Eosinophilic cellulitis

Eosinophilic cellulitis
Other names: Wells' syndrome, recurrent granulomatous dermatitis with eosinophilia[1]
Initial rash in eosinophilic cellulitis
SpecialtyDermatology
SymptomsPainful, red, raised, warm patches of skin[2]
Usual onsetSudden and recurrent[2]
DurationFew weeks[2]
CausesUnknown[2]
Differential diagnosisVasculitis, cellulitis, anaphylaxis[2][1]
MedicationCorticosteroids, antihistamines[2][1]
PrognosisOften goes away by itself[2]
Frequency~200 documented cases[1]

Eosinophilic cellulitis, also known as Wells' syndrome (not to be confused with Weil's disease), is a skin disease that presents with painful, red, raised, and warm patches of skin.[2] The rash comes on suddenly, lasts for a few weeks, and often repeatedly comes back.[2] Scar formation does not typically occur.[1]

Eosinophilic cellulitis is of unknown cause.[2] It is suspected to be an autoimmune disorder.[2] It may be triggered by bites from insects such as spiders, fleas, or ticks, or from medications or surgery.[2] Diagnosis is made after other potential cases are ruled out.[1] Skin biopsy of the affected areas may show an increased number of eosinophils.[2] Other conditions that may appear similar include cellulitis, contact dermatitis, and severe allergic reactions such as anaphylaxis.[2]

Treatment is often with a corticosteroids.[2] Steroids applied as a cream is generally recommended over the use of steroids by mouth.[3] Antihistamines may be used to help with itchiness.[1] Many times the condition goes away after a few weeks without treatment.[2] The condition is uncommon.[1] It affects both sexes with the same frequency.[2] It was first described by George Crichton Wells in 1971.[4][1]

Signs and symptoms

The presentation of this condition consist of edema, cellulitis, and blistering of the skin[5]

  • Wells syndrome
    Wells syndrome
  • Wells syndrome
    Wells syndrome
  • Wells syndrome
    Wells syndrome

Cause

Eosinophilic cellulitis is of unknown cause.[2] It is suspected to be an autoimmune disorder.[2] It may be triggered by bites from insects such as mosquitos,[6] spiders, fleas, or ticks, or from medications or surgery.[2]

Diagnosis

Histology of a skin biopsy from acute phase eosinophilic cellulitis. Note findings of plentiful tissue eosinophils and flame figures at the deeper corium sections (hematoxylin & eosin, original magnification ×40).

Diagnosis requires ruling out other potential causes.[1] This includes ruling out vasculitis on skin biopsy.[1]

Treatment

Treatment is often with a steroids.[2] This can be either applied as a cream or taken by mouth.[3] As the condition tends to get better on its own taking steroids by mouth should generally only be tried if the rash covers a large area and it does not get better with other measures.[3]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 Weins, AB; Biedermann, T; Weiss, T; Weiss, JM (October 2016). "Wells syndrome". Journal der Deutschen Dermatologischen Gesellschaft. 14 (10): 989–993. doi:10.1111/ddg.13132. PMID 27767278.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 "Familial Eosinophilic Cellulitis - NORD (National Organization for Rare Disorders)". NORD (National Organization for Rare Disorders). 2009. Archived from the original on 4 March 2016. Retrieved 10 April 2017.
  3. 1 2 3 Räßler, F; Lukács, J; Elsner, P (September 2016). "Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review". Journal of the European Academy of Dermatology and Venereology : JEADV. 30 (9): 1465–79. doi:10.1111/jdv.13706. PMID 27357601.
  4. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  5. ↑ "Wells syndrome | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 18 March 2021. Retrieved 15 May 2021.
  6. ↑ Tatsuno K, Fujiyama T, Matsuoka H, Shimauchi T, Ito T, Tokura Y (June 2016). "Clinical categories of exaggerated skin reactions to mosquito bites and their pathophysiology". Journal of Dermatological Science. 82 (3): 145–52. doi:10.1016/j.jdermsci.2016.04.010. PMID 27177994.
Classification
This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.