Pustulosis palmaris et plantaris

Pustulosis palmaris et plantaris
Other names: Pustulosis of palms and soles,[1] Palmoplantar pustulosis, Persistent palmoplantar pustulosis, Pustular psoriasis of the Barber type, and Pustular psoriasis of the extremities
Pustulosis palmaris et plantaris
SpecialtyDermatology
Risk factorsSAPHO syndrome

Pustulosis palmaris et plantaris is a chronic recurrent type of localized pustular psoriasis on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils.[2]: 411, 628 [3]

It can occur as part of the SAPHO syndrome.[4]

Treatment

Systematic reviews show evidence to support the use of systemic retinoids alone and in combination with photochemotherapy to improve symptoms of chronic palmoplantar pustulosis, with a combination more effective than one alone. There is also evidence to support topical steroids under hydrocolloid occlusion dressings, low dose ciclosporin, tetracyclines, and Grenz-Ray Therapy. There is no evidence to support the use of hydroxyurea in chronic palmoplantar pustulosis.[5]

Treatment with guselkumab, an anti–interleukin 23 monoclonal antibody has shown a decrease in the size of the area affected and severity.[6]

Additional images

  • Palmoplantar pustulosis
    Palmoplantar pustulosis
  • Palmoplantar pustulosis
    Palmoplantar pustulosis
  • Palmoplantar pustulosis
    Palmoplantar pustulosis

See also

References

  1. ↑ Rapini RP, Bolognia JL, Jorizzo JL (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ↑ Freedberg IM, Fitzpatrick TB (2003). Fitzpatrick's Dermatology in General Medicine (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. ↑ James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "10. Seborrheic dermatitis, psoriasis, recalcitrant palmopustular eruptions, pustular dermatitis, and erythroderma". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. pp. 203–204. ISBN 978-0-323-54753-6. Archived from the original on 2022-06-04. Retrieved 2022-06-02.
  4. ↑ Matzaroglou C, Velissaris D, Karageorgos A, Marangos M, Panagiotopoulos E, Karanikolas M (November 2009). "SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature". The Open Orthopaedics Journal. 3: 100–6. doi:10.2174/1874325000903010100. PMC 2790148. PMID 19997538.
  5. ↑ Chalmers, Robert; Hollis, Sally; Leonardi-Bee, Jo; Griffiths, Christopher EM; Marsland Bsc MRCP, Alexander (2006-01-25). "Interventions for chronic palmoplantar pustulosis". Cochrane Database of Systematic Reviews (1): CD001433. doi:10.1002/14651858.cd001433.pub2. ISSN 1465-1858. PMID 16437433.
  6. ↑ Terui T, Kobayashi S, Okubo Y, Murakami M, Zheng R, Morishima H, et al. (July 2019). "Efficacy and Safety of Guselkumab in Japanese Patients With Palmoplantar Pustulosis: A Phase 3 Randomized Clinical Trial". JAMA Dermatology. 155 (10): 1153. doi:10.1001/jamadermatol.2019.1394. PMC 6613288. PMID 31268476.
Classification
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