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NIOSH

PROPIONIC ANHYDRIDE

ICSC: 0558

Propanoic anhydride
Methylacetic anhydride
Propanoic acid anhydride
C6H10O3 / (CH3CH2CO)2O
Molecular mass: 130.2
ICSC # 0558 		CAS # 123-62-6
RTECS # UF9100000
UN # 2496
EC # 607-010-00-X
March 27, 1996 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION Above 63°C explosive vapour/air mixtures may be formed.
Above 63°C use a closed system, ventilation.

EXPOSURE
PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!

•INHALATION Sore throat. Cough. Burning sensation. Shortness of breath. Symptoms may be delayed (see Notes).
Ventilation, local exhaust, or breathing protection.
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
•SKIN Pain. Blisters.
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.
•EYES Redness. Pain. Severe deep burns.
Face shield, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Burning sensation. Abdominal pain. Shock or collapse. Sore throat.
Do not eat, drink, or smoke during work.
Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent and remove to safe place. Use face shield. Chemical protection suit.
Separated from bases, oxidants and food and feedstuffs. Dry. Ventilation along the floor.
Do not transport with food and feedstuffs.
C symbol
R: 34
S: 1/2-26-45
UN Hazard Class: 8
UN Packing Group: III
ICSC: 0558 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

PROPIONIC ANHYDRIDE

ICSC: 0558

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH PUNGENT ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air.

CHEMICAL DANGERS:
The substance decomposes on contact with water producing corrosive propionic acid. Reacts violently with bases and oxidants causing fire and explosion hazard.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, also as a vapour! and by ingestion.

INHALATION RISK:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of vapour or aerosol may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:

PHYSICAL
PROPERTIES

Boiling point: 167°C
Melting point: -45°C
Relative density (water = 1): 1.01
Solubility in water: reaction
Vapour pressure, kPa at 20°C: . 1
Relative vapour density (air = 1): 4.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 63°C c.c.
Auto-ignition temperature: 285°C
Explosive limits, vol% in air: 1.3-9.5

ENVIRONMENTAL
DATA


N O T E S

The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
Transport Emergency Card: TEC (R)-80GC3-II+III
NFPA Code: H3; F2; R1;

ADDITIONAL INFORMATION



ICSC: 0558 PROPIONIC ANHYDRIDE
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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