Naphazoline/pheniramine
| Combination of | |
|---|---|
| Pheniramine | Antihistamine |
| Names | |
| Trade names | Naphcon-A, Opcon-A, Visine-A, others |
| Clinical data | |
| WHO AWaRe | UnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽ |
| Pregnancy category |
|
| Routes of use | Eye drop |
| Defined daily dose | not established[1] |
| External links | |
| AHFS/Drugs.com | Multum Consumer Information |
| Legal | |
| Legal status |
|
Naphazoline/pheniramine, sold under the brand name Naphcon-A among others, is a combination eye drop used to help the symptoms of allergic conjunctivitis such as from hay fever.[2] It contains naphazoline and pheniramine.[2][3] It is used as an eye drop.[3] Use is not recommended for more than three days.[4]
Side effects may include allergic reactions, eye pain, and dilated pupils.[2][5][4] It is unclear if use in pregnancy is safe.[3] Nephazoline works by resulting in constriction of blood vessels thus decreasing redness well pheniramine works by blocking the effects of histamine to stop itching.[3]
The combination was approved for medical use in the United States in 1994.[6][7][3] It is available over the counter.[6][7][2] In 2017, it was the 203rd most commonly prescribed medication in the United States, with more than two million prescriptions.[8][7]
Medical use
It is administered topically with one to two drops applied to the affected eye(s) up to four times daily.[2]
Dosage
The defined daily dose is not established[1]
Side effects
- Pupils may become enlarged temporarily
- Overuse may cause more redness
- Those with heart disease, high blood pressure, narrow angle glaucoma or who have urination trouble are discouraged from using the product
- It is recommended to remove contact lenses before use. Use with contact lenses can lead to reduced oxygenation of the underlying cornea
- If infants or children accidentally ingest the drops, it may lead to coma and significant reduction in body temperature. If such ingestion occurs, immediately calling a poison control center is recommended[2]
Society and culture
Cost
In 2017, it was the 203rd most commonly prescribed medication in the United States, with more than two million prescriptions.[8][7]
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Naphazoline/pheniramine costs (US).svg.png.webp)
Naphazoline/pheniramine prescriptions (US)
References
- 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 9 September 2020.
- 1 2 3 4 5 6 "Naphcon A- naphazoline hydrochloride and pheniramine maleate solution/ drops". DailyMed. 16 September 2019. Archived from the original on 28 August 2021. Retrieved 10 August 2020.
- 1 2 3 4 5 "Naphazoline and pheniramine ophthalmic Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
- 1 2 Kizior, Robert J.; Hodgson, Barbara B. (2014). Saunders Nursing Drug Handbook 2015 - E-Book. Elsevier Health Sciences. p. 163. ISBN 9780323280181. Archived from the original on 2020-04-16. Retrieved 2019-04-19.
- ↑ "Naphazoline/pheniramine ophthalmic Side Effects in Detail". Drugs.com. Archived from the original on 19 April 2019. Retrieved 19 April 2019.
- 1 2 "Naphcon-A: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Archived from the original on 22 September 2020. Retrieved 19 April 2020.
- 1 2 3 4 "Naphazoline Hydrochloride; Pheniramine Maleate - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
- 1 2 "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.