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NIOSH

PARACETAMOL

ICSC: 1330

Acetaminophen
4'-Hydroxyacetanilide
p-Acetylaminophenol
N-(4-Hydroxyphenyl) acetamide
C8H9NO2 / HOC6H4NHCOCH3
Molecular mass: 151.2
ICSC # 1330 		CAS # 103-90-2
RTECS # AE4200000
November 11, 2008 Validated

TYPES OF HAZARD/ EXPOSURE

ACUTE HAZARDS/ SYMPTOMS

PREVENTION

FIRST AID/
FIRE FIGHTING

FIRE Combustible.
NO open flames.
Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION


EXPOSURE
PREVENT DISPERSION OF DUST!

•INHALATION Cough.
Local exhaust or breathing protection.
Fresh air, rest.
•SKIN
Protective gloves.
Rinse and then wash skin with water and soap.
•EYES Redness.
Safety goggles
Rinse with plenty of water (remove contact lenses if easily possible).
•INGESTION
Do not eat, drink, or smoke during work.
Give one or two glasses of water to drink. : 300-500 ml of water (ref. 37);

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Personal protection: particulate filter adapted to the airborne concentration of the substance. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Do NOT let this chemical enter the environment.
Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.

Signal: Warning
Health haz
May cause damage to liver and kidneys through prolonged or repeated exposure if swallowed.
Toxic to aquatic life
ICSC: 1330 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

PARACETAMOL

ICSC: 1330

I

M

P

O

R

T

A

N

T


D

A

T

A

PHYSICAL STATE; APPEARANCE:
COLOURLESS CRYSTALS OR CRYSTALLINE POWDER

PHYSICAL DANGERS:


CHEMICAL DANGERS:


OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK not established.


ROUTES OF EXPOSURE:
The substance can be absorbed into the body by ingestion.

INHALATION RISK:
A nuisance-causing concentration of airborne particles can be reached quickly.

EFFECTS OF SHORT-TERM EXPOSURE:
ity- after ingestion of 10-15 g (140-250 mg/kg) (ref 27),29,37,40;

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
The substance may have effects on the kidneys and liver , resulting in impaired functions, when ingested. 13813100 e been detected in experimental animals but may not be relevant to humans. Peer review 11/98.; 13839000 w 11/98. chromatid breaks in peripheral human blood lymphocytes in vivo (ref. 8,25), incr. genotoxic damage in man (ref.30),34, other: not expected to cause heritable damage in man (ref.41); 13859000

PHYSICAL
PROPERTIES

Boiling point: >500°C
Melting point: 169-170°C
Density: 1.3
g/cm3
Solubility in water, g/100 ml at 20°C: 1.4
(moderate)
Relative vapour density (air = 1): 5.2
Auto-ignition temperature: 540°C
Explosive limits, vol% in air: 15 - ?
Octanol/water partition coefficient as log Pow: 0.49

ENVIRONMENTAL
DATA

The substance is toxic to aquatic organisms. It is strongly advised that this substance does not enter the environment.

N O T E S

n 24h of overdose - nausea, vomiting, lethargy; within 24-48h to 3-4d-first indication of liver damage;

ADDITIONAL INFORMATION



ICSC: 1330 PARACETAMOL
(C) IPCS, CEC, 1994
IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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