Heat-based contraception

An alternative male contraceptive method involves heating the testicles so that they cannot produce sperm. Sperm are best produced at a temperature slightly below body temperature. The muscles around a male's scrotum involuntarily tighten if the man's body temperature drops, and they loosen, allowing the testes to hang, if the body temperature rises. This is the body's way of keeping the sperm at an ideal temperature. This means that sperm production can be disrupted with increased temperature.[1] Some suggest exposure to high temperatures (116 °F equal to 47 °C) can affect infertility for months.[2]

Male thermal contraceptive methods (MTC) derive their effectiveness from the alteration of the thermoregulatory function of the scrotum.[3] When this function is altered – by wearing tight underwear,[4] being exposed to a high outside temperature, or by suffering from a fever –, fertility may be impaired.

Methods used include hot water applied to the scrotum, heat generated by ultrasound, and artificial cryptorchidism (holding the testicles inside the abdomen) using specialized briefs. One of the initial experiments resulted in partial infertility lasting more than four years.[5] Initial experiments suggest it is effective and safe, though there have not been long-term studies to determine if it has any side effects on the body after reversal.

History

The deleterious effect of hyperthermia on male fertility has been known since ancient times. But it is from the 19th century onwards that the scientific community started to carry out research to better understand the phenomenon.

In the 1930s, physician Marthe Voegeli[6] explored the role of heat in male sterilization. She conducted experiments on the relationship between heat and spermatogenesis. She found that exposing the testicles to high temperatures in hot baths altered fertility. Sperm concentrations in the volunteers decreased so much so that they were considered infertile. She was the first scientist to popularize this alternative method of contraception for men.

The thermal dependence of spermatogenesis was confirmed in various studies carried out between 1950 and 1970 by Doctors Watanabe and Robinson.[7][8][9]

The effect of temperature was first studied with external processes such as hot baths or saunas with temperatures above 40 °C over short periods of exposure.[10][11]

A history of testicular descent problems (cryptorchidism) or professional practices that lead to elevated scrotal temperature and even fever are identified as factors that are prone to reduce fertility.[12] Studies have been carried out with daily exposure of the testicles to less intense heat, around 37 °C, a temperature that is close to that of the body.[13][14]

How it works

The production of sperm can be disrupted with a rise in temperature.[15]

Thermal methods involve heating the testicles so that sperm production is slowed down. The spermatozoa are thus produced at a slightly lower temperature than that of the body, 1 to 2 °C below 37 °C.

The cremaster muscle covers the testicles. It works involuntarily. Its role is to bring the testicles down if the body temperature rises or to raise them if the body temperature drops. This process allows it to regulate the temperature of the testicles and to keep it several degrees lower than that of the body in order to enable an ideal spermatogenesis.[16][17]

Other effects have also been observed, such as a decrease in motility and an alteration in the morphological characteristics of the spermatozoa that are produced.[17][18][19][20]

Some suggest that exposure to high temperatures (47 °C) can affect fertility for months.[3]

Efficiency

Thermal methods do not cause azoospermia, but a reduction of the spermatozoa[21] below the contraceptive threshold considered to be effective.

This contraceptive threshold was defined in 2007 for male thermal, chemical and hormonal contraception methods. It corresponds to 1 million spermatozoa per milliliter per ejaculate.[22][23][24]

The only method that has been tested on enough volunteers to establish that the effectiveness of thermal male contraception is satisfactory is the artificial cryptorchidism method with testicular ascent using a specific device. During the clinical studies, 50 couples were followed over 537 cycles of pregnancy. Only one resulted in a pregnancy due to a misuse of the technique. The Pearl Index would therefore be less than 0.5 and this contraception method can be considered effective according to the standards of the World Health Organisation (WHO).

Adverse effects

The maximum limit of exposure to heat is around 45 °C, which causes the coagulation of intracellular proteins on living cells. However, exposure above 41 °C for short periods of time may be used, as has been the case for scientific studies on the effect of hot baths.[25]

In the case of artificial cryptorchidism or thermal insulation of the testicles, the use of a temperature close to that of the body (37 °C)  has made it possible to increase the time of exposure in order to slow down the spermatogenesis process over longer periods, 4 years in a row at most. To date, only a decrease in testicular volume by a few percents has been observed during the contraceptive period. There is no evidence of an increased risk of testicular torsion. However, it has been shown that the nuclear quality of the spermatozoa was altered during the phase of inhibition of the spermatogenesis, but that this was reversible 3 months after the subject stops practicing artificial cryptorchidism.[26] This finding should be taken into account when using this contraception method, during the inhibition phase and for 3 months after treatment discontinuation.[23]

Methods

Hot baths

Within a few months of daily exposure, the number of spermatozoa drops provided the temperature is higher than that of the body: 38 to 46 °C instead of 37 °C.[7][9][11][15][10][27][28][29]

Artificial cryptorchidism

The principle of artificial cryptorchidism or male thermal contraception[30] with testicle lifting[31][32] is simple.

