CEPP
CEPP is an acronym for the name of a chemotherapy regimen that is intended for treatment of aggressive non-Hodgkin lymphomas. Unlike CHOP, this chemotherapy regimen does not contain doxorubicin or any other anthracycline. Thus, it can be used in patients with severe cardiovascular diseases and contraindications for doxorubicin-containing regimens. There are 2 modifications of CEPP - with the addition of bleomycin, called CEPP (B), and without bleomycin - ordinary CEPP.[1]
This regimen also does not contain vincristine and can be used in patients with neuropathy.
In combination with anti-CD20, monoclonal, antibody, and rituximab. this regimen is called R-CEPP(B).
[R]-CEPP(B) regimen consists of:
- (R)ituximab - a monoclonal antibody that is able to kill CD20-positive B cells, either normal or malignant;
- (C)yclophosphamide - an alkylating antineoplastic agent;
- (E)toposide - a topoisomerase inhibitor from the epipodophyllotoxin group;
- (P)rocarbazine - an alkylating antineoplastic agent;
- (P)rednisone or (P)rednisolone - a glucocorticoid hormone that has the ability to cause apoptosis and lysis of lymphocytes, either normal or malignant;
- (B)leomycin - an antitumor antibiotic.
Dosing regimen
| Drug | Dose | Mode | Days |
|---|---|---|---|
| (R)ituximab | 375 mg/m2 | IV infusion | Day 1 |
| (C)yclophosphamide | 600 mg/m2 | IV infusion | Days 1 and 8 |
| (E)toposide | 70 mg/m2 | IV infusion | Days 1-3 |
| (P)rocarbazine | 60 mg/m2 | PO qd | Days 1-10 |
| (P)rednisone or (P)rednisolone | 60 mg/m2 | PO qd | Days 1-10 |
| (B)leomycin | 10 IU/m2 | IV bolus | Day 1 |
References
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