Glass ionomer cement

Glass ionomer cement
Glass ionomer
Clinical data
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Glass ionomer cement (GIC) is a dental restorative material used as a filling material and luting cement,[1] as well as for attaching braces.[2]

They are based on the reaction of silicate glass-powder (calciumaluminofluorosilicate glass[3]) and polyacrylic acid, an ionomer. Occasionally water is used instead of an acid,[2] altering the properties of the material and its uses.[4] This reaction produces a powdered cement of glass particles surrounded by matrix of fluoride elements and is known chemically as glass polyalkenoate.[5] There are other forms of similar reactions which can take place, for example, when using an aqueous solution of acrylic/itaconic copolymer with tartaric acid, this results in a glass-ionomer in liquid form. An aqueous solution of maleic acid polymer or maleic/acrylic copolymer with tartaric acid can also be used to form a glass-ionomer in liquid form. Tartaric acid plays a significant part in controlling the setting characteristics of the material.[5] Glass-ionomer based hybrids incorporate another dental material, for example resin-modified glass ionomer cements (RMGIC) and compomers (or modified composites).[5]

It is on the World Health Organization's List of Essential Medicines.[6]

Medical use

Glass ionomer cement is primarily used in the prevention of dental caries. This dental material has good adhesive bond properties to tooth structure,[7] allowing it to form a tight seal between the internal structures of the tooth and the surrounding environment. Dental caries is caused by bacterial production of acid during their metabolic actions. The acid produced from this metabolism results in the breakdown of tooth enamel and subsequent inner structures of the tooth, if the disease is not intervened by a dental professional, or if the carious lesion does not arrest and/or the enamel re-mineralises by itself. Glass ionomer cements act as sealants when pits and fissures in the tooth occur and release fluoride to prevent further enamel demineralisation and promote remineralisation. Fluoride can also hinder bacterial growth, by inhibiting their metabolism of ingested sugars in the diet. It does this by inhibiting various metabolic enzymes within the bacteria. This leads to a reduction in the acid produced during the bacteria's digestion of food, preventing a further drop in pH and therefore preventing caries.

The application of glass ionomer sealants to occlusal surfaces of the posterior teeth, reduce dental caries in comparison to not using sealants at all.[8] There is evidence that when using sealants, only 6% of people develop tooth decay over a 2-year period, in comparison to 40% of people when not using a sealant.[8] However, it is recommended that the use of fluoride varnish alongside glass ionomer sealants should be applied in practice to further reduce the risk of secondary dental caries.[9]

Resin-modified glass ionomers

The addition of resin to glass ionomers improves them significantly, allowing them to be more easily mixed and placed.[3] Resin-modified glass ionomers allow equal or higher fluoride release and there is evidence of higher retention, higher strength and lower solubility.[3] Resin-based glass ionomers have two setting reactions: an acid-base setting and a free-radical polymerisation. The free-radical polymerisation is the predominant mode of setting, as it occurs more rapidly than the acid-base mode. Only the material properly activated by light will be optimally cured. The presence of resin protects the cement from water contamination. Due to the shortened working time, it is recommended that placement and shaping of the material occurs as soon as possible after mixing.[5]

Fluoride release and remineralisation

The pattern of fluoride release from glass ionomer cement is characterised by an initial rapid release of appreciable amounts of fluoride, followed by a taper in the release rate over time.[10]  An initial fluoride “burst” effect is desirable to reduce the viability of remaining bacteria in the inner carious dentin, hence, inducing enamel or dentin remineralization.[10]  The constant fluoride release during the following days are attributed to the fluoride ability to diffuse through cement pores and fractures. Thus, continuous small amounts of fluoride surrounding the teeth reduces demineralization of the tooth tissues.[10] A study by Chau et al. shows a negative correlation between acidogenicity of the biofilm and the fluoride release by GIC,[11] suggestive that enough fluoride release may decrease the virulence of cariogenic biofilms.[12]  In addition, Ngo et al. (2006) studied the interaction between demineralised dentine and Fuji IX GP which includes a strontium – containing glass as opposed to the more conventional calcium-based glass in other GICs. A substantial amount of both strontium and fluoride ions was found to cross the interface into the partially demineralised dentine affected by caries.[12] This promoted mineral depositions in these areas where calcium ion levels were low. Hence, this study supports the idea of glass ionomers contributing directly to remineralisation of carious dentine, provided that good seal is achieved with intimate contact between the GIC and partly demineralised dentine. This, then raises a question, “Is glass ionomer cement a suitable material for permanent restorations?” due to the desirable effects of fluoride release by glass ionomer cement.