Warming the testicles with body heat by keeping them in the inguinal sack for several hours a day reduces sperm production below the contraceptive threshold of 1 million/ml.[7][18][20][33][34][35][14][26]

Knowledge of the thermal dependence of spermatogenesis dates back to 1941.[10] However, it was not until 50 years later, in 1991, that the first study  reporting the contraceptive effect of heat on men was published: andrologists Roger Mieusset and Jean-Claude Soufir were the first to get results with the artificial cryptorchidism method[3] (testicles held inside the inguinal sack) with the use of suited devices.

Thermal insulation of the testis

A surgical intervention causes the testicles to be held in the inguinal sack.[33]

Heating devices

Wearing a device that presses the man's testicles against his body on a daily basis can raise their temperature by 2 °C and thus slow down sperm production.[36] To be effective, the device must be worn daily (approximately 15 hours per day) for at least 3 months, which is equivalent to the sperm's life cycle. This allows the contraceptive threshold of one million per millilitre of sperm to be temporarily reached (compared to an average of 15 to 60 million).[37] Practitioners should do pre- and post-usage testing to check their sperm counts.[37]

Various techniques are considered, such as an insulating bag with heating elements in contact with the scrotum.[38]

Heating underwear

The heating briefs are one of the available devices. This method was invented and is prescribed by Doctor Mieusset at the University Hospital of Toulouse.[39] In 2019, a French news channel reported that "only about twenty men were wearing this contraceptive garment in France".[36] It is not sold on the market and a poorly handcrafted design can cause discomfort or irritation.[39] Other "do-it-yourself" models called "jock-strap" or "bra" also exist.[40]

Silicone ring

Another available device is the silicone ring. Invented and patented by Maxime Labrit, a French nurse,[37] it is available for purchase on the Internet for a few dozen euros.[37]

Ultrasounds

One method under investigation is ultrasound, which involves the application of high-frequency sound waves to animal tissue, which in turn absorb the sound waves’ energy as heat. The possibility for ultrasound's use for contraception is based on the idea that briefly heating the testes can halt sperm production, leading to temporary infertility for about six months. Additionally, ultrasound could affect cells’ absorption rates of ions, which itself could create an environment unfavorable to spermatogenesis. Its extremely localized effects on animal tissues make ultrasound an attractive candidate for research, but so far studies have only been performed on non-human animals, such as dogs.[16]

