Norwogonin

Norwogonin
Clinical data
Other names5,7,8-Trihydroxyflavone; 5,7,8-THF
Identifiers
IUPAC name
  • 5,7,8-trihydroxy-2-phenylchromen-4-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H10O5
Molar mass270.240 g·mol−1
3D model (JSmol)
SMILES
  • C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O
InChI
  • InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H
  • Key:ZFKKRRMUPBBYRS-UHFFFAOYSA-N

Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap).[1] It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).[2]

See also

  • Tropomyosin receptor kinase B § Agonists

References

  1. ↑ Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. (2013). Khan AU (ed.). "Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii". PLOS ONE. 8 (4): e61594. Bibcode:2013PLoSO...861594M. doi:10.1371/journal.pone.0061594. PMC 3632535. PMID 23630600.
  2. ↑ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. (December 2010). "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect". Journal of Medicinal Chemistry. 53 (23): 8274–86. doi:10.1021/jm101206p. PMC 3150605. PMID 21073191.
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