Primary teeth

Findings of reviews suggested that conventional glass ionomers were not recommended for Class II restorations in primary molars.[13]  This material showed poor anatomical form and marginal integrity, and composite restorations were shown to be more successful than GIC when good moisture control could be achieved.[13]  Resin modified glass ionomer cements (RMGIC) were developed to overcome the limitations of the conventional glass ionomer as a restorative material. A systematic review supports the use of RMGIC in small to moderate sized class II cavities, as they are able to withstand the occlusal forces on primary molars for at least one year.[13]  With their desirable fluoride releasing effect, RMGIC may be considered for Class I and Class II restorations of primary molars in high caries risk population.

Permanent teeth

With regard to permanent teeth, there is insufficient evidence to support the use of RMGIC as long term restorations in permanent teeth. Despite the low number of randomised control trials, a meta- analysis review by Bezerra et al. [2009] reported significantly fewer carious lesions on the margins of glass ionomer restorations in permanent teeth after six years as compared to amalgam restorations.[14]  In addition, adhesive ability and longevity of GIC from a clinical standpoint can be best studied with restoration of non- carious cervical lesions. A systematic review shows GIC has higher retention rates than resin composite in follow up periods of up to 5 years.[15] Unfortunately, reviews for Class II restorations in permanent teeth with glass ionomer cement are scarce with high bias or short study periods. However, a study[16]  [2003] of the compressive strength and the fluoride release was done on 15 commercial fluoride- releasing restorative materials. A negative linear correlation was found between the compressive strength and fluoride release (r2=0.7741), i.e., restorative materials with high fluoride release have lower mechanical properties.[16]

Technique

Glass ionomers are used frequently due to the versatile properties they contain and the relative ease with which they can be used. Prior to procedures, starter materials for glass ionomers are supplied either as a powder and liquid or as a powder mixed with water. A mixed form of these materials can be provided in an encapsulated form.[17]

Preparation of the material should involve following manufacture instructions. A paper pad or cool dry glass slab may be used for mixing the raw materials though it is important to note that the use of the glass slab will retard the reaction and hence increase the working time.[18] The raw materials in liquid and powder form should not be dispensed onto the chosen surface until the mixture is required in the clinical procedure the glass ionomer is being used for, as a prolonged exposure to the atmosphere could interfere with the ratio of chemicals in the liquid. At the stage of mixing, a spatula should be used to rapidly incorporate the powder into the liquid for a duration of 45–60 seconds depending on manufacture instructions and the individual products.[19]

Once mixed together to form a paste, an acid-base reaction occurs which allows the glass ionomer complex to set over a certain period of time and this reaction involves four overlapping stages:

  • Dissolution
  • Gelation
  • Hardening (3–6 min)
  • Maturation (24 hr – 1 yr)

It is important to note that glass ionomers have a long setting time and need protection from the oral environment in order to minimize interference with dissolution and prevent contamination.[20]

The type of application for glass ionomers depends on the cement consistency as varying levels of viscosity from very high viscosity to low viscosity, can determine whether the cement is used as luting agents, orthodontic bracket adhesives, pit and fissure sealants, liners and bases, core build-ups, or intermediate restorations.[18]

The different uses as restorative materials include;

