Cephamycin

Core structure of the cephamycins.

Cephamycin is a class of antibiotic.[1] It is a subgroup of cephalosporins.[2]

It is a type of β-lactam antibiotic[1]

Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.

Cephamycins possess a methoxy group at the 7-alpha position.[3]

In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) producing organisms, although their use in clinical practice is lacking for this indication.

Examples

Cephamycins include:

References

  1. 1 2 Ritter, James M.; Flower, Rod; Henderson, Graeme; Loke, Yoon Kong; Rang, Humphrey P. (2020). "52. Antibacterial drugs". Rang & Dale's Pharmacology (9th ed.). Elsevier. p. 665. ISBN 978-0-7020-7448-6. Archived from the original on 2021-08-28. Retrieved 2021-11-27.
  2. ↑ Bui, Toai; Preuss, Charles V. (2021). "Cephalosporins". StatPearls. StatPearls Publishing. Archived from the original on 2021-12-11. Retrieved 2021-12-02.
  3. ↑ "cephamycin (CHEBI:55429)". www.ebi.ac.uk. Retrieved 27 November 2021.
  4. ↑ Little PJ, Peddie BA (July 1978). "Clinical use of cefoxitin, a new semisynthetic cephamycin". N. Z. Med. J. 88 (616): 46–9. PMID 279853.
  5. ↑ Clarke AM, Zemcov SJ (January 1983). "Antibacterial activity of the cephamycin cefotetan: an in-vitro comparison with other beta-lactam antibiotics". J. Antimicrob. Chemother. 11. Suppl: 67–72. doi:10.1093/jac/11.suppl_A.67. PMID 6404881.
  6. ↑ Benlloch M, Torres A, Soriano F (October 1982). "Cefmetazole (CS-1170): a new cephamycin with activity against gram-negative bacilli and staphylococci". J. Antimicrob. Chemother. 10 (4): 347–50. doi:10.1093/jac/10.4.347. PMID 6958672.


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