Avatrombopag

Avatrombopag
Names
Pronunciationa" va trom' boe pag
Trade namesDoptelet
Other namesAvatrombopag maleate
IUPAC name
  • 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
Clinical data
Drug classThrombopoietin receptor agonist[1]
Main usesLow platelets in chronic liver disease[2][3]
Side effectsFever, abdominal pain, nausea, headache, tiredness, peripheral swelling[2]
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Pregnancy
category
  • US: N (Not classified yet)
    Routes of
    use    		By mouth
    Typical dose40 to 60 mg OD[3]
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa618032
    Legal
    License data
    Legal status
    • US: ℞-only
    • EU: Rx-only
    • In general: ℞ (Prescription only)
    Chemical and physical data
    FormulaC29H34Cl2N6O3S2
    Molar mass649.65 g·mol−1
    3D model (JSmol)
    SMILES
    • C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
    InChI
    • InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38) checkY
    • Key:OFZJKCQENFPZBH-UHFFFAOYSA-N

    Avatrombopag, sold under the brand name Doptelet, is a medication used to treat low platelets in chronic liver disease when an invasive medical procedure is required.[2][3] It is taken by mouth.[1]

    Common side effects include fever, abdominal pain, nausea, headache, tiredness, and peripheral swelling.[2] Other side effects may include blood clots.[2] Use in pregnancy may harm the baby.[2] Safety in pregnancy or breastfeeding is unclear.[1] It is a thrombopoietin receptor agonist, which increases platelet production.[1]

    Avatrombopag was approved for medical use in the United States in 2018 and Europe in 2019.[2][3] In the United Kingdom a course of treatment costs the NHS £640 to £960 as of 2020.[4] In the United States this amount is 3,650 USD to 5,500 USD.[5]

    Medical uses

    Dosage

    It should be started 10 days before the procedure.[3] It is used at a dose of 40 to 60 mg per day, depending on a persons platelets, for 5 days.[2]

    References

    1. 1 2 3 4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1079. ISBN 978-0857114105.
    2. 1 2 3 4 5 6 7 8 "Avatrombopag Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 16 January 2022.
    3. 1 2 3 4 5 "Doptelet EPAR". European Medicines Agency (EMA). 24 April 2019. Archived from the original on 22 May 2020. Retrieved 2 May 2020.
    4. ↑ "Avatrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure". Archived from the original on 17 January 2022. Retrieved 16 January 2022.
    5. ↑ "Doptelet Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 April 2021. Retrieved 16 January 2022.
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