  • Cermets, which are essentially metal reinforced, glass ionomer cements, used to aid in restoring tooth loss as a result of decay or cavities to the tooth surfaces near the gingival margin, or the tooth roots, though cermets can be incorporated at other sites on various teeth, depending on the function required. They maintain adhesion to enamel and dentine and have an identical setting reaction to other glass ionomers. The development of cermets is an attempt to improve the mechanical properties of glass ionomers, particularly brittleness and abrasion resistance by incorporating metals such as silver, tin, gold and titanium. The use of these materials with glass ionomers appears to increase the value of compressive strength and fatigue limit as compared to conventional glass ionomer, however there is no marked difference in the flexural strength and resistance to abrasive wear as compared to glass ionomers.[17][19]
  • Dentine surface treatment, which can be performed with glass ionomer cements as the cement has adhesive characteristics which may be useful when placed in undercut cavities. The surfaces on which the glass cement ionomers are placed would be adequately prepared by removing the precipitated salivary proteins, present from saliva as this would greatly reduce the receptiveness of the glass ionomer cement and dentine surface, to bond formation. A number of different substances can be used to remove this element, such as citric acid, however the most effective substance seems to be polyacrylic acid, which is applied to the tooth surface for 30 seconds before it is washed off. The tooth is then dried to ensure the surface is receptive to bond formation but care is taken to ensure desiccation does not occur.[17][21]
  • Matrix techniques with glass ionomers, which are used to aid in proximal cavity restorations of anterior teeth. Between the teeth that are adjacent to the cavity, the matrix is inserted, commonly before any dentine surface conditioning. Once the material is inserted in excess, the matrix is placed around the tooth root and kept in place with the help of firm digital pressure while the material sets. Once set, the matrix can be carefully removed using a sharp probe or excavator.[17]
  • Fissure sealants, which involve the use of glass ionomers as the materials can be mixed to achieve a certain fluid consistency and viscosity that allows the cement to sink into fissures and pits located in posterior teeth and fill these spaces which pose as a site for caries risk, thereby reducing the risk of caries manifesting.[17][22]
  • Orthodontic brackets, which can involve the use of glass ionomer cements as an adhesive cement that forms strong chemical bonds between the enamel and the many metals which are used in orthodontic brackets such as stainless steel.[21]
  • Fluoride varnishes have been combined with sealant application in the prevention of dental caries. There is low certainty evidence that the combined usage of both increases the overall effectiveness as compared to using fluoride varnish alone.[23][24]

Chemistry

All GICs contain a basic glass and an acidic polymer liquid, which set by an acid-base reaction. The polymer is an ionomer, containing a small proportion – some 5 to 10% – of substituted ionic groups. These allow it to be acid decomposable and clinically set readily.

The glass filler is generally a calcium alumino fluorosilicate powder, which upon reaction with a polyalkenoic acid gives a glass polyalkenoate-glass residue set in an ionised, polycarboxylate matrix.

The acid base setting reaction begins with the mixing of the components. The first phase of the reaction involves dissolution. The acid begins to attack the surface of the glass particles, as well as the adjacent tooth substrate, thus precipitating their outer layers but also neutralising itself. As the pH of the aqueous solution rises, the polyacrylic acid begins to ionise, and becoming negatively charged it sets up a diffusion gradient and helps draw cations out of the glass and dentine. The alkalinity also induces the polymers to dissociate, increasing the viscosity of the aqueous solution.

The second phase is gelation, where as the pH continues to rise and the concentration of the ions in solution to increase, a critical point is reached and insoluble polyacrylates begin to precipitate. These polyanions have carboxylate groups whereby cations bind them, especially Ca2+ in this early phase, as it is the most readily available ion, crosslinking into calcium polyacrylate chains that begin to form a gel matrix, resulting in the initial hard set, within five minutes. Crosslinking, H bonds and physical entanglement of the chains are responsible for gelation. During this phase, the GIC is still vulnerable and must be protected from moisture. If contamination occurs, the chains will degrade and the GIC lose its strength and optical properties. Conversely, dehydration early on will crack the cement and make the surface porous.