Notes and References

  1. ↑ Kandeel, F. R.; Swerdloff R. S. (Jan 1988). "Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception". Fertil Steril. 49 (1): 1–23. doi:10.1016/S0015-0282(16)59640-X. PMID 3275550.
  2. ↑ Voegeli, Martha M.D. "Data on the thermic method for temporary male sterilization (1954)". Retrieved 14 January 2012.
  3. 1 2 3 « Contraceptions masculines non déférentielles : revue de la littérature | Urofrance » [archive], on www.urofrance.org (consulted on 19 March 2018).
  4. ↑ Schill, Wolf-Bernhard, Comhaire, Frank H., Hargreave, Timothy B., Andrology for the Clinician, Springer, 2006.https://www.springer.com/gp/book/9783540231714
  5. ↑ "Heat Methods". International Male Contraception Coalition. Retrieved 2015-02-17.
  6. ↑ « Contraception masculine : par la chaleur - La Santé des Femmes et Style de Vie », La Santé des Femmes et Style de Vie, 20 janvier 2015 (read online [archive], consulted on 19 March 2018).
  7. 1 2 3 Watanabe A. The effect of heat on human spermatogenesis. Kyushu J Med Sci.1959;10:101–117.
  8. ↑ Robinson D, Rock J, Menkin MF. Control of human spermatogenesis by induced changes of intrascrotal temperature. J Am Med Ass. 1968;204:80–87.
  9. 1 2 Rock J, Robinson D. Effect of induced intrascrotal hyperthermia on testicular function in man. Am J Obstet Gynec. 1965;93:793–801.
  10. 1 2 3 Robert S. Hotchkiss et John Macleod, "The effect of hyperpyrexia upon spermatozoa counts in men", Endocrinology, vol. 28, no 5, 1er mai 1941, p. 780–784 (ISSN 0013-7227, DOI 10.1210/endo-28-5-780, read online [archive], consulted on 22 February 2019).
  11. 1 2 Brown-Woodman PDC, Post EJ, Gasc GC, White IG. The effect of a single sauna exposure on spermatozoa. Arch Androl. 1984;12:9–15.
  12. ↑ « Chapitre 02 - Stérilité du couple : conduite de la première consultation | Urofrance » [archive], on www.urofrance.org (consulted on 19 March 2018)
  13. ↑ Robinson D, Rock J. Intrascrotal hyperthermia induced by scrotal insulation: effect on spermatogenesis. Obstet Gynecol. 1967;2:217–23.
  14. 1 2 Wang C, McDonald V, Leung A, Superlano L, Berman N, Hull L, et al. Effect of increased scrotal temperature on sperm production in normal men. Fertil Steril. 1997;68(2):334–339.
  15. 1 2 F. R. Kandeel et Swerdloff R. S.,"Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception", Fertil Steril, vol. 49, no 1, janvier 1988, p. 1–23 (PMID 3275550).
  16. 1 2 "Expanding Options for Male Contraception". Planned Parenthood Advocates of Arizona. 2011-08-08. Retrieved 2012-03-28.
  17. 1 2 R. Mieusset, « Cryptorchidie et température testiculaire », Andrologie, 1995, p. 317-325 (read online [archive]).
  18. 1 2 Mieusset R, Bujan L, Mansat A, Pontonnier F, Grandjean H. Hyperthermia and human spermatogenesis: enhancement of the inhibitory effect obtained by ‘artificial cryptorchidism’. Int J Androl. 1987;10:571–580.
  19. ↑ Mieusset R, Bujan L, Mansat A, Pontonnier F, Grandjean H. Effect of artificial cryptorchidism on sperm morphology. Fertil Steril. 1987;47:150–155.
  20. 1 2 Shafik A. Testicular suspension as a method of male contraception: technique and results. Adv Contr Deliv Syst. 1991;VII:269–279.
  21. ↑ « Contraceptions masculines non déférentielles : revue de la littérature | Urofrance » [archive], sur www.urofrance.org (consulted on 19 March 2018).
  22. ↑ World Health Organization Task Force on Methods for the Regu- lation of Male Fertility [archive], Gui-Yuan Z, Guo-Zhu L, et al. Contraceptive efficacy of testosterone-induced azoospermia in normal men. Lancet 1990;336:955-959.
  23. 1 2 Jean-Claude Soufir, "Hormonal, chemical and thermal inhibition of spermatogenesis: contribution of French teams to international data with the aim of developing male contraception in France", Basic and Clinical Andrology, vol. 27, 13 janvier 2017, p. 3 (ISSN 2051-4190, DOI 10.1186/s12610-016-0047-2, read online [archive], consulted on 19 March 2018)
  24. ↑ « Contraception masculine : l'avenir est dans le slip… chauffant », ladepeche.fr, 12 January 2018 (read online [archive], consulted on 19 March 2018).
  25. ↑ « Chapitre 42 - La chaleur et le froid » [archive], on www.ilocis.org (consulted on 28 March 2018).
  26. 1 2 Ahmad G, Moinard N, Lamare C, Mieusset R, Bujan L. Mild testicular and epididymal hyperthermia alters sperm chromatin integrity in men. Fertil Steril. 2012;97:546–553.
  27. ↑ Procope BJ. Effect of repeated increase of body temperature on human sperm cells. Int J Fertil. 1965;10:333–339.
  28. ↑ MIEUSSET R., BUJAN L. : Testicular heating and its possible contributions to male infertility : a review. Int. J. Androl., 1995 ; 18 : 169-184.
  29. ↑ Zhu H, Cui Y, Xie J, Chen L, Chen X, Guo X, et al. Proteomic analysis of testis biopsies in men treated with transient scrotal hyperthermia reveals the potential targets for contraceptive development. Proteomics. 2010;10:3480–3493.
  30. ↑ « Contraceptions masculines non déférentielles : revue de la littérature | Urofrance » [archive], on www.urofrance.org (consulted on 1 March 2019).
  31. ↑ R. Mieusset, L. Bujan, A. Mansat et F. Pontonnier, « Hyperthermie scrotale et infécondité masculine », Progrès en Urologie, 1992, p. 31-36 (read online [archive]).
  32. ↑ Jean-Claude Soufir et Roger Mieusset, « Guide pratique d’une contraception masculine hormonale ou thermique », Andrologie, vol. 22, no 3, 2012, p. 211–215 (DOI 10.1007/s12610-012-0192-1, read online [archive]).
  33. 1 2 SHAFIK A. : Contraceptive efficacy of polyester-induced azoospermia in normal men. Contraception, 1992 ; 45 : 439-451.
  34. ↑ MIEUSSET R., BUJAN L. : The potential of mild testicular heating as a safe, effective and reversible contraceptive method for men. Int. J. Androl., 1994 ; 17 : 186-191.
  35. ↑ Moeloek N. Polyester sling scrotal cover induces oligozoospermia in normal Indonesian men. Med J Indones. 1995;4:225–230.
  36. 1 2 Charlotte Anglade, « Contraception masculine : Erwan, 38 ans, porte-étendard du "slip chauffant" » [archive], on lci.fr, 26 September 2019 (consulted on 24 May 2020).
  37. 1 2 3 4 Juliette Pitisci, « Contraception masculine : connaissez-vous le slip chauffant ? » [archive], on rtbf.be, 18 January 2020 (consulted on 24 May 2020).
  38. ↑ Wayne T. Walston, "Male contraceptive device", WIPO, 5 septembre 1990 (read online [archive], consulted on 19 March 2018).
  39. 1 2 Louise Pluyaud, « La contraception, c’est aussi une histoire d’hommes » [archive], on TV5MONDE, 2 October 2015 (consulted on 1 June 2020)
  40. ↑ Association pour la recherche et le développement de la contraception masculine, « Méthode thermique » [archive] (consulted on 24 January 2021)

See also

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