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Registry of Toxic Effects of Chemical Substances (RTECS)

Beryllium fluoride

RTECS #

DS2800000

CAS #

7787-49-7; 12323-05-6

Updated

September 201

Molecular Weight

47.01

Molecular Formula

BeF2

Synonyms

Beryllium difluoride

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 µg/m3/1H/17W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		GTPZAB 19(7),34,1975
inhalation/rat toxic concentration (other than lowest): 49 µg/m3/26WTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors		PEXTAR 2,203,1961

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/hamster lethal dose (50 percent kill): 21 mg/kgXEURAQ UR-154,1951
intravenous/mouse lethal dose (50 percent kill): 1800 µg/kgXPHPAW 2173,23,1972
oral/mouse lethal dose (50 percent kill): 18 mg/kgHBTME* -,415,2007
oral/rat lethal dose (50 percent kill): 98 mg/kgXEURAQ UR-154,1951
subcutaneous/mouse lethal dose (50 percent kill): 20 mg/kgXPHPAW 2173,23,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 10 mg/m3/6H/30W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainAMIHBC 8,493,1953
inhalation/Dog lowest published toxic concentration: 1 mg/m3/6H/30W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 8,493,1953
inhalation/guinea pig lowest published toxic concentration: 10 mg/m3/6H/30W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 8,493,1953
inhalation/mammal (species unspecified) lowest published toxic concentration: 1.1 mg/m3/6H/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVN1* -,95,1988
inhalation/monkey lowest published toxic concentration: 0.184 mg/m3/7D- intermittentCardiac: Changes in heart weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		HBTME* -,415,2007
inhalation/mouse lowest published toxic concentration: 10 mg/m3/6H/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		AMIHBC 8,493,1953
inhalation/rabbit lowest published toxic concentration: 1 mg/m3/6H/30W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes		AMIHBC 8,493,1953
inhalation/rabbit lowest published toxic concentration: 2.2 mg/m3/23W- intermittentBlood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVN1* -,95,1988
inhalation/rat lowest published toxic concentration: 0.4 mg(Be)/m3/1H/16W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVN1* -,95,1988
inhalation/rat lowest published toxic concentration: 0.4 mg(Be)/m3/1H/78W- intermittentLung, Thorax, or Respiration: Bronchogenic carcinoma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field		VCVN1* -,95,1988
inhalation/rat lowest published toxic concentration: 1 mg/m3/6H/30W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAMIHBC 8,493,1953

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.00005 mg(Be)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2.5 mg(F)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 23,143,1980
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 58,41,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 58,41,1993
TOXICOLOGY REVIEWCTOXAO 6,497,1973
TOXICOLOGY REVIEWAMIHBC 8,1,1953
TOXICOLOGY REVIEWMUREAV 533,183,2003
TOXICOLOGY REVIEWHBTME* ,415,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.002 mg(Be)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-BELGIUMtime-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.001 mg(Be)/m3 (dust), carc, MAY2011
Occupational Exposure Limit-ECtime-weighted average 2.5 mg(F)/m3, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 2.5 mg(F)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.002 mg(Be)/m3, C2 Carcinogen, FEB2006
Occupational Exposure Limit-FRANCEVME 2.5 mg(F)/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 mg(F)/m3, inhal, 2011
Occupational Exposure Limit-HUNGARYceiling concentration 0.002 mg(Be)/m3, Carcinogen, SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit-INDIAtime-weighted average 0.002 mg(Be)/m3, Carcinogen, JAN1993
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.002 mg(Be)/m3, 2A carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.002 mg(Be)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.002 mg(Be)/m3, carcinogen, JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.001 mg(Be)/m3, JAN1999
Occupational Exposure Limit-NORWAYtime-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.001 mg(Be)/m3, MAC(short term exposure limit) 0.002 mg(Be)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.001 mg(Be)/m3, short term exposure limit 0.003 mg(Be)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.002 mg(Be)/m3, Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWEDENtime-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.002 mg(Be)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-SWITZERLANDMAK-week 1 mg(F)/m3, KZG-week 4 mg(F)/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.002 mg(Be)/m3, short term exposure limit 0.005 mg(Be)/m3, JAN1993
Occupational Exposure Limit-THAILANDtime-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.002 mg(Be)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.002 mg(Be)/m3, carc, OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2.5 mg(F)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2.5 mg(F)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2.5 mg(F)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2.5 mg(F)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.002 mg(Be)/m3CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2.5 mg(F)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-airCarcinogen not to exceed 0.0005 mg(Be)/m3NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

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