Over the next twenty four hours maturation occurs. The less stable calcium polyacrylate chains are progressively replaced by aluminium polyacrylate, allowing the calcium to join the fluoride and phosphate and diffuse into the tooth substrate, forming polysalts, which progressively hydrate to yield a physically stronger matrix.[25]

The incorporation of fluoride delays the reaction, increasing the working time. Other factors are the temperature of the cement, and the powder to liquid ratio – more powder or heat speeding up the reaction.

GICs have good adhesive relations with tooth substrates, uniquely chemically bonding to dentine and, to a lesser extend, to enamel. During initial dissolution, both the glass particles and the hydroxyapatite structure are affected, and thus as the acid is buffered the matrix reforms, chemically welded together at the interface into a calcium phosphate polyalkenoate bond. In addition, the polymer chains are incorporated into both, weaving cross links, and in dentine the collagen fibres also contribute, both linking physically and H-bonding to the GIC salt precipitates. There is also microretention from porosities occurring in the hydroxyapatite.[26]

Works employing non-destructive neutron scattering and terahertz (THz) spectroscopy have evidenced that GIC's developing fracture toughness during setting is related to interfacial THz dynamics, changing atomic cohesion and fluctuating interfacial configurations. Setting of GICs is non-monotonic, characterised by abrupt features, including a glass–polymer coupling point, an early setting point, where decreasing toughness unexpectedly recovers, followed by stress-induced weakening of interfaces. Subsequently, toughness declines asymptotically to long-term fracture test values.[27]

Non-destructive neutron scattering has evidenced GIC setting reactions to be non-monotonic, with eventual fracture toughness dictated by changing atomic cohesion, fluctuating interfacial configurations and interfacial terahertz (THz) dynamics.[27]

History

Dental sealants were first introduced as part of the preventative programme, in the late 1960s, in response to increasing cases of pits and fissures on occlusal surfaces due to caries.[8] This led to glass ionomer cements to be introduced in 1972 by Wilson and Kent as derivative of the silicate cements and the polycarboxylate cements.[5] The glass ionomer cements incorporated the fluoride releasing properties of the silicate cements with the adhesive qualities of polycarboxylate cements.[4] This incorporation allowed the material to be stronger, less soluble and more translucent (and therefore more aesthetic) than its predecessors.[5]

Glass ionomer cements were initially intended to be used for the aesthetic restoration of anterior teeth and were recommended for restoring Class III and Class V cavity preparations.[7] There have now been further developments in the material's composition to improve properties. For example, the addition of metal or resin particles into the sealant is favoured due to the longer working time and the material being less sensitive to moisture during setting.[7]

When glass ionomer cements were first used, they were mainly used for the restoration of abrasion/erosion lesions and as a luting agent for crown and bridge reconstructions. However, this has now been extended to occlusal restorations in deciduous dentition, restoration of proximal lesions and cavity bases and liners.[4] This is made possible by the ever-increasing new formulations of glass ionomer cements.

One of the early commercially successful GICs, employing G338 glass and developed by Wilson and Kent, served purpose as non-load bearing restorative materials. However, this glass resulted in a cement too brittle for use in load-bearing applications such as in molar teeth. The properties of G338 being shown to be related to its phase-composition, specifically the interplay between its three amorphous phases Ca/Na-Al-Si-O, Ca-Al-F and Ca-P-O-F, as characterised by mechanical testing, differential scanning calorimetry (DSC) and X-ray diffraction (XRD),[28] as well as quantum chemical modelling and ab initio molecular dynamics simulations.[29]

Versus resin-based sealants

When the two dental sealants are compared, there has always been a contradiction as to which materials is more effective in caries reduction. Therefore, there are claims against replacing resin-based sealants, the current gold standard, with glass ionomer.[30][31][32]

Advantages

Glass ionomer sealants are thought to prevent caries through a steady fluoride release over a prolonged period and the fissures are more resistant to demineralization, even after the visible loss of sealant material,[8] however, a systemic review found no difference in caries development when GICs was used as a fissure sealing material compared to the conventional resin based sealants, in addition, it has less retention to the tooth structure than the resin based sealants.[33]

These sealants have hydrophilic properties, allowing them to be an alternative of the hydrophobic resin in the generally wet oral cavity. Resin-based sealants are easily destroyed by saliva contamination.

