Sodium calcium edetate

Sodium calcium edetate
Names
Trade namesCalcium disodium versenate, others
Other namesedetate calcium disodium, sodium calcium edetate
IUPAC name
  • Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
Clinical data
Drug classChelating agent
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: B (No risk in non-human studies)
    Routes of
    use    		IV, IM
    Defined daily dosenot established[1]
    External links
    AHFS/Drugs.comMonograph
    Chemical and physical data
    FormulaC10H12CaN2Na2O8
    Molar mass374.270 g·mol−1
    3D model (JSmol)
    SMILES
    • C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
    InChI
    • InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
    • Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J

    Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning.[2] This includes short term and long term lead poisoning.[3] For lead encephalopathy it is typically used together with dimercaprol.[3] It does not appear to be useful for tetraethyllead toxicity.[3] It is given by slow injection into a vein or into a muscle.[2]

    Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3] Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[4] It works by binding a number of heavy metals which allows them to leave the body in the urine.[3]

    Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] In the United States a course of treatment costs 50 to 100 USD as of 2015.[6] Edetate disodium is a different formulation which does not have the same effects.[3]

    Uses

    Medical

    Sodium calcium edetate's primarily use is to treat lead poisoning,[2] for which it is an alternative to succimer.[3] It is given by slow injection into a vein or into a muscle.[2]

    For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[3] It may also be used to treat plutonium poisoning.[7] It does not appear to be useful for poisoning by tetra-ethyl lead.[3]

    Dosage

    The defined daily dose is not established[1]

    Chelation agent

    Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[8] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[3]

    Edetate disodium is a different formulation which does not have the same effects.[3]

    Side effects

    Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3]

    History

    Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines.[9] As of 2015 in the United States, a course of treatment costs US$50 to US$100.[6]

    References

    1. 1 2 "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 13 September 2020.
    2. 1 2 3 4 5 6 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 January 2017.
    3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
    4. ↑ Kasture, Dr A. V. (2008). Pharmaceutical Chemistry - I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
    5. ↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
    6. 1 2 Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 471. ISBN 9781284057560.
    7. ↑ Flanagan, Robert; Jones, Alison; Maynard, Robert L. (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
    8. ↑ Kasture, A.V., Dr. (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
    9. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
    Identifiers:
    • "Sodium calcium edetate". U.S. National Library of Medicine. Drug Information Portal. U.S. National Institutes of Health. Archived from the original on 29 August 2021. Retrieved 17 May 2020.
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