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NIOSH

2-METHOXYETHYL ACETATE

ICSC: 0476

Ethylene glycol monomethyl ether acetate
2-Methoxyethanol acetate
Acetic acid, 2-methoxyethyl ester
Methyl cellosolve acetate
Methyl glycol acetate
C5H10O3 / CH3COOCH2CH2OCH3
Molecular mass: 118.1
ICSC # 0476 		CAS # 110-49-6
RTECS # KL5950000
UN # 1189
EC # 607-036-00-1
November 26, 2003 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Flammable.
NO open flames, NO sparks, and NO smoking.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 45°C explosive vapour/air mixtures may be formed.
Above 45°C use a closed system, ventilation, and explosion-proof electrical equipment.
In case of fire: keep drums, etc., cool by spraying with water.
EXPOSURE
AVOID ALL CONTACT!

•INHALATION Dizziness. Drowsiness. Headache.
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Refer for medical attention.
•SKIN MAY BE ABSORBED! Dry skin. (Further see Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness.
Safety goggles, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal pain. Nausea. Vomiting. Weakness. Unconsciousness. (Further see Inhalation).
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: filter respirator for organic gases and vapours.)
Fireproof. Separated from strong oxidants, strong bases, strong acids. Keep in the dark.

Note: E
T symbol
R: 60-61-20/21/22
S: 53-45
UN Hazard Class: 3
UN Packing Group: III
ICSC: 0476 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

2-METHOXYETHYL ACETATE

ICSC: 0476

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance can presumably form explosive peroxides. Reacts with strong oxidants, strong bases .

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 0.1 ppm as TWA; (skin); (ACGIH 2007).
MAK: 5 ppm, 25 mg/m3; H;
Peak limitation category: II(8); Pregnancy risk group: B;
(DFG 2006).
OSHA PEL: TWA 25 ppm (120 mg/m3) skin
NIOSH REL: TWA 0.1 ppm (0.5 mg/m3) skin
NIOSH IDLH: 200 ppm See: 110496


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The vapour is mildly irritating to the eyes. The substance may cause effects on the bone marrow and central nervous system . The substance may cause effects on the blood , resulting in lesions of blood cells and kidney impairment at high levels . Exposure far above the OEL may result in unconsciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The liquid defats the skin. The substance may have effects on the bone marrow and blood , resulting in lesions of blood cells and kidney impairment. May cause toxicity to human reproduction or development.

PHYSICAL
PROPERTIES

Boiling point: 145°C
Melting point: -65°C
Relative density (water = 1): 1.01
Solubility in water:
miscible
Vapour pressure, kPa at 20°C: 0.27
Relative vapour density (air = 1): 4.1
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 45°C c.c.
Auto-ignition temperature: 380°C
Explosive limits, vol% in air: 1.5 (93°C) - 12.3 (93°C)
Octanol/water partition coefficient as log Pow: 0.121

ENVIRONMENTAL
DATA

The substance is harmful to aquatic organisms.

N O T E S

Check for peroxides prior to distillation; eliminate if found. Health effects of exposure to the substance have not been investigated adequately. Its effects are deduced from those of similar substances.
Transport Emergency Card: TEC (R)-30GF1-III

NFPA Code: H1; F2; R
Card has been partially updated in July 2007: see Occupational Exposure Limits.

ADDITIONAL INFORMATION



ICSC: 0476 2-METHOXYETHYL ACETATE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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