Chemically curable glass ionomer cements are considered safe from allergic reactions but a few have been reported with resin-based materials. Nevertheless, allergic reactions are very rarely associated with both sealants.[8]

Disadvantages

The main disadvantage of glass ionomer sealants or cements has been inadequate retention or simply lack of strength, toughness, and limited wear resistance.[34][35] For instance, due to its poor retention rate, periodic recalls are necessary, even after 6 months, to eventually replace the lost sealant.[8][36] Different methods have been used to address the physical shortcomings of the glass ionomer cements such as thermo-light curing (polymerization),[37][38] or addition of the zirconia, hydroxyapatite, N-vinyl pyrrolidone, N-vinyl caprolactam, and fluoroapatite to reinforce the glass ionomer cements.[39]

References

  1. ↑ Sidhu, SK. (2011). "Glass-ionomer cement restorative materials: A sticky subject?". Australian Dental Journal. 56: 23–30. doi:10.1111/j.1834-7819.2010.01293.x. PMID 21564113.
  2. 1 2 Millett, Declan T.; Glenny, Anne-Marie; Mattick, Rye Cr; Hickman, Joy; Mandall, Nicky A. (2016-10-25). "Adhesives for fixed orthodontic bands". The Cochrane Database of Systematic Reviews. 10 (11): CD004485. doi:10.1002/14651858.CD004485.pub4. ISSN 1469-493X. PMC 6461193. PMID 27779317.
  3. 1 2 3 Sonis, Stephen T. (2003). Dental Secrets (3 ed.). Philadelphia: Hanley & Belfus. p. 158.
  4. 1 2 3 Van Noort, Richard; Barbour, Michele (2013). Introduction to Dental Materials (4 ed.). Edinburgh: Elsevier Health Sciences. pp. 95–106.
  5. 1 2 3 4 5 6 McCabe, John F.; Walls, Angus W.G. (2008). Applied Dental Materials (9 ed.). Oxford, United Kingdom: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd). pp. 284–287.
  6. ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  7. 1 2 3 Anusavice, Kenneth J. (2003). Phillips' Science of Dental Materials (11 ed.). United Kingdom: Elsevier Health Sciences. pp. 471–472.
  8. 1 2 3 4 5 6 Ahovuo-Saloranta, Anneli; Forss, Helena; Walsh, Tanya; Hiiri, Anne; Nordblad, Anne; Mäkelä, Marjukka; Worthington, Helen V (2013-03-28). "Sealants for preventing dental decay in the permanent teeth". In Ahovuo-Saloranta, Anneli (ed.). Cochrane Database of Systematic Reviews. The Cochrane Database of Systematic Reviews. John Wiley & Sons, Ltd. pp. CD001830. doi:10.1002/14651858.cd001830.pub4. PMID 23543512.
  9. ↑ Ahovuo-Saloranta, Anneli; Forss, Helena; Walsh, Tanya; Nordblad, Anne; Mäkelä, Marjukka; Worthington, Helen V. (31 July 2017). "Pit and fissure sealants for preventing dental decay in permanent teeth". The Cochrane Database of Systematic Reviews. 2017 (7): CD001830. doi:10.1002/14651858.CD001830.pub5. ISSN 1469-493X. PMC 6483295. PMID 28759120.
  10. 1 2 3 Mousavinasab, Sayed Mostafa; Meyers, Ian (2009). "Fluoride release by glass ionomer cements, compomer and giomer". Dental Research Journal. 6 (2): 75–81. ISSN 2008-0255. PMC 3075459. PMID 21528035.
  11. ↑ Chau, Ngoc Phuong Thanh; Pandit, Santosh; Cai, Jian-Na; Lee, Min-Ho; Jeon, Jae-Gyu (April 2015). "Relationship between fluoride release rate and anti-cariogenic biofilm activity of glass ionomer cements". Dental Materials. 31 (4): e100–e108. doi:10.1016/j.dental.2014.12.016. PMID 25600801.
  12. 1 2 Glass-Ionomers in dentistry. Sidhu, Sharanbir K. Cham. 2015-10-20. ISBN 978-3-319-22626-2. OCLC 926046900.{{cite book}}: CS1 maint: others (link)
  13. 1 2 3 "American Academy of Paediatric Dentistry". Paediatric Restorative Dentistry. 2019.
