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Registry of Toxic Effects of Chemical Substances (RTECS)

Silica, crystalline - cristobalite

RTECS #

VV7325000

CAS #

14464-46-1; 1317-48-2; 105269-70-3

Updated

September 201

Molecular Weight

60.09

Molecular Formula

O2Si

Synonyms

43-63C
alpha-Crystobalite
Calcined diatomaceous earth
Calcined diatomite
Cristobalite
Crysvarl
Metacristobalite
Silica, crystalline-cristobalite (ACGIH:OSHA)
W 006
WGL 300

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intrapleural/rat lowest published toxic dose: 90 mg/kgTumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease		JNCIAM 57,509,1976
intrapleural/rat toxic dose: 100 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease		BJCAAI 41,908,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 16 million particles per cubic foot/8H/17.9Y- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea		NTIS** PB246-697
intratracheal/rat lowest published lethal dose: 200 mg/kgLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)BJIMAG 10,9,1953
intratracheal/rat lowest published toxic dose: 10 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXCYAC 195,155,2004
intratracheal/rat lowest published toxic dose: 20 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation		TXCYAC 195,155,2004

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 70 mg/m3/5H/12D- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes		JEPOEC 17,99,1998
inhalation/mouse lowest published toxic concentration: 43 mg/m3/5H/9D- intermittentLung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Other changes		JEPOEC 17,81,1998

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.025 mg/m3 (resp)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 68,41,1997
International Agency for Research on Cancer (IARC)Cancer Review:Human Limited EvidenceIMEMDT 42,39,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 68,41,1997
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 68,41,1997
TOXICOLOGY REVIEWANAEA3 35,165,1975
TOXICOLOGY REVIEW31BYAP -,93,1974

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-respirable dust in airtime-weighted average 10 mg/m3/2(% resp. SiO2+2)DTLWS* 3,33,1973
Mine Safety and Health Administration (MSHA) STANDARD-total dust in airtime-weighted average 30 mg/m3/2(% SiO2+3)DTLWS* 3,33,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 mg/m3 (resp. dust), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg/m3 (respirable), carc, MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.15 mg/m3 (total dust), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.15 mg/m3 (total), MAY2011
Occupational Exposure Limit-FRANCEVME 0.05 mg/m3, (resp), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 mg/m3 (resp. dust), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.5 mg/m3 (resp. dust), 2 mg/m3 (total dust), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 mg/m3 (respirable), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg/m3 (respirable dust), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg/m3 (resp.), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,05 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3 (total dust), JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.05 mg/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.15 mg/m3, carc 1, resp, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.075 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg/m3 (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3/(% resp SiO2+2)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3/(% resp SiO2+2)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 20 mppcf/(%SiO2+5)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SILICA, cryst. cristobalite-air10H Carcinogen time-weighted average 0.05 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code T0624; Number of Industries 33; Total Number of Facilities 2072; Number of Occupations 43; Total Number of Employees Exposed 31369; Total Number of Female Employees Exposed 2228

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Silica, crystalline, by XRD, 7500; by VIS, 7600; by IR, 7602
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-125G, SUPERSEDED BY ID142

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