Α-Acetyldigoxin

α-Acetyldigoxin
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Bioavailability90%(Oral)
Protein binding20–30%
Elimination half-life40h
Identifiers
IUPAC name
  • [6-[6-[ [6-[ [12,14-dihydroxy-10,13-dimethyl-17-
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.024.414
Edit this at Wikidata
Chemical and physical data
FormulaC43H66O15
Molar mass822.986 g·mol−1
3D model (JSmol)
SMILES
  • O=C\1OC/C(=C/1)[C@H]2CC[C@@]8(O)[C@]2(C)[C@H](O)C[C@H]7[C@H]8CC[C@H]6[C@]7(C)CC[C@H](O[C@@H]5O[C@H](C)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@@H](OC(=O)C)C3)C)[C@@H](O)C4)C)[C@@H](O)C5)C6
InChI
  • InChI=1S/C43H66O15/c1-20-38(49)32(55-23(4)44)18-37(52-20)58-40-22(3)54-36(17-31(40)46)57-39-21(2)53-35(16-30(39)45)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(47)42(6)27(10-12-43(28,42)50)24-13-34(48)51-19-24/h13,20-22,25-33,35-40,45-47,49-50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1 checkY
  • Key:HWKJSYYYURVNQU-DXJNJSHLSA-N checkY
  (verify)

α-Acetyldigoxin is a cardiac glycoside. It is an acetyl derivative of digoxin and an isomer of β-acetyldigoxin. It increases the contractility of the heart by its positive inotropic effect on cardiac muscle. The effects of α-acetyldigoxin begin 3–4 hours after administration, and maximize after 6–8 hours. It is prescribed for congestive chronic cardiac failure class II, III and IV.

This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.