  14. ↑ Mickenautsch, S.; Yengopal, V.; Leal, S. C.; Oliveira, L. B.; Bezerra, A. C.; Bönecker, M. (March 2009). "Absence of carious lesions at margins of glass-ionomer and amalgam restorations: a meta- analysis". European Journal of Paediatric Dentistry. 10 (1): 41–46. ISSN 1591-996X. PMID 19364244.
  15. ↑ Boing, T. F.; De Geus, J. L.; Wambier, L. M.; Loguercio, A. D.; Reis, A.; Gomes OMM (2018-10-19). "Are Glass-Ionomer Cement Restorations in Cervical Lesions More Long-Lasting than Resin-based Composite Resins? A Systematic Review and Meta-Analysis". The Journal of Adhesive Dentistry. 20 (5): 435–452. doi:10.3290/j.jad.a41310. ISSN 1461-5185. PMID 30349908.
  16. 1 2 Xu, Xiaoming; Burgess, John O. (June 2003). "Compressive strength, fluoride release and recharge of fluoride-releasing materials". Biomaterials. 24 (14): 2451–2461. doi:10.1016/S0142-9612(02)00638-5. PMID 12695072.
  17. 1 2 3 4 5 McCabe, J. F (2008). Applied dental materials. pp. 254. ISBN 9781405139618.
  18. 1 2 Anusavice, Kenneth J. (2003). Phillips' Science of Dental Materials, Eleventh edition. p. 477. ISBN 978-0-7216-9387-3.
  19. 1 2 Ferracane, Jack L. Materials in Dentistry, Principles and Applications. p. 74.
  20. ↑ Noort, Barbour, Richard van, Michele. Introduction to Dental Materials. pp. 95–98.
  21. 1 2 Smith, Wright, Brown, ., Bernard G. N, Paul S., David. The Clinical Handling of Dental Materials, second edition. p. 226.{{cite book}}: CS1 maint: multiple names: authors list (link)
  22. ↑ Ahovuo-Saloranta, A.; Forss, H.; Walsh, T.; Nordblad, A.; Mäkelä, M.; Worthington, H. V. (2017). "sealants for preventing dental decay in the permanent teeth". The Cochrane Database of Systematic Reviews. 7: CD001830. doi:10.1002/14651858.CD001830.pub5. PMC 6483295. PMID 28759120. Archived from the original on 2017-07-05. Retrieved 2022-08-29.
  23. ↑ Levy, Steven M. (2012-06-01). "Pit-and-fissure sealants are more effective than fluoride varnish in caries prevention on occlusal surfaces". The Journal of Evidence-Based Dental Practice. 12 (2): 74–76. doi:10.1016/j.jebdp.2012.03.007. ISSN 1532-3390. PMID 22726782.
  24. ↑ Kashbour, Wafa; Gupta, Puneet; Worthington, Helen V.; Boyers, Dwayne (November 4, 2020). "Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and adolescents". The Cochrane Database of Systematic Reviews. 11: CD003067. doi:10.1002/14651858.CD003067.pub5. ISSN 1469-493X. PMID 33142363. S2CID 226250967. Archived from the original on May 2, 2022. Retrieved August 29, 2022.
  25. ↑ Gao W.; Smales R.J.; Yip H;K. 2000. Demineralization and remineralization of dentine caries, and the role of glass-ionomer cements. Int Dent J. Feb;50(1):51-6.
  26. ↑ Yilmaz, Y. et al. 2005. The influence of various conditioning agents on the interdiffusion zone and microleakage of a glass ionomer cement with a high viscosity in primary teeth. Journal of Operative Dentistry, 30:1 105-113.
  27. 1 2 Tian, Kun V.; Yang, Bin; Yue, Yuanzheng; Bowron, Daniel T.; Mayers, Jerry; Donnan, Robert S.; Dobó-Nagy, Csaba; Nicholson, John W.; Fang, De-Cai; Greer, A. Lindsay; Chass, Gregory A.; Greaves, G. Neville (2015-11-09). "Atomic and vibrational origins of mechanical toughness in bioactive cement during setting". Nature Communications. 6 (8631): 8631. Bibcode:2015NatCo...6.8631T. doi:10.1038/ncomms9631. ISSN 2041-1723. PMC 4659834. PMID 26548704.
  28. ↑ Pedersen, Malene T.; Tian, Kun V.; Dobó-Nagy, Csaba; Chass, Gregory A.; Greaves, G. Neville; Yue, Yuanzheng (2015-05-01). "Phase separation in an ionomer glass: Insight from calorimetry and phase transitions". Journal of Non-Crystalline Solids. 415: 24–29. Bibcode:2015JNCS..415...24P. doi:10.1016/j.jnoncrysol.2015.02.012. ISSN 0022-3093.
