Monomethyl aniline

CAS number: 100–61–8

NIOSH REL: 0.5 ppm (2 mg/m³) TWA [skin]

Current OSHA PEL: 2 ppm (9 mg/m³) TWA [skin]

1989 OSHA PEL: 0.5 ppm (2 mg/m³) TWA [skin]

1993-1994 ACGIH TLV: 0.5 ppm (2.2 mg/m³) TWA [skin]

Description of substance: Yellow to light-brown liquid with a weak, ammonia-like odor.

LEL: . . . Unknown

Original (SCP) IDLH: 100 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on an analogy with aniline which has an IDLH of 100 ppm.

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal dose data:

Species	Reference	Route	LD50 (mg/kg)	LDLo (mg/kg)	Adjusted LD	Derived value
Rabbit G. pig	Treon et al. 1949 von Oettingen 1941	oral oral	----- -----	280 1,200	439 ppm 1,883 ppm	44 ppm 188 ppm

Other animal data: It has been reported that a dog survived 50 seven-hour exposures to 86 ppm [Treon et al. 1949].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 100 ppm [Unchanged] Basis for revised IDLH: Based on animal subchronic inhalation toxicity data [Treon et al. 1949] and an analogy to aniline which has a revised IDLH of 100 ppm, the original IDLH for monomethyl aniline (100 ppm) is not being revised at this time.

REFERENCES:

1. Treon JF, Deichmann WB, Sigmon HE, Wright H, Witherup SO, Heyroth FF, Kitzmiller KV, Keenan C [1949]. The toxic properties of xylidine and monomethylaniline. I. The comparative toxicity of xylidine and monomethylaniline when administered orally or intravenously to animals or applied on their skin. J Ind Hyg Toxicol 31:1-20.

2. von Oettingen WF [1941]. The aromatic amino and nitro compounds, their toxicity and potential dangers. Public Health Bulletin 271:16.