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Registry of Toxic Effects of Chemical Substances (RTECS)

Chromium(III) chloride (1:3)

RTECS #

GB5425000

CAS #

10025-73-7

Updated

July 2013

Molecular Weight

158.35

Molecular Formula

Cl₃Cr

Synonyms

C.I. 77295
Chromic chloride
Chromium chloride
Chromium trichloride
Chromium(III) chloride, anhydrous
Puratronic chromium chloride
Trichlorochromium

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/human	2500 µg/L	MUREAV 191,207,1987
Cytogenetic Analysis	fibroblast/human	100 µmol/L	CARYAB 32,379,1979
Cytogenetic Analysis	other cell types/human	500 mg/L	BJCAAI 44,219,1981
Cytogenetic Analysis	ovary/hamster	50 µg/L	CARYAB 32,379,1979
DNA Damage	lymphocyte/human	600 µmol/L	MUREAV 469,135,2000
DNA inhibition	fibroblast/mouse	300 µmol/L	JTEHD6 15,237,1985
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	40 mmol/L	TECSDY 13,103,1986
micronucleus test	fibroblast/human	1 µmol/L/24H	MUREAV 490,99,2001
mutation in microorganisms	/Salmonella typhimurium	2 µmol/plate (+enzymatic activation step)	EESADV 9,92,1985
mutation in microorganisms	/Saccharomyes cerevisiae	80 mmol/L (+/-enzymatic activation step)	TECSDY 13,103,1986
other mutation test systems	/Bacillus subtilis	30 µmol/L	BECTA6 43,254,1989
phage inhibition capacity	/Escherichia coli	500 µmol/L	ENMUDM 6,59,1984
sister chromatid exchange	fibroblast/hamster	1 mg/L	MUREAV 104,141,1982
specific locus test	ovary/hamster	0.5 mmol/L/48H	MUREAV 513,135,2002
sperm morphology	oral/rat	45750 µg/kg/26W-continuous	GISAAA 50(7),31,1985
Unscheduled DNA Synthesis	fibroblast/human	100 µmol/L	DCTODJ 4,185,1981

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	44600 µg/kg (8D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear	JTSCDR 1(2),1,1976
intraperitoneal/mouse	30 mg/kg (8D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JTSCDR 1(2),1,1976
intraperitoneal/mouse	59500 µg/kg (9D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	JTSCDR 1(2),1,1976
intraperitoneal/mouse	59500 µg/kg (8D pregnant)	Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)	JTSCDR 1(2),1,1976
intraperitoneal/mouse	158.35 mg/kg (1D male)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects	TOXID9 78,337,2004
intratesticular/rat	12668 µg/kg (1D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	JRPFA4 7,21,1964
intravenous/hamster	8 mg/kg (8D pregnant)	Reproductive: Other developmental abnormalities	VCVN5* -,301,1989
oral/mouse	84 gm/kg (12W male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	TXCYAC 116,39,1997
oral/mouse	33600 mg/kg (12W prior to copulation)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	TXCYAC 116,39,1997
subcutaneous/mouse	450 mg/kg (1-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TJADAB 12,198,1975
subcutaneous/mouse	12668 µg/kg (30D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	JRPFA4 7,21,1964
unreported route/mouse	158.35 mg/kg (1D male)	Reproductive: Effects on newborn: Biochemical and metabolic	TOXID9 60,205,2001

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (50 percent kill): 31500 µg/m³/2H		85GMAT -,39,1982
inhalation/mouse	lethal concentration (50 percent kill): 31.5 mg/m³		VCVN5* -,301,1993
intramuscular/mouse	lethal dose (50 percent kill): 40 mg/kg		85GMAT -,39,1982
intraperitoneal/guinea pig	lowest published lethal dose: 200 mg/kg		AEHLAU 11,201,1965
intraperitoneal/mouse	lowest published toxic dose: 12 mg/kg	Behavioral: Wakefulness	PHREP* 60,991,2008
intraperitoneal/mouse	lowest published toxic dose: 32 mg/kg	Behavioral: Change in motor activity (specific assay)	PHREP* 60,991,2008
intraperitoneal/mouse	lethal dose (50 percent kill): 143 mg/kg		COREAF 256,1043,1963
intravenous/mouse	lowest published lethal dose: 400 mg/kg		AQMOAC #70-15,1970
intravenous/rabbit	lowest published lethal dose: 288 mg/kg		EQSSDX 1,1,1975
oral/rat	lethal dose (50 percent kill): 440 mg/kg		VCVN5* -,301,1993
skin/guinea pig	lowest published lethal dose: 202 mg/kg		AEHLAU 11,201,1965
subcutaneous/mouse	lowest published lethal dose: 800 mg/kg		AQMOAC #70-15,1970
subcutaneous/mouse	lethal dose (50 percent kill): 7.8 mg/kg		VCVN5* -,301,1993

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	lowest published toxic dose: 450 mg/kg/3D- intermittent	Cardiac: Other changes Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	WDZAEK 6,205,1992
oral/chicken	lowest published toxic dose: 4.9 mg/kg/28D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	JAPTO* 22,161,2002
oral/mouse	lowest published toxic dose: 33600 mg/kg/12W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TXCYAC 116,39,1997

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 49,49,1990
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 49,49,1990
TOXICOLOGY REVIEW		85DHAX Cr,22,1974
TOXICOLOGY REVIEW		CRTXB2 33,215,2003
TOXICOLOGY REVIEW		MUREAV 533,36,2003
TOXICOLOGY REVIEW		HBTME* ,487,2007
TOXICOLOGY REVIEW		HBTME* ,213,2007
TOXICOLOGY REVIEW		MUTAEX 22,161,2007
TOXICOLOGY REVIEW		MUTAEX 23,271,2008

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 mg(Cr)/m³	DTLVS* 3,35,1971
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 mg(Cr)/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 0.5 mg(Cr)/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.005 mg(Cr)/m³, MAY2011
Occupational Exposure Limit-EC	time-weighted average 2 mg(Cr)/m³, FEB2006
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 0.5 mg(Cr)/m³, a2 sen, s1 sen, MAY2012
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 mg(Cr)/m³, JAN2002
Occupational Exposure Limit-SWEDEN	time-weighted average 0.5 mg(Cr)/m³, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 mg(Cr)/m³, inhal, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.5 mg(Cr)/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 mg(Cr)/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 0.5 mg(Cr)/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 0.5 mg(Cr)/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 mg(Cr)/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 84456; Number of Industries 4; Total Number of Facilities 338; Number of Occupations 9; Total Number of Employees Exposed 3273; Total Number of Female Employees Exposed 1706
National Occupational Hazard Survey 1974	Hazard Code 84456; Number of Industries 2; Total Number of Facilities 32; Number of Occupations 3; Total Number of Employees Exposed 268

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

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Page last reviewed:March 7, 2014
Page last updated:February 6, 2017
Content source:
- National Institute for Occupational Safety and Health (NIOSH) Education and Information Division

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