  29. ↑ Tian, Kun V.; Chass, Gregory A.; Di Tommaso, Devis (2016). "Simulations reveal the role of composition into the atomic-level flexibility of bioactive glass cements". Physical Chemistry Chemical Physics. 18 (2): 837–845. Bibcode:2016PCCP...18..837T. doi:10.1039/C5CP05650K. ISSN 1463-9076. PMID 26646505. Archived from the original on 2021-06-13. Retrieved 2022-08-29.
  30. ↑ Niederman, Richard (2010-03-01). "Glass ionomer and resin-based fissure sealants – equally effective?". Evidence-Based Dentistry. 11 (1): 10. doi:10.1038/sj.ebd.6400700. ISSN 1462-0049. PMID 20348889. S2CID 2099832.
  31. ↑ Mickenautsch, Steffen; Yengopal, Veerasamy (2011-01-28). "Caries-preventive effect of glass ionomer and resin-based fissure sealants on permanent teeth: An update of systematic review evidence". BMC Research Notes. 4: 22. doi:10.1186/1756-0500-4-22. ISSN 1756-0500. PMC 3041989. PMID 21276215.
  32. ↑ Mickenautsch, Steffen; Yengopal, Veerasamy (2016-01-01). "Caries-Preventive Effect of High-Viscosity Glass Ionomer and Resin-Based Fissure Sealants on Permanent Teeth: A Systematic Review of Clinical Trials". PLOS ONE. 11 (1): e0146512. Bibcode:2016PLoSO..1146512M. doi:10.1371/journal.pone.0146512. ISSN 1932-6203. PMC 4723148. PMID 26799812.
  33. ↑ Alirezaei, Mehrnoush; Bagherian, Ali; Sarraf Shirazi, Alireza (May 2018). "Glass ionomer cements as fissure sealing materials: yes or no?". The Journal of the American Dental Association. 149 (7): 640–649.e9. doi:10.1016/j.adaj.2018.02.001. ISSN 0002-8177. PMID 29735163. S2CID 13681986. Archived from the original on 2019-12-16. Retrieved 2022-08-29.
  34. ↑ Lang O, Kohidai L, Kohidai Z, Dobo-Nagy C, Csomo KB, Lajko M, Mozes M, Keki S, Deak G, Tian KV, Gresz V (2019). "Cell physiological effects of glass ionomer cements on fibroblast cells". Toxicology in Vitro. 61 (104627): 104627. doi:10.1016/j.tiv.2019.104627. ISSN 0887-2333. PMID 31419507. S2CID 201042310.
  35. ↑ Moshaverinia M, Borzabadi-Farahani A, Sameni A, Moshaverinia A, Ansari S (2016). "Effects of incorporation of nano-fluorapatite particles on microhardness, fluoride releasing properties, and biocompatibility of a conventional glass ionomer cement (GIC)". Dent Mater J. 35 (5): 817–821. doi:10.4012/dmj.2015-437. PMID 27725520.
  36. ↑ Baseggio, Wagner; Naufel, Fabiana Scarparo; Davidoff, Denise César de Oliveira; Nahsan, Flávia Pardo Salata; Flury, Simon; Rodrigues, Jonas Almeida (2010-01-01). "Caries-preventive efficacy and retention of a resin-modified glass ionomer cement and a resin-based fissure sealant: a 3-year split-mouth randomised clinical trial". Oral Health & Preventive Dentistry. 8 (3): 261–268. ISSN 1602-1622. PMID 20848004.
  37. ↑ Gavic L, Gorseta K, Borzabadi-Farahani A, Tadin A, Glavina D, van Duinen RN, Lynch E (2016). "Influence of Thermo-Light Curing with Dental Light-Curing Units on the Microhardness of Glass-Ionomer Cements". Int J Periodontics Restorative Dent. 36 (3): 425–30. doi:10.11607/prd.2405. PMID 27100813.
  38. ↑ Gorseta K, Borzabadi-Farahani A, Moshaverinia A, Glavina D, Lynch E (2017). "Effect of different thermo-light polymerization on flexural strength of two glass ionomer cements and a glass carbomer cement". J Prosthet Dent. 118 (1): 102–107. doi:10.1016/j.prosdent.2016.09.019. PMID 27914669. S2CID 28734117.
  39. ↑ Rajabzadeh G, Salehi S, Nemati A, Tavakoli R, Solati Hashjin M (2014). "Enhancing glass ionomer cement features by using the HA/YSZ nanocomposite: A feed forward neural network modelling". J Mech Behav Biomed Mater. 29: 317–27. doi:10.1016/j.jmbbm.2013.07.025. PMID 24140732.


