Promegakaryocyte

Promegakaryocyte

A promegakaryocyte is a precursor cell for a megakaryocyte. It arises from a megakaryoblast, into a promegakaryocyte and then into a megakaryocyte, which will eventually break off and become a platelet.[1]

The developmental stages of the megakaryocyte are: CFU-Me (pluripotential hemopoietic stem cell or hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte.

When the megakaryoblast matures into the promegakaryocyte, it undergoes endoreduplication[2] and forms a promegakaryocyte which has multiple nuclei, azurophilic granules, and a basophilic cytoplasm.[3] The promegakaryocyte has rotary motion, but no forward migration.[4]

Promegakaryocytes and other precursor cells to megakaryocytes arise from pluripotential hematopoietic progenitors.[5] The megakaryoblast is then produced, followed by the promegakaryocyte, the granular megakaryocyte, and then the mature megakaryocyte.[6] When it is in it's promegakaryocyte stage, it is considered an undifferentiated cell. [7]

Megakaryocyte pieces will eventually break off and begin circulating the body as platelets. Platelets are very important because of their role in blood clotting, immune response, and the formation of new blood vessels.[8]

References

  1. ↑ Betts JG, Desaix P, Johnson E, Johnson JE, Korol O, Kruse D, Poe B (2013). Anatomy & physiology. Houston, Texas. ISBN 978-1-947172-04-3. OCLC 898069394.
  2. ↑ Khurana I (November 20, 2009). Textbook of Human Physiology for Dental Students. Elsevier India. p. 141. ISBN 8131205924.
  3. ↑ Rozenberg G (December 19, 2002). Microscopic Haematology: A Practical Guide for the Laboratory (2nd ed.). CRC Press. p. 95. ISBN 1841842338.
  4. ↑ Hiraki K, Ofuji T, Kobayashi T, Sunami H, Awai K (January 31, 1956). "On the function of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombocytopenic Purpura and in Normal Adult". Acta Medicinae Okayama. 10 (2): 57–61. Retrieved July 21, 2017.
  5. ↑ Michelson AD (2007). Platelets (2nd ed.). Amsterdam: Academic Press/Elsevier. ISBN 978-0-12-369367-9. OCLC 162572838.
  6. ↑ Stiff PJ (1990), Walker HK, Hall WD, Hurst JW (eds.), "Platelets", Clinical Methods: The History, Physical, and Laboratory Examinations (3rd ed.), Boston: Butterworths, ISBN 978-0-409-90077-4, PMID 21250105, retrieved 2021-10-13
  7. ↑ Lee YS, Kwak MK, Moon SA, Choi YJ, Baek JE, Park SY, et al. (February 2020). "Regulation of bone metabolism by megakaryocytes in a paracrine manner". Scientific Reports. 10 (1): 2277. doi:10.1038/s41598-020-59250-6. PMC 7010738. PMID 32042021.
  8. ↑ Wilcox DA (March 2016). "Megakaryocyte- and megakaryocyte precursor-related gene therapies". Blood. 127 (10): 1260–1268. doi:10.1182/blood-2015-07-607937. PMC 4786835. PMID 26787735.
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