/m3), KZG-week 0.02 ppm, carc 3, skin, sen, JAN2011 | |
Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, Skin, 2003 | |
Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 1.5 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit-TURKEY | time-weighted average 1.5 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 mg/m3, skin, OCT2007 | |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1.50 mg/m3 (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1.50 mg/m3 (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1.50 mg/m3 (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1.50 mg/m3 (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
Organization | Standard | Reference |
---|---|---|
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4,6-TRINITROTOLUENE-air | 10H time-weighted average 0.5 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 | Hazard Code 74550; Number of Industries 2; Total Number of Facilities 10; Number of Occupations 1; Total Number of Employees Exposed 31 |
Status in Federal Agencies
- Page last reviewed:March 7, 2014
- Page last updated:February 6, 2017
- Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division