Diglycidyl ether

CAS number: 2238–07–5

NIOSH REL: 0.1 ppm (0.5 mg/m³) TWA; NIOSH considers diglycidyl ether to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990].

Current OSHA PEL: 0.5 ppm (2.8 mg/m³) CEILING

1989 OSHA PEL: 0.1 ppm (0.5 mg/m³) TWA

1993-1994 ACGIH TLV: 0.1 ppm (0.53 mg/m³) TWA

Description of Substance: Colorless liquid with a strong, irritating odor.

LEL:. . Unknown

Original (SCP) IDLH: 25 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the male mouse 4-hour LC₅₀ of 30 ppm [Hine et al. 1956].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Mouse Mouse Mouse Rat Rat Rat	Hine et al. 1956 Hine et al. 1961 Hine et al. 1961 Hine et al. 1961 Hine et al. 1961 Marhold 1986	30 86 30 200 68 200	----- ----- ----- ----- ----- -----	4 hr 4 hr 8 hr 4 hr 8 hr 4 hr	60 ppm (2.0) 192 ppm (2.0) 75 ppm (2.5) 400 ppm (2.0) 170 ppm (2.5) 400 ppm (2.0)	6.0 ppm 19 ppm 7.5 ppm 40 ppm 17 ppm 40 ppm

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 10 ppm Basis for revised IDLH: The revised IDLH for diglycidyl ether is 10 ppm based on acute inhalation toxicity data in animals [Hine et al. 1956; Hine et al. 1961]. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for diglycidyl ether at concentrations above 0.1 ppm.]

REFERENCES:

1. Hine CH, Kodama JK, Wellington JS, Dunlap MK, Anderson HH [1956]. The toxicology of glycidol and some glycidyl ethers. AMA Arch Ind Health 14:250-264.

2. Hine CH, Kodama JK, Guzman RJ, Dunlap MK, Lima R, Loquvam GS [1961]. Effects of diglycidyl ether on blood of animals. Arch Environ Health 2(1):37/31-50/44.

3. Marhold J [1986]. Prehled Prumyslove Toxikologie, Organicke Latky. Prague, Czechoslovakia: Avicenum, p. 773 (in Czechoslovakian).