Further reading

  • Anusavice, Kenneth J.; Ralph W. Phillips; Chiayi Shen; H. Ralph Rawls (2013). Phillips' Science of Dental Materials (12th ed.). St. Louis, Mo.: Elsevier/Saunders. ISBN 978-1-4377-2418-9. OCLC 785080357.
  • McCabe, John F.; Angus W. G. Walls (2008). Applied Dental Materials (9th ed.). Oxford, UK: Blackwell Publishing. ISBN 978-1-4051-3961-8. OCLC 180080871. Retrieved 28 March 2013.
  • Van Noort, Richard (2013). "2.3 Glass-ionomer cements and resin-modified glass-ionomer cements". An Introduction to Dental Materials (4th ed.). London: Elsevier/Mosby. pp. 95–106. ISBN 978-0-7234-3659-1. OCLC 821697096.
  • Powers, John M.; John C. Wataha (2013). Dental Materials: Properties and Manipulation (10th ed.). St. Louis, Mo.: Elsevier/Mosby. ISBN 978-0-323-07836-8. OCLC 794161326.
  • Wilson, A. D.; J. W. Nicholson (2005) [1993]. "5.9 Glass polyalkenoate (glass-ionomer) cement". Acid-Base Cements: Their Biomedical and Industrial Applications. Chemistry of Solid State Materials 3 (reprint ed.). Cambridge, UK: Cambridge University Press. pp. 116–196. ISBN 978-0-521-67549-9. OCLC 749544621. Retrieved 28 March 2013.
  • Wilson, Alan D.; John W. McLean (1988). Glass-ionomer Cement. Chicago: Quintessence Publishing Company. ISBN 978-0-86715-200-5. OCLC 17300425.
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