Selenium hexafluoride (as Se)

CAS number: 7783–79–1

NIOSH REL: 0.05 ppm (0.16 mg/m³) TWA

Current OSHA PEL: 0.05 ppm (0.4 mg/m³) TWA

1989 OSHA PEL: Same as current PEL

1993-1994 ACGIH TLV: 0.05 ppm (0.16 mg/m³) TWA

Description of substance: Colorless gas.

LEL :. . Nonflammable Gas

Original (SCP) IDLH: 5 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by ACGIH [1971] that 5 ppm for 4 hours resulted in pulmonary edema from which rabbits, guinea pigs, rats, and mice survived [Kimmerle 1960]; exposures to 10 ppm and greater for 4 hours were uniformly fatal to the exposed animals [Kimmerle 1960].

Short-term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species	Reference	LC50 (ppm)	LCLo (ppm)	Time	Adjusted 0.5-hr LC (CF)	Derived value
Rat Mouse G. pig	Kimmerle 1960 Kimmerle 1960 Kimmerle 1960	----- ----- -----	10 10 10	1 hr 1 hr 1 hr	13 ppm (1.25) 13 ppm (1.25) 13 ppm (1.25)	1.3 ppm 1.3 ppm 1.3 ppm

Other animal data: It has been reported that 5 ppm for 4 hours resulted in pulmonary edema from which rabbits, guinea pigs, rats, and mice survived [Kimmerle 1960].

Human data: None relevant for use in determining the revised IDLH.

Revised IDLH: 2 ppm Basis for revised IDLH: The revised IDLH for selenium hexafluoride is 2 ppm based on acute inhalation toxicity data in animals [Kimmerle 1960].

REFERENCES:

1. ACGIH [1971]. Selenium hexafluoride. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 226.

2. Kimmerle G [1960]. Vergleichende untersuchungen der inhalationstoxicitat von schwefel-, selen- und tellurhexafluorid (Comparative study of the inhalation toxicity of sulfur, selenium and tellurium hexafluorides). Arch Toxikol 18:140-144 (in German).