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NIOSH

VAMIDOTHION

ICSC: 0758

O,O-Dimethyl S-(2-(1-methylcarbamoylethylthio)ethyl) phosphorothioate
O,O-Dimethyl S-2-(1-N-methylcarbamoylethylmercapto)ethyl thiophosphate
N-Methyl O,O-dimethylthiolophosphoryl-5-thia-3-methyl-2-valeramide
C8H18NO4PS2
Molecular mass: 287.36
ICSC # 0758 		CAS # 2275-23-2
RTECS # TF7900000
UN # 2783
EC # 015-059-00-8
October 16, 2001 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
NO open flames.
Powder, water spray, foam, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST!
IN ALL CASES CONSULT A DOCTOR!
•INHALATION Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Laboured breathing. Convulsions. Unconsciousness.
Ventilation (not if powder), local exhaust, or breathing protection.
Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.
•SKIN MAY BE ABSORBED! (See Inhalation).
Protective gloves. Protective clothing.
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
•EYES
Face shield, or eye protection in combination with breathing protection.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION Abdominal cramps. Vomiting. Diarrhoea. (Further see Inhalation).
Do not eat, drink, or smoke during work. Wash hands before eating.
Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT wash away into sewer. (Extra personal protection: P3 filter respirator for toxic particles.)
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed.
Do not transport with food and feedstuffs.
T symbol
N symbol
R: 21-25-50
S: 1/2-36/37-45-61
UN Hazard Class: 6.1
UN Packing Group: III
ICSC: 0758 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

VAMIDOTHION

ICSC: 0758

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS CRYSTALS

PHYSICAL DANGERS:


CHEMICAL DANGERS:
The substance decomposes on burning producing toxic fumes including nitrogen oxides , phosphorous oxides and sulfur oxides .

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

INHALATION RISK:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the nervous system , resulting in convulsions and respiratory failure. Exposure at high levels may result in death. Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL
PROPERTIES

Melting point: 46-48°C
Solubility in water: very good
Vapour pressure, at room temperature: negligible

ENVIRONMENTAL
DATA

The substance is harmful to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to birds and honey bees. Avoid release to the environment in circumstances different to normal use.

N O T E S

Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s). Carrier solvents used in commercial formulations may change physical and toxicological properties.
Transport Emergency Card: TEC (R)-61GT7-III

ADDITIONAL INFORMATION



ICSC: 0758 VAMIDOTHION
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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