Borrelia miyamotoi

Borrelia miyamotoi
Scientific classification edit
Domain: Bacteria
Phylum: Spirochaetota
Class: Spirochaetia
Order: Spirochaetales
Family: Borreliaceae
Genus: Borrelia
Species:
B. miyamotoi
Binomial name
Borrelia miyamotoi
Fukunaga et al. 1995

Borrelia miyamotoi is a bacterium of the spirochete phylum in the genus Borrelia. A zoonotic organism, B. miyamotoi can infect humans through the bite of several species of hard-shell Ixodes ticks, the same kind of ticks that spread B. burgdorferi, the causative bacterium of Lyme disease. Ixodes ticks are also the primary vector in the spread of babesiosis and anaplasmosis.[1]

B. miyamotoi causes Borrelia miyamotoi disease (BMD) in humans. BMD is a relapsing fever illness that has been reported across the world, often in the same geographic areas where Lyme disease is endemic.[1] Treatment currently follows that of Lyme disease.[2]

Microbiology

History and morphology

B. miyamotoi was discovered in 1995 when it was isolated from a population of Ixodes persulcates ticks on the Japanese island of Hokkaido.[1] The organism was named for Kenji Miyamoto, who initially discovered Borrellia spirochetes in Japan.[3] It was first detected in the United States in 2001.[4]

B. miyamotoi is a gram-negative, anaerobic, obligate parasitic bacterium with a spiraling corkscrew shape.[1][5]

Genetics

The bacterial genome is physically made up of one linear chromosome, twelve linear plasmids, and two circular plasmids, which encode a total of 1362 genes. Four distinct genotypes of B. miyamotoi have been demonstrated based on examples isolated from Asia, Europe, and North America.[2][5]

Borrelia species that cause human disease are classified into two genetic clades, the Lyme borreliosis (LB) clade, and the relapsing fever (RF) clade. B. miyamotoi is a member of the relapsing fever (RF) clade.[5] The glpQ gene and its resulting GlpQ protein are conserved in the RF clade of Borrelia, which makes it possible to distinguish them from LB group Borrellia in testing.[5]

Transmission

Unlike B. burgdoferi, B. miyamotoi exhibits transovarial transmission, whereby the bacterium is passed from an adult tick directly into the eggs of new larvae within the ovaries. This mode of transmission has implications for diagnosis of disease because a very small larva can attach to a human host and go undetected.[1]

Virulence factors

B. myomotoi employs antigenic variation and variable membrane proteins (VMPs) that help it to evade the human immune system.[6] It is also known to evade components of the complement cascade, part of innate immune system, which mounts the initial response to an infection.[2][7]

Disease

Signs and symptoms

BMD presents approximately two weeks after infection with non-specific flu-like symptoms including a relapsing-remitting fever in excess of 40C (104F), malaise, myalgias (muscle pain), arthralgias (joint pain), nausea, vomiting, and headache. Some patients may have elevated liver transaminases, thrombocytopenia, and leukopenia.[1][2][5][6] Cases involving an erythema migrans rash, which is a classic feature of Lyme disease, have been reported, but are believed to likely be the result of co-infection with B. burgdorferi and the development of co-morbid Lyme disease.[2] B. miyamotoi has also demonstrated a slower onset neurological syndrome including meningitis in some immunocompromised patients.[2][5]

Since ticks in all phases of their life cycle, including very small larvae, can transmit the disease to humans, the bite and tick can easily go undetected.[1] B. miyamotoi also transmits faster than B. burgdorfi, often within 24 hours of tick attachment.[1][2]

Reservoirs

Several variations of mice and voles are known rodent reservoirs for B. miyamotoi, including Apodemus spp., Myodes glareolus, and Peromyscus leucopus.[2] There is also some preliminary evidence for various avian and several large animal reservoirs such as wild boar and deer.[2]

Vector

The primary vector for B. miyamotoi transmission is the hard-shell Ixodes tick. Specific species of the tick have been identified in different parts of the world.[1][2][5]

Ixodes species by region
Region Species
China, Japan, Russia Ixodes persulcatus
Japan, Russia Ixodes pavlovski
Southeast Asia Ixodes ovatus
United States Ixodes scapularis
United States (California) Ixodes pacificus
Western Europe Ixodes ricinus

Diagnosis

Partial 16S–23S rRNA intragenic spacer region of Borrelia miyamotoi (450 bp)

No widely available diagnostic test made specifically for B. miyamotoi exists currently.[1]

Polymerase chain reaction (PCR) testing for the 16S ribosomal DNA, fla, or p66 genes have been used in specialized labs.[2][5] PCR for the glpQ gene can be used to rule out Lyme disease since LB clade Borrelia species don't contain it, however a positive test doesn't necessarily indicate B. miyamotoi infection because the gene exists in all RF clade Borrelia species.[1][2][5]

An investigational method of detection involving combined serologic testing for IgG and IgM antibodies against both the GlpQ and VMP proteins has recently shown high sensitivity and specificity.[2][5]

Treatment

No specific evidence-based treatment regimen or protocol currently exists for BMD. Treatments in use are currently similar to those used in Lyme disease. Courses of doxycycline or ceftriaxone have been reported as effective. A general resistance to amoxicillin was noted in one study.[1][2] The Jarisch-Herxheimer reaction has been noted at the start of antibiotic treatment for BMD.[2][8]

History

Borellia miyamotoi disease (BMD) in humans was first described in Russia in 2011, then subsequently in Japan, China, North America, Western Europe, and Asia.[2][5]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 Della-Giustina, David; Duke, Charles; Goldflam, Katja (2021-06-01). "Underrecognized Tickborne Illnesses: Borrelia Miyamotoi and Powassan Virus". Wilderness & Environmental Medicine. 32 (2): 240–246. doi:10.1016/j.wem.2021.01.005. ISSN 1080-6032. PMID 33839017. S2CID 233212517. Archived from the original on 2023-06-30. Retrieved 2023-02-07.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Cutler, Sally; Vayssier-Taussat, Muriel; Estrada-Peña, Agustín; Potkonjak, Aleksandar; Mihalca, Andrei Daniel; Zeller, Hervé (2019-05-02). "A new Borrelia on the block: Borrelia miyamotoi – a human health risk?". Eurosurveillance. 24 (18): 1800170. doi:10.2807/1560-7917.ES.2019.24.18.1800170. ISSN 1560-7917. PMC 6505184. PMID 31064634.
  3. ↑ "Etymologia: Borrelia miyamotoi - Volume 20, Number 8—August 2014 - Emerging Infectious Diseases journal - CDC". doi:10.3201/eid2008.et2008. S2CID 44613963. Archived from the original on 2023-02-05. Retrieved 2023-02-07. {{cite journal}}: Cite journal requires |journal= (help)
  4. ↑ Rodino, Kyle G.; Theel, Elitza S.; Pritt, Bobbi S. (2020-04-01). "Tick-Borne Diseases in the United States". Clinical Chemistry. 66 (4): 537–548. doi:10.1093/clinchem/hvaa040. ISSN 1530-8561. PMID 32232463. Archived from the original on 2023-02-20. Retrieved 2023-02-07.
  5. 1 2 3 4 5 6 7 8 9 10 11 Kubiak, Katarzyna; Szczotko, Magdalena; Dmitryjuk, Małgorzata (2021-01-12). "Borrelia miyamotoi—An Emerging Human Tick-Borne Pathogen in Europe". Microorganisms. 9 (1): 154. doi:10.3390/microorganisms9010154. ISSN 2076-2607. PMC 7827671. PMID 33445492.
  6. 1 2 Talagrand-Reboul, Emilie; Boyer, Pierre H.; Bergström, Sven; Vial, Laurence; Boulanger, Nathalie (2018). "Relapsing Fevers: Neglected Tick-Borne Diseases". Frontiers in Cellular and Infection Microbiology. 8: 98. doi:10.3389/fcimb.2018.00098. PMC 5893795. PMID 29670860. Archived from the original on 2022-02-04. Retrieved 2023-02-07.
  7. ↑ Stone, Brandee L.; Brissette, Catherine A. (2017). "Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi". Frontiers in Immunology. 8: 12. doi:10.3389/fimmu.2017.00012. PMC 5243832. PMID 28154563. Archived from the original on 2022-02-04. Retrieved 2023-02-07.
  8. ↑ Krause, P. J.; Fish, D.; Narasimhan, S.; Barbour, A. G. (2015-07-01). "Borrelia miyamotoi infection in nature and in humans". Clinical Microbiology and Infection. 21 (7): 631–639. doi:10.1016/j.cmi.2015.02.006. ISSN 1198-743X. PMC 4470780. PMID 25700888. Archived from the original on 2023-06-30. Retrieved 2023